The role of α-tocopherol in preventing disease: from epidemiology to molecular events

Azzi, Angelo; Gysin, René; Kempná, Petra; Ricciarelli, Roberta; Villacorta, Luis; Visarius, Theresa; Zingg, Jean‐Marc

doi:10.1016/s0098-2997(03)00028-1

Cited by 95 publications

(57 citation statements)

References 86 publications

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“…In addition, the antioxidants may also be capable of triggering the cell survival signals, thereby protecting the cells from apoptosis due to their non-antioxidant capacity. 22) In conclusion, the present study clearly shows that, under low oxygen concentrations, free radicals further augmented the cell death by inducing free radical chain reactions and consequent oxygen deprivation. The cell death followed the intrinsic, mitochondrial apoptosis pathway and could be rescued by both caspase inhibitor and antioxidants.…”

Section: Discussionsupporting

confidence: 57%

Effect of Oxygen Concentration on Free Radical-Induced Cytotoxicity

Chen

Saito

Yoshida

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionsupporting

confidence: 57%

Effect of Oxygen Concentration on Free Radical-Induced Cytotoxicity

Chen

Saito

Yoshida

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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Section: Maternal Antioxidant Intake During Pregnancy and Childhood Amentioning

confidence: 99%

“…The absence of a general association with antioxidants such as vitamin C and carotenoids and the associations with immune and lung function suggest that biological properties of vitamin E independent of antioxidant activity may be relevant (102) . Vitamin E and flavonoids have been reported to have complex effects on immunological and inflammatory pathways that may be relevant to the development of asthma and allergic disease (102)(103)(104) . The anti-inflammatory effects of vitamin E are believed to be mediated by the inhibition of protein kinase B and C activity, which may inhibit the activation and DNA binding of the transcription factor NF-kB, with consequent effects on the regulation of inflammatory cytokines, adhesion molecules and other proinflammatory molecules.…”

Section: Maternal Antioxidant Intake During Pregnancy and Childhood Amentioning

confidence: 99%

Session 1: Allergic disease Nutrition as a potential determinant of asthma

Devereux

2009

Proc. Nutr. Soc.

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Asthma is characterised by chronic lung airway inflammation, increased airway responsiveness and variable airflow obstruction. In Westernised countries asthma is a public health concern because of its prevalence, associated ill health and high societal and healthcare costs. In recent decades there has been a marked increase in asthma prevalence, particularly in Westernised countries. It has been proposed that changing diet has contributed to the increase in asthma. Several dietary hypotheses exist; the first relates the increase in asthma to declining dietary antioxidant intake, the second to decreased intake of long-chainn-3 PUFA and increasing intake ofn-6 PUFA. Vitamin D supplementation and deficiency have also been hypothesised to have contributed to the increase in asthma. Observational studies have reported associations between asthma and dietary antioxidants (vitamin E, vitamin C, carotenoids, Se, flavonoids, fruit), lipids (PUFA, butter, margarine, fish) and vitamin D. However, supplementing the diets of adults with asthma with antioxidants and lipids has minimal, if any, clinical benefit. There is growing interest in the possibility that childhood asthma is influenced by maternal diet during pregnancy, with studies highlighting associations between childhood asthma and maternal intake of some nutrients (vitamin E, vitamin D, Se, PUFA) during pregnancy. It has been suggested that maternal diet during pregnancy influences fetal airway and/or immune development. Further intervention studies are needed to establish whether modification of maternal nutrient intake during pregnancy can be used as a healthy low-cost public health measure to reduce the prevalence of childhood asthma.

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“…In cases of osteoarthritis, synovial and subchondral vascular engorgement results in necrosis and the gradual remodeling of tissue (46). Vitamin E, along with a network of cellular antioxidant mediators, including catalases and superoxide dismutase, plays a role in the elimination of lipid-soluble free radicals through its action as a free radical scavenger (9). Furthermore, vitamin E is involved in the regulation of certain cellular events, such as the cell cycle progression of vascular smooth muscle cells, the expression of adhesion molecules, the deposition of extracellular matrix and aggregation of platelets (47).…”

Section: Vitamin E Protects the Subchondral Vascular System Which Maymentioning

confidence: 99%

“…Vitamin E has various biological functions that have been attributed to its ability to protect an organism against the damaging effects of free radicals by acting as a lipid-based radical chain reaction terminator (9). Vitamin E is a fat-soluble, water-insoluble, light yellow oil, that is stable to heat and acids, but rather unstable under alkali conditions, in which it is slowly oxidized.…”

Section: Introductionmentioning

confidence: 99%

Vitamin E slows down the progression of osteoarthritis

Zhang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Osteoarthritis is a chronic degenerative joint disorder with the characteristics of articular cartilage destruction, subchondral bone alterations and synovitis. Clinical signs and symptoms of osteoarthritis include pain, stiffness, restricted motion and crepitus. It is the major cause of joint dysfunction in developed nations and has enormous social and economic consequences. Current treatments focus on symptomatic relief, however, they lack efficacy in controlling the progression of this disease, which is a leading cause of disability. Vitamin E is safe to use and may delay the progression of osteoarthritis by acting on several aspects of the disease. In this review, how vitamin E may promote the maintenance of skeletal muscle and the regulation of nucleic acid metabolism to delay osteoarthritis progression is explored. In addition, how vitamin E may maintain the function of sex organs and the stability of mast cells, thus conferring a greater resistance to the underlying disease process is also discussed. Finally, the protective effect of vitamin E on the subchondral vascular system, which decreases the reactive remodeling in osteoarthritis, is reviewed.

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The role of α-tocopherol in preventing disease: from epidemiology to molecular events

Cited by 95 publications

References 86 publications

Effect of Oxygen Concentration on Free Radical-Induced Cytotoxicity

Effect of Oxygen Concentration on Free Radical-Induced Cytotoxicity

Session 1: Allergic disease Nutrition as a potential determinant of asthma

Vitamin E slows down the progression of osteoarthritis

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