The severity of muscle ischemia during intermittent claudication

Abstract

Hemoglobin desaturation in exercising calf muscle is profound in patients with claudication, considerably greater even than that induced with three minutes of tourniquet occlusion. Further studies are necessary to investigate the relationship between the inflammatory response and near-infrared spectroscopy during exercise in patients with claudication.

Mitochondrial Bioenergetics in the Metabolic Myopathy Accompanying Peripheral Artery Disease

“…In support of PCr kinetic data, measurement of O 2 kinetics by NIRS suggest increased muscle deoxygenation during exercise and slower reoxygenation post-exercise in PAD (Kooijman et al, 1997; Kemp et al, 2001; Egun et al, 2002; Comerota et al, 2003), where O 2 recovery rate correlate well with PCr recovery rate in PAD patients (Kemp et al, 2001). Collectively, both MRS and NIRS provide robust evidence in vivo of impaired oxidative capacity in skeletal muscle of PAD patients.…”

Muscle Mitochondrial Function in Patients with Type 2 Diabetes Mellitus and Peripheral Arterial Disease: Implications in Vascular Surgery

“…Mitochondrial function expressed as oxidative recovery after exercise is related to the degree of disease of both T2DM and PAD. 12,22,23 The results are therefore presented according to the degree of ischaemic disease (as defined by the TASC II consensus report 36 ) and with and without T2DM.…”

Near-Infrared Spectroscopy with Treadmill Exercise to Assess Lower Limb Ischemia in Patients with Atherosclerotic Occlusive Disease

“…Under these conditions, O 2 delivery is limited, so when exercise continues, tissue Oxy Hb will decrease rapidly, resulting in a corresponding increase in Deoxy Hb. 12,18 As anaerobic metabolites accumulate during exercise, the patient begins to experience pain. When the pain becomes so intense that the patient is forced to stop walking, O 2 consumption declines rapidly and O 2 delivery increases.…”