Aim. To study the features of disease progress and approaches to the diagnostics of acute myocardial infarction (MI) among elderly and senile patients and their influence on the management in the acute period of disease.Materials and methods. The study was performed using the WHO program “Register of acute myocardial infarction” (Tomsk). The study included 410 patients (60 years and older), who had acute MI. The study group is represented by a comparable number of men (n=212) and women (n=198). The mean age of patients was 71 (66; 77) years (women are 5 years older than men (p<0,001)). Statistical processing was performed using the program Statistica V10.0.Results. Most of the patients had history comorbid pathology. In one in five patients (17,8%), the disease had an atypical manifestations, which in 41% of cases was represented by the asymptomatic form. Atypical manifestation of MI lengthened the prehospital phase of medical care due to a longer time before the first medical contact (p=0,005), as well as a late help-seeking (120 [49; 311,5] minutes). In 28% of patients, the level of creatine kinase-MB remained normal, and the indicator of troponin I exceeded the maximum values only in half of the cases. One fifth of the patients underwent acute MI treatment in non-core hospitals, which resulted in a low frequency of intervention (38%) and increasing by 2 times the chance of death within 5 years. The level of hospital mortality from acute MI in elderly patients in noncore hospitals was 3 times higher than in specialized departments (p<0,001).Conclusion. Difficulties in diagnostics of MI in patients of older age groups is caused by the prevalence of comorbid pathology, an atypical manifestations of the disease and low information content of biochemical markers of myocardial necrosis. It leads to an increase in time delays at the prehospital phase and frequent hospitalization of patients in non-core hospitals, making it impossible for them to receive timely, preferred therapy.

Основные положения• Приверженность лечению является отдельным независимым аспектом эффективности мероприятий вторичной профилактики ИБС. Несоблюдение врачебных рекомендаций пациентами, перенесшими ИМ, приводит к кратному увеличению вероятности развития неблагоприятных сердечно-сосудистых событий в постинфарктном периоде. При этом менее половины пациентов, выживших после перенесенного инфаркта миокарда, строго соблюдают рекомендации лечащего врача относительно применяемой медикаментозной терапии.

Cardiotoxicity of anthracycline chemotherapy drugs is one of the main interdisciplinary problems in the research area of cardio-oncology. As is known, the high antitumor effi cacy of anthracycline antibiotics is signifi cantly leveled by the development of disabling and lethal heart lesions. However, the pathogenesis of toxic heart disease, as well as diagnostic criteria and markers of anthracycline-induced cardiomyopathy are not fully understood. The article provides a detailed review of potential markers of anthracycline cardiotoxicity from the position of disease pathogenesis. The scheme of pathogenetic development of anthracycline-induced cardiomyopathy is proposed in this article. The main methods of diagnostics of toxic damage of the heart that are currently used in clinical researches of domestic and foreign scientists are reviewed.

Aim. To study how to change the portrait of the patient with acute myocardial infarction (AMI) for a 30-year period in the global aging of the population, and conduct a comparative assessment of the main epidemiological indicators of AMI over the period of time. Material and methods. The study included patients with AMI registered in the database «Register of acute myocardial infarction» in 1986 (593 cases) and 2015 (729 cases), respectively. Statistical processing of the results was performed using the statistical program Statistica V10.0. Results. Over a 30-year period, the proportion of elderly patients increased by 13.4% (p<0.001). Among men younger than 60 years decreased morbidity, mortality, and hospital mortality from AMI. In persons 60 years and older reduced the incidence of first AMI, however, the incidence of re-AMI and morbidity and mortality has not decreased. Often the AMI was to develop on the background of comorbidities (p<0.001). A marked increase in the number of atypical forms of the disease from 11.6% in 1986 to 33.2% in 2015 (p<0.001), mostly among patients of older age groups. Elderly patients are often hospitalized in non-core hospitals (7.7% in 1986 compared to 13.6% - in 2015; p<0.001). There was an increased incidence of acute left ventricular failure, cardiogenic shock, arrhythmias (p<0.001). Conclusions. Thus, the significant increase ofpatients' age at the time of development of AMI in 2015, compared with 1986, is a reflection of the process of demographic aging of the population, and inevitably leads to the accumulation of comorbid pathology, weighting demographic status of patients, the clinical picture of the disease and causes to significant difficulty in providing effective specialized medical care to patients.