The Role of Vitamin C in Prevention of Preterm Premature Rupture of Membranes

Abstract

BackgroundPreterm premature rupture of membranes (PPROM) is one of the most important complications of the pregnancy and cause perinatal morbidity and mortality. History of PPROM is a risk factor of recurrent PPROM. Vitamin C plays an important role in collagen metabolism and increases resistance maintenance of the chorioamniotic membranes.ObjectivesThe aim of this study is to evaluate the role of vitamin C supplementation in prevention of PPROM in women with a positive history of PPROM.Patients and MethodsThis clinical trial study was performed on 170 pregnant women with the history of PPROM, with singleton pregnancy and gestational age 14 weeks in Imam-Reza Hospital, Mashhad University of Medical Sciences during 2008 to 2010. They were randomly divided into two groups. The case patients received 100 mg vitamin C daily from 14th weeks of gestation. PPROM occurrence was compared between two groups as an indicator of the protective effect of vitamin C supplements.ResultsPPROM occurred in 44.7% of controls and 31.8% of cases (P < 0.05). PROM occurred in 34.1% of controls and 18.8% of cases (P < 0.05). Pregnancy was terminated at term gestation in 21.2% of controls and 49.4% of cases (P < 0.05). Rupture of membranes was significantly decreased in the case group.ConclusionsVitamin C supplementations after 14th weeks of gestation can prevent from PPROM in women with the history of PPROM.

The low level of plasma vitamin C as a risk factor of preterm premature rupture of membrane

“…However the results have been varied. [18][19][20] Therefore, a threshold value is needed to differentiate pregnant women with or without low plasma vitamin C level and to prove whether there is a relationship between low plasma vitamin C level and an increased risk of premature rupture of membranes in preterm pregnancy. This study shows that a plasma vitamin C level of 6.45 mg/L can be used as a threshold value to determine the status of a high plasma vitamin C level in preterm pregnancy.…”

Hubungan Asupan Dan Kadar Vitamin C Dengan Kadar Matriks Metaloproteinase-1 Pada Ketuban Pecah Dini

“…There is no significant relationship between vitamin C and MMP-1 serum levels in PROM (p=0,666) and normal pregnancy (p=0,201 (Pearlman,et al, 2004). KPD merupakan salah satu masalah obstetri yang sering terjadi dengan angka kejadian di dunia lebih kurang 10 % dari semua kehamilan (Ghomian, et al, 2013). Di Indonesia, kejadian KPD berkisar antara 6-10% dari semua kelahiran (Kemenkes RI, 2015).…”

“…Vitamin C juga berperan sebagai agen pereduksi radikal bebas (Bowman, et al, 2001). Ghomian, et al (2013) menyatakan bahwa KPD menurun secara signifikan pada kelompok yang di suplementasi vitamin C dibandingkan kelompok control (Ghomian, et al, 2013). Penelitian oleh Rizka, dkk (2011) menemukan tidak ada perbedaan bermakna antara kadar vitamin C serum ibu hamil dengan KPD dibandingkan dengan ibu hamil normal (Rizka, dkk, 2011).…”

Is vitamin C able to prevent premature rupture of membranes?

“…27 Ghomian et al showed similar result that PPROM and PROM were significantly decreased significantly in the group that received 100 mg vitamin C from 14 weeks of gestational age compred to control (31.8% vs 44.7%; p<0.05 and 18.8% vs 34.4%; p<0.05). 28 Casanueva et al (2005) showed that 100 mg of Vitamin C per day was sufficient to maintain leukocyte ascorbic acid concentration at a level above 18 mg/10 8 cells, level to protect aginst PROM. 24 In addition, Simhan et al (2005) reported vitamin C usage significantly increased the gestational age at delivery, neonatal Apgar score, birth-weight, and latency period.…”