The roles of drug therapy given via the endotracheal tube to neonates

Greenough, Anne; Papalexopoulou, Niovi

doi:10.1136/archdischild-2016-311711

Cited by 1 publication

(1 citation statement)

References 53 publications

(60 reference statements)

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“…Overall, newborns are more prone to develop adverse events, which could be reduced by avoiding systemic drug exposure (2). Therefore, local pulmonary delivery of novel drug candidates could be safer and reduce off-target organ exposure (14). In this regard, a recent and successful approach has been reported by Yeh et al consisting of the combined intratracheal administration of a surfactant-budesonide mixture (46).…”

Section: Introductionmentioning

confidence: 99%

Local pulmonary drug delivery in the preterm rabbit: feasibility and efficacy of daily intratracheal injections

Salaets

Gie

Jiménez

et al. 2019

American Journal of Physiology-Lung Cellular and Molecular Phys

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Recent clinical trials in newborns have successfully used surfactant as a drug carrier for an active compound, to minimize systemic exposure. To investigate the translational potential of surfactant-compound mixtures and other local therapeutics, a relevant animal model is required in which intratracheal administration for maximal local deposition is technically possible and well tolerated. Preterm rabbit pups (born at 28 days of gestation) were exposed to either hyperoxia or normoxia and randomized to receive daily intratracheal surfactant, daily intratracheal saline, or no injections for 7 days. At day 7, the overall lung function and morphology were assessed. Efficacy in terms of distribution was assessed by micro-PET-CT on both day 0 and day 7. Lung function as well as parenchymal and vascular structure were altered by hyperoxia, thereby reproducing a phenotype reminiscent of bronchopulmonary dysplasia (BPD). Neither intratracheal surfactant nor saline affected the survival or the hyperoxia-induced BPD phenotype of the pups. Using PET-CT, we demonstrate that 82.5% of the injected radioactive tracer goes and remains in the lungs, with a decrease of only 4% after 150 min. Surfactant and saline can safely and effectively be administered in spontaneously breathing preterm rabbits. The described model and method enable researchers to evaluate intratracheal pharmacological interventions for the treatment of BPD.

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Section: Introductionmentioning

confidence: 99%