The roles of tissue-resident macrophages in sepsis-associated organ dysfunction

Gao, Yulei; Tian, Xin; Zhang, Xiang; Milebe Nkoua, Grace Divine; Chen, Fang; Liu, Yancun; Chai, Yanfen

doi:10.1016/j.heliyon.2023.e21391

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e21391

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The roles of tissue-resident macrophages in sepsis-associated organ dysfunction

Yulei Gao,

Xin Tian,

Xiang Zhang

et al.

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2024

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Cited by 3 publications

References 158 publications

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Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

Kondo,

Okada,

Shizuya

et al. 2024

European Journal of Cell Biology

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Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

Kondo,

Okada,

Shizuya

et al. 2024

European Journal of Cell Biology

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Delayed macrophage targeting by clodronate liposomes worsens the progression of cytokine storm syndrome

Khanna,

Eul,

Yan

et al. 2024

Front. Immunol.

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Excessive macrophage activation and production of pro-inflammatory cytokines are hallmarks of the Cytokine Storm Syndrome (CSS), a lethal condition triggered by sepsis, autoimmune disorders, and cancer immunotherapies. While depletion of macrophages at disease onset protects from lethality in an infection-induced CSS murine model, patients are rarely diagnosed early, hence the need to characterize macrophage populations during CSS progression and assess the therapeutic implications of macrophage targeting after disease onset. In this study, we identified MHCII+F4/80+Tim4- macrophages as the primary contributors to the pro-inflammatory environment in CSS, while CD206+F4/80+Tim4+ macrophages, with an anti-inflammatory profile, become outnumbered. Additionally, we observed an expansion of Tim4- macrophages coinciding with increased hematopoietic stem progenitor cells and reduction of committed myeloid progenitors in bone marrow and spleen. Critically, macrophage targeting with clodronate liposomes at disease onset prolonged survival, while their targeting in mice with established CSS exacerbated disease severity, leading to a more dramatic loss of Tim4+ macrophages and an imbalance in pro- versus anti-inflammatory Tim4− macrophage ratio. Our findings highlight the significance of timing in macrophage-targeted interventions for effective management of CSS and suggest potential therapeutic strategies for diseases characterized by uncontrolled inflammation, such as sepsis.

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Early Fever in Allogeneic Stem Cell Transplantation: Are Presepsin and YKL-40 Valuable Diagnostic Tools?

Babel,

Košuta,

Vujaklija Brajković

et al. 2024

JCM

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Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a lifesaving treatment but carries a high infection risk. Diagnosing infections remains challenging due to the limited accuracy of standard biomarkers. Methods: This single-center study aimed to evaluate presepsin (PSP) and YKL-40 as infection biomarkers in febrile patients during the allo-HSCT pre-engraftment phase. Biomarker levels were prospectively measured in 61 febrile episodes from 54 allo-HSCT patients at admission, representing baseline levels, and then at Day 1, 3, 5, and 7 following fever onset. The diagnostic value was compared to that of procalcitonin (PCT). Results: PSP showed fair diagnostic value on Day 1 (AUC 0.656; 95% CI: 0.510–0.802) and Day 3 (AUC 0.698; 95% CI: 0.559–0.837). YKL-40 did not provide any significant diagnostic value across measured time points. PCT outperformed PSP and YKL-40, particularly on Day 3 (AUC 0.712; 95% CI: 0.572–0.852). When combining biomarkers, the best model for predicting infection used PSP > 3.144 ng/mL and PCT > 0.28 μg/L on Day 3, resulting in R2 of about 31% (p < 0.001). Conclusions: Neither test showed sufficient discriminative power for early infection to recommend their use as individual diagnostic tools in clinical practice.

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The roles of tissue-resident macrophages in sepsis-associated organ dysfunction

Cited by 3 publications

References 158 publications

Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders

Delayed macrophage targeting by clodronate liposomes worsens the progression of cytokine storm syndrome

Early Fever in Allogeneic Stem Cell Transplantation: Are Presepsin and YKL-40 Valuable Diagnostic Tools?

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