The selective agonist of dopamine D2 receptors cabergoline decreases alcohol consumption and increases the level of DRD2 mRNA in the brain of rats with chronic alcohol intoxication

Анохин, П. К.; Shamakina, I. Yu.; Proskuryakova, T.V.; Shokhonova, V.A.; Ulyanova, E.V.; Tarabarko, I.E.; Anokhina, I. P.

doi:10.1134/s1819712417010020

Cited by 3 publications

(3 citation statements)

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“…Nevertheless, we did not observe an effect on alcohol consumption, when hordenine was given during reinstatement. The selective D 2 R agonism may have caused this decrease in alcohol consumption, to some extent by dysregulation of D 2 R expression 50,51 . The CPP paradigm is widely used to examine the reinforcing effects of drugs or natural stimuli 40 .…”

Section: Discussionmentioning

confidence: 99%

“…The selective D 2 R agonism may have caused this decrease in alcohol consumption, to some extent by dysregulation of D 2 R expression. 50,51 The CPP paradigm is widely used to examine the reinforcing effects of drugs or natural stimuli. 40 In this study, repeated alcohol exposure led to the establishment of an alcohol CPP.…”

Section: Effects Of Hordenine On Gpcrs Human Sert and Dat And Gaba Re...mentioning

confidence: 99%

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The beer component hordenine inhibits alcohol addiction‐associated behaviours in mice

Vogel

Kalinichenko

et al. 2023

Addiction Biology

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Alcohol consumption is a widespread behaviour that may eventually result in the development of alcohol use disorder (AUD). Alcohol, however, is rarely consumed in pure form but in fruit-or corn-derived preparations, like beer. These preparations add other compounds to the consumption, which may critically modify alcohol intake and AUD risk. We investigated the effects of hordenine, a barley-derived beer compound on alcohol use-related behaviours. We found that the dopamine D2 receptor agonist hordenine (50 mg/kg) limited ongoing alcohol consumption and prophylactically diminished relapse drinking after withdrawal in mice. Although not having reinforcing effects on its own, hordenine blocked the establishment of alcohol-induced conditioned place preference (CPP). However, it independently enhanced alcohol CPP retrieval. Hordenine had a dose-dependent inhibitory effect on locomotor activity. Chronic hordenine exposure enhanced monoamine tissue levels in many brain regions. Further characterization revealed monoaminergic binding sites of hordenine and found a strong binding on the serotonin and dopamine transporters, and dopamine D 3 , and adrenergic α 1A and α 2A receptor activation but no effects on GABA A receptor or glycinergic signalling. These findings suggest that natural ingredients of beer, like hordenine, may work as an inhibitory and use-regulating factor by their modulation of monoaminergic signalling in the brain.

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Section: Discussionmentioning

confidence: 99%

Section: Effects Of Hordenine On Gpcrs Human Sert and Dat And Gaba Re...mentioning

confidence: 99%

The beer component hordenine inhibits alcohol addiction‐associated behaviours in mice

Vogel

Kalinichenko

et al. 2023

Addiction Biology

View full text Add to dashboard Cite

show abstract

“…Nevertheless, we did not observe an effect on alcohol consumption when hordenine was given during reinstatement. The selective dopamine D2 receptor agonism may have caused this decrease in alcohol consumption, to some extent by dysregulation of dopamine D2 receptor expression [218,219].…”

Section: No Effects Of Hordenine During Reinstatement Of Alcohol Drin...mentioning

confidence: 99%