The roles of the Drosophila JAK/STAT pathway

Zeidler, Martin P.; Bach, Erika A.; Perrimon, Norbert

doi:10.1038/sj.onc.1203482

Cited by 147 publications

(100 citation statements)

References 36 publications

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“…The JAK-STAT pathway operates in Drosophila as well as in mammals (12). STAT92E (13,14) is activated by hopscotch (HOP), the single Drosophila tyrosine kinase of the JAK family (15), after cells encounter outstretched (OS), a membraneassociated ligand, whose receptor is not yet identified (16).…”

Section: A Drosophila Pias Homologue Negatively Regulates Stat92ementioning

confidence: 99%

A Drosophila PIAS homologue negatively regulates stat92E

Betz

Lampen

Martinek

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

120

110

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Transcriptional activation by, and therefore the physiologic impact of, activated tyrosine-phosphorylated STATs ( s ignal t ransducers and a ctivators of t ranscription) may be negatively regulated by proteins termed PIAS ( p rotein i nhibitors of a ctivated s tats), as shown by previous experiments with mammalian cells in culture. Here, by using the genetic modifications in Drosophila , we demonstrate the in vivo functional interaction of the Drosophila homologues stat92E and a Drosophila PIAS gene ( dpias ). To this end we use a LOF allele and conditionally overexpressed dpias in JAK-STAT pathway mutant backgrounds. We conclude that the correct dpias / stat92E ratio is crucial for blood cell and eye development.

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Section: A Drosophila Pias Homologue Negatively Regulates Stat92ementioning

confidence: 99%

A Drosophila PIAS homologue negatively regulates stat92E

Betz

Lampen

Martinek

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

120

110

View full text Add to dashboard Cite

show abstract

“…The differentiation How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions Phoebe Tzou, Ennio De Gregorio and Bruno Lemaitre* and proliferation of larval haemocytes occur either in the lymph gland or in circulation. These processes are under the control of two conserved signalling pathways: the janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, which is important for lamellocyte differentiation [12]; and the Toll pathway, which is required for proper haemocyte proliferation [13].…”

Section: Haemocyte Differentiation and Functionmentioning

confidence: 99%

How Drosophila combats microbial infection: a model to study innate immunity and host–pathogen interactions

Tzou

Gregorio

Lemaître

2002

Current Opinion in Microbiology

325

228

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“…The establishment of planar polarity and the precise determination of the equator is orchestrated by complex signaling involving counteracting gradients of Wg (Wehrli and Tomlinson, 1998), Jak/Stat (Zeidler et al, 1999b(Zeidler et al, , 2000a and Notch signaling activities (Blair, 1999;Cho and Choi, 1998;Dominguez and de Celis, 1998;Papayannopoulos et al, 1998). These combined signals ensure correct patterning across distances of several hundreds of cells in the eye ®eld (Bray, 2000;Mlodzik, 1999;Strutt and Strutt, 1999).…”

Section: Planar Polaritymentioning

confidence: 99%