The Serum Transport of Steroid Hormones

Pk, Srivastava; Jt, Murai; Hammond, Geoffrey L.; Ja, Nisker; Wj, Raymoure; Rw, Kuhn

doi:10.1016/b978-0-12-571138-8.50016-0

Cited by 430 publications

(353 citation statements)

References 85 publications

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“…Besides cytosol also membrane preparations of the pituitary displayed binding specificity similar to that displayed by the CBG-like binding system [16]. Immunocytochemical observations reported from this laboratory [17] and from elsewhere [18] indicated intracellular localization of the CBG-like binding system in the pituitary. Specificity and sensitivity of the used peroxydas~antiperoxydase (PAP) technique has been improved recently and we now report that localization of CBG-like immunoreactive products is restricted to certain cell types of the anterior pituitary.…”

Section: Introductionsupporting

confidence: 55%

Intracellular CBG-like molecules in the rat pituitary

Kloet

Voorhuis

Leunissen³

et al. 1984

Journal of Steroid Biochemistry

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Summary-The localization of transcortin (CBG) in pituitary cells of the rat was investigated using the peroxydase-antiperoxydase (PAP) technique. A rabbit antiserum against purified rat plasma transcortin was used as the primary antiserum. Transcortin-like (CBG-like) immunoreactive products were found in the cytoplasma of certain cells in the anterior pituitary, but not in the intermediate lobe and weakly in the posterior pituitary. It is postulated that the CBG-like molecules participate in the cellular uptake process of corticosterone, thereby m~uIating the feedback signal of this steroid on pituitary function.

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Section: Introductionsupporting

confidence: 55%

Intracellular CBG-like molecules in the rat pituitary

Kloet

Voorhuis

Leunissen³

et al. 1984

Journal of Steroid Biochemistry

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“…The mean circulating concentration of T in humans ranges from less than 3.5 to 35 nM (Williams and Larsen, 2003). Approximately 2-3% of circulating T is free, non-SHBG bound and is considered bioactive (Siiteri et al, 1982;Pardridge, 1988). Thus, the selected dose of 0.125 nM T is physiologically relevant and enhances the likelihood of antagonist recognition at lower concentrations of the natural ligand since the stronger the effect of the androgen control, the greater the competition (higher concentration) of the antiandrogen required.…”

Section: Cell-based Human Ar-mediated Bioassaymentioning

confidence: 99%

Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products

Chen

Ahn

Gee

et al. 2007

Toxicology and Applied Pharmacology

225

104

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“…Plasma sex hormone-binding globulin (SHBG) binds testosterone and estradiol with high affinity, and selectively transports sex steroid hormones in human plasma (Westphal, 1986, Siiteri et al, 1982, Hammond, 1990. Circulating SHBG is a major determinant of the metabolic clearance of sex steroid hormones, and it modulates their access to target tissues.…”

Section: Introductionmentioning

confidence: 99%

Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome

Pugeat

Nader

Hogeveen

et al. 2010

Molecular and Cellular Endocrinology

108

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. decrease SHBG expression by inducing lipogenesis, which reduces hepatic HNF-4α levels, a transcription factor that play a critical role in controlling the SHBG promoter. Interestingly, diminishing hepatic lipogenesis and free fatty acid liver biosynthesis also appear to be associated with the positive effects of thyroid hormones and PPARγ antagonists on SHBG expression. This mechanism provides a biological explanation for why SHBG is a sensitive biomarker of insulin resistance and the metabolic syndrome, and why low plasma SHBG levels are a risk factor for developing hyperglycemia and type 2 diabetes, especially in women. These important advances in our knowledge of the regulation of SHBG expression in the liver open new approaches for identifying and preventing metabolic disorder associated diseases early in life.

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The Serum Transport of Steroid Hormones

Cited by 430 publications

References 85 publications

Intracellular CBG-like molecules in the rat pituitary

Intracellular CBG-like molecules in the rat pituitary

Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products

Sex hormone-binding globulin gene expression in the liver: Drugs and the metabolic syndrome

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