The Self‐Assembly of Anticancer Camptothecin–Dipeptide Nanotubes: A Minimalistic and High Drug Loading Approach to Increased Efficacy

Kim, Se Hye; Kaplan, Jonah A.; Sun, Yuan; Shieh, Aileen; Sun, Hui-Lung; Croce, Carlo M.; Grinstaff, Mark W.; Parquette, Jon R.

doi:10.1002/chem.201404520

Cited by 86 publications

(52 citation statements)

References 66 publications

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“…Biomaterial delivery systems such as nanotubes, [26][27] nanoparticles, [28][29] micelles, 30 and drug eluting devices 31 are being developed to reduce the dose required with the aim of reducing side effects and thus improving effectiveness. Herein, our approach has been to develop a material that delivers a defined quantity of drug along with oxygen or peroxide in an attempt to improve the efficiency of chemotherapeutic drug action.…”

Section: Figure 2 Tunable Release Of Either Oxygen or Doxorubicin Camentioning

confidence: 99%

Oxygen-Producing Gellan Gum Hydrogels for Dual Delivery of Either Oxygen or Peroxide with Doxorubicin

Newland

Baeger

Eigel

et al. 2017

ACS Biomater. Sci. Eng.

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Hypoxic environments in the core of tumors can give rise to resistance against anticancer therapeutics. Oxygen-producing biomaterials may be able to improve chemotherapeutic efficiency by locally disrupting the hypoxic environment. We hypothesized that gellan gum hydrogels could be loaded with both a solid peroxide and the chemotherapeutic drug doxorubicin, to release both oxygen and doxorubicin simultaneously. We show that calcium peroxide physically cross-links gellan gum into a hydrogel, which when loaded with catalase raises the dissolved oxygen content of media for up to 64 h. Additionally, doxorubicin could be loaded into the hydrogel in situ, allowing release in well-defined quantities.

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Section: Figure 2 Tunable Release Of Either Oxygen or Doxorubicin Camentioning

confidence: 99%

Oxygen-Producing Gellan Gum Hydrogels for Dual Delivery of Either Oxygen or Peroxide with Doxorubicin

Newland

Baeger

Eigel

et al. 2017

ACS Biomater. Sci. Eng.

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“…A collaboration between the labs of Grinstaff and Parquette, for instance, led to the creation of a simple conjugate in which CPT was attached to the ε-amine of the C -terminal lysine in a Lys-Lys dipeptide (47% drug loading) (Fig. 7A) [117]. Dissolution of the solid form in PBS and subsequent aging led to the formation of large nanotubule structures with diameters ranging from 80 to 120 nm and lengths of several micrometers.…”

Section: Supramolecular Nanostructures Formed By Amphiphilic Prodrugsmentioning

confidence: 99%

“…While the CAC of the assembly is typically seen as the defining property, it is perhaps the resistance to disassembly upon dilution that is of greater import. Asymmetry in these two phenomena is quite possible for instance [117], as though a relatively high concentration may be required for assembly to occur, the strong intermolecular interactions that may form during this process could result in a much lower disassembly concentration. How this will play into in vivo efficacy remains to be determined, however, and may be challenging to ascertain.…”

Section: Supramolecular Nanostructures Formed By Amphiphilic Prodrugsmentioning

confidence: 99%

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Building nanostructures with drugs

2016

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The convergence of nanoscience and drug delivery has prompted the formation of the field of nanomedicine, one that exploits the novel physicochemical and biological properties of nanostructures for improved medical treatments and reduced side effects. Until recently, this nanostructure-mediated strategy considered the drug to be solely a biologically active compound to be delivered, and its potential as a molecular building unit remained largely unexplored. A growing trend within nanomedicine has been the use of drug molecules to build well-defined nanostructures of various sizes and shapes. This strategy allows for the creation of self-delivering supramolecular nanomedicines containing a high and fixed drug content. Through rational design of the number and type of the drug incorporated, the resulting nanostructures can be tailored to assume various morphologies (e.g. nanospheres, rods, nanofibers, or nanotubes) for a particular mode of administration such as systemic, topical, and local delivery. This review covers the recent advances in this rapidly developing field, with the aim of providing an in-depth evaluation of the exciting opportunities that this new field could create to improve the current clinical practice of nanomedicine.

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“…Since only amino acids are used to constitute the assembly materials, these nanoparticles are ideal candidates for targeted drug delivery in terms of biocompatibility and systemic toxicity. Kim etc discovered the self-assembly of 20-(S)-Camptothecin-conjugated dipeptides into nanotubes with diameters ranging from 80-120 nm (40). These nanoassemblies maintain a high (~47%) drug loading and exhibit greater drug stability (i.e., resistance to lactone hydrolysis), and consequently greater efficacy against several human cancer cells (HT-29, A549, H460, and H23) in vitro compared with the clinically used prodrug Irinotecan.…”

Section: Introductionmentioning

confidence: 99%

Nanosized Camptothecin Conjugates for Single and Combined Drug Delivery

Chen¹,

Sun²,

Wang³

et al. 2016

Eur J Bio Med Res

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Camptothecin (CPT), a natural DNA topoisomerase 1 inhibitor, is commonly used as a model hydrophobic compound for anticancer drug delivery research. Nanoparticle loaded with active drugs has the potential to selectively deliver the therapeutic agents into tumor cells without affecting the normal tissues, and hence is attracting tremendous attention from biomedical scientists. Nanoparticles can benefit from the enhanced permeability and retention effect (EPR) of the tumor tissues that allows nanoparticles to be transported through the leaky blood vessels and retained for a longer time compared with traditional small molecule drugs. In particular, covalent camptothecin conjugates are of extensive interest due to their robust stability by covalent chemical bonding. In this mini-review, recent progress of nanosized camptothecin conjugates will be discussed with the focus on the difference of delivery materials as well as their potential of combined drug delivery for the therapy of cancer.

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The Self‐Assembly of Anticancer Camptothecin–Dipeptide Nanotubes: A Minimalistic and High Drug Loading Approach to Increased Efficacy

Cited by 86 publications

References 66 publications

Oxygen-Producing Gellan Gum Hydrogels for Dual Delivery of Either Oxygen or Peroxide with Doxorubicin

Oxygen-Producing Gellan Gum Hydrogels for Dual Delivery of Either Oxygen or Peroxide with Doxorubicin

Building nanostructures with drugs

Nanosized Camptothecin Conjugates for Single and Combined Drug Delivery

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