a b s t r a c tWe propose a research program to analyse spatial aspects of the science system. First, we provide a review of scientometric studies that already explicitly take the spatial dimension into account. The review includes studies on (i) the spatial distribution of research and citations, (ii) the existence of spatial biases in collaboration, citations and mobility, and (iii) the citation impact of national versus international collaborations. Then, we address a number of methodological issues in dealing with space in scientometrics. Finally, to integrate spatial and non-spatial approaches, we propose an analytical framework based on the concept of proximity. A proximity approach allows for combining hypotheses from different theoretical perspectives into a single framework.