The sentinel node procedure in early stage cervical cancer, taking the next step; a diagnostic review

Tax, Casper; Rovers, Maroeska M.; Graaf, Corine de; Zusterzeel, Petra L.M.; Bekkers, Ruud L.M.

doi:10.1016/j.ygyno.2015.09.076

Cited by 120 publications

(119 citation statements)

References 62 publications

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“…The AGO sentinel lymph node study confirmed the results of a meta-analysis in early-stage cancer: if the cervical tumor size is < 2 cm, the negative predictive value is 99% and the specificity 97% [44,45,46]. In a recent review, Tax et al [47] showed that in early-stage cervical cancer patients (defined as FIGO stages IA2, IB1, or IIA1 with tumor sizes of < 4 cm) with no suspicion upon preoperative imaging or on intraoperative inspection, and - more importantly - who have negative bilateral sentinel lymph nodes after ultra-staging has been performed, will only exhibit a 0.08% risk for undetected metastases (i.e. false-negative rate of 0.08%).…”

Section: Lymphadenectomy: Abandonment Sentinel or Systematic?mentioning

confidence: 77%

Surgical Treatment of Early-Stage Cervical Cancer

Brucker

Ulrich

2016

Oncol Res Treat

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Surgical treatment of cervical cancer has been a cornerstone in the management of this malignancy for more than 100 years. Today, for early-stage and low-risk cervical cancer, surgery is still considered the gold standard. If the preoperative assessment of the tumor reveals a situation prompting postoperative adjuvant radiochemotherapy, the latter should be planned as the primary treatment option, being preceded by staging laparoscopy including pelvic and paraaortic lymph node dissection. As an alternative to the open approach, the definitive surgical treatment should be either performed laparoscopically, or be laparoscopic-assisted, or laparoscopically robotic-assisted.

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Section: Lymphadenectomy: Abandonment Sentinel or Systematic?mentioning

confidence: 77%

Surgical Treatment of Early-Stage Cervical Cancer

Brucker

Ulrich

2016

Oncol Res Treat

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“…34 Other studies have shown similar results. [35][36][37] However, the following criteria must be met: the technique is indicated for tumors in stages IA2, IB1 and IIA1 (tumor up to 4 cm), except for cases in which there is reduced sensibility using the method, such as in tumors sized more than 2 cm; absence of lymph node involvement (on imaging and intraoperative); bilateral identification of the sentinel lymph node (at least one node in each hemi-pelvis). The accuracy of the method is improved by lymph nodal "ultra-staging" (serial sections of the sentinel lymph node).…”

Section: Fertility Preservationmentioning

confidence: 99%

“…The accuracy of the method is improved by lymph nodal "ultra-staging" (serial sections of the sentinel lymph node). 36,37 Nevertheless, it cannot be performed during surgery, and, if the nodes are positive, a second operation is needed. The SENTICOL II trial is cur-tion included in the study, 75% had received prior treatment with cisplatin for recurrent disease.…”

Section: Fertility Preservationmentioning

confidence: 99%

Cervical cancer: what's new?

Sadalla

Andrade

Genta³

et al. 2015

Rev. Assoc. Med. Bras.

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Financial support: none Cervical cancer is the most common gynecological cancer in Brazil. Among women, it is the second most frequent, second only to breast cancer. It is the fourth leading cause of cancer death in the country, with estimated 15,590 new cases (2014) and 5,430 deaths (2013). In order to update information to improve outcomes, reduce morbidity and optimize the treatment of this cancer, this article will address the advancement of knowledge on cervical cancer. The topics covered include the role of surgery in different stages, treatment of locally advanced carcinomas, fertility preservation, the role of the sentinel lymph node technique, indications and techniques of radiotherapy and chemotherapy, and some special situations.

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“…The use of such radiopharmaceuticals as Nanocoll, 99m Tc-nanocolloid, Nanocis, Microlite and Sulfurcolloid for SLN detection have several drawbacks [8,9]. Their applications are limited by their complex manufacturing process and high cost.…”

Section: Introductionmentioning

confidence: 99%

The first experience of using 99mTc-Al2O3-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients

Синилкин¹,

Chernov²,

Lyapunov

et al. 2016

AIP Conference Proceedings

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Abstract. The purpose of the study was to evaluate the feasibility of using 99m Tc-Al 2 O 3 -based radiopharmaceutical, a novel molecular imaging agent for sentinel lymph node detection in patients with invasive cervical cancer. The study included 23 cervical cancer patients (T1aN M -T2bN M ) treated at the Tomsk Cancer Research Institute. In the 18 hours before surgery, 80 MBq of the 99m Tc-Al 2 O 3 in peritumoral injected, followed by single-photon emission computed tomography (SPECT) of the pelvis and intraoperative SLN identification. Twenty-seven SLNs were detected by SPECT, and 34 SLNs were identified by intraoperative gamma probe. The total number of identified SLNs per patient ranged from 1 to 3 (the mean number of SLNs was 1.4 per patient). The most common site for SLN detection was the external iliac region (57.2%), followed by the internal iliac (14%), obturator (14%), presacral and retrosacral regions (14%), and the parametrial region (1%). Sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 79% for SPECT image.

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The sentinel node procedure in early stage cervical cancer, taking the next step; a diagnostic review

Cited by 120 publications

References 62 publications

Surgical Treatment of Early-Stage Cervical Cancer

Surgical Treatment of Early-Stage Cervical Cancer

Cervical cancer: what's new?

The first experience of using 99mTc-Al2O3-based radiopharmaceutical for the detection of sentinel lymph nodes in cervical cancer patients

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