The significance of the activity of CSF cholinesterases in dementias

Shen, Zheng-Xuan

doi:10.1016/s0306-9877(96)90216-9

Cited by 14 publications

(3 citation statements)

References 89 publications

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“…In the light of a number of reports emphasizing the contribution of cholinergic decline towards memory deficits observed in aging and Alzheimer's disease, our findings may help to explain the neuronal complications taking place under conditions of oxidative stress and aging, as well as in the development of dementia. a non-demented individual may indicate a brain at risk, or that the person is in the preclinical stage of dementia 20 . The erythrocyte membrane is direct target of lipid peroxidation under oxidative stress that involves cleavage of polyunsaturated fatty acids at their double bonds leading to the formation of MDA.…”

Section: Resultsmentioning

confidence: 99%

Age-Dependent Decline in Erythrocyte Acetylcholinesterase Activity: Correlation With Oxidative Stress

Jha¹,

Rizvi²

2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background:Oxidative stress hypothesis offers a mechanism for the aging process and its involvement in other pathologies such as diabetes and neurodegenerative diseases like Alzheimer. AChE activity in erythrocytes may be considered as a marker of central cholinergic status. The present study was undertaken to (i) determine the activity of erythrocyte AChE as a function of human process (ii) correlate AChE activity with oxidative stress during human aging.Material and Methods: Blood was collected from healthy subjects (n = 37) 22-82 years. Erythrocyte AChE activity, MDA and plasma antioxidant capacity in terms of FRAP was measured spectrophotometrically.Results: There was a marked decrease in AChE activity with increasing age. The reduction in activity of AChE correlated well with increased lipid peroxidation and a decrease in FRAP values.Conclusion: Decreased antioxidant defense, and alteration in membrane rheology during aging process both may contribute towards decreased activity of AChE in erythrocyte membrane. This finding may help in explaining the neuronal complications taking place under conditions of oxidative stress, aging, and dementia.

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Section: Resultsmentioning

confidence: 99%

Age-Dependent Decline in Erythrocyte Acetylcholinesterase Activity: Correlation With Oxidative Stress

Jha¹,

Rizvi²

2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Changes in cholinergic function have been characterized, and a strong correlation has been observed with cognitive decline associated with aging. A low activity of AChE or cholinesterase present in cerebrospinal fluid of a non-demented individual may indicate a brain at risk or in the preclinical stage of dementia (Shen 1996). AChE activity is decreased by free radicals and increased oxidative stress (Molochkina et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system

Haider

Saleem

Perveen

et al. 2014

AGE

143

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Oxidative stress from generation of increased reactive oxygen species or free radicals of oxygen has been reported to play an important role in the aging. To investigate the relationship between the oxidative stress and memory decline during aging, we have determined the level of lipid peroxidation, activities of antioxidant enzymes, and activity of acetylcholine esterase (AChE) in brain and plasma as well as biogenic amine levels in brain from Albino-Wistar rats at age of 4 and 24 months. The results showed that the level of lipid peroxidation in the brain and plasma was significantly higher in older than that in the young rats. The activities of antioxidant enzymes displayed an age-dependent decline in both brain and plasma. Glutathione peroxidase and catalase activities were found to be significantly decreased in brain and plasma of aged rats. Superoxide dismutase (SOD) was also significantly decreased in plasma of aged rats; however, a decreased tendency (non-significant) of SOD in brain was also observed. AChE activity in brain and plasma was significantly decreased in aged rats. Learning and memory of rats in the present study was assessed by Morris Water Maze (MWM) and Elevated plus Maze (EPM) test. Short-term memory and long-term memory was impaired significantly in older rats, which was evident by a significant increase in the latency time in MWM and increase in transfer latency in EPM. Moreover, a marked decrease in biogenic amines (NA, DA, and 5-HT) was also found in the brain of aged rats. In conclusion, our data suggest that increased oxidative stress, decline of antioxidant enzyme activities, altered AChE activity, and decreased biogenic amines level in the brain of aged rats may potentially be involved in diminished memory function.

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“…The lowest activity of AChE was reported as a sign of the most severe stages of dementia. A low activity of AChE existing in CSF of a non-demented individual may indicate a brain at risk, or that a person is in preclinical stage (16). It was also established that when cholinacetyltransferase and acetylcholinesterase activities were significantly reduced in cortex, the number of senile plaques rose (17,18).…”

Section: Discussionmentioning

confidence: 99%

Acetylcholinesterase Activity in the Mongolian Gerbil Brain after Acute Poisoning with Aluminum

Micić

Petronijević

2000

JAD

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ABSTRACT:The aim of the present study was to evaluate the acetylcholinesterase activity in the brain of adult gerbils (Meriones unguiculatus) treated with aluminum. AlCl 3 x 6H 2 O was given "per os" in the amount of 3.7 g/kg body weight. The animals were killed 24, 48, 72 and 96 hours after the treatment. The activities of acetylholinesterase in the mitochondrial and microsomal fractions of cortex, hippocampus and thalamus as well as plasma levels of aluminum were measured. Acetylcholinesterase activity was significantly reduced in the mitochondrial and microsomal fraction of all investigated structures. Decrease of the enzyme activity was observed in the first 24 hours, and it was most prominent 48 hours after the administration of aluminum in the mitochondrial fractions when the activity of the enzyme was 31%, 29% and 18.9% of the control value, and after 24 hours in the microsomal fractions when the activity of the enzyme was 43%, 48% and 32% of the control value in the cortex, hippocampus and thalamus, respectively. 96 hours after the administration of aluminum the activity of the enzyme was 63%, 57% and 31% of the value in the control group in mitochondrial, and 100%, 80% and 73% of the control value in microsomal fractions in cortex, hippocampus and thalamus. Plasma levels of aluminum were significantly elevated 24 hours after administration of aluminum. After 48 hours the values were doubled in comparison with the control, 72 hours later plasma concentrations of aluminum were decreased, and after 96 hours they reached the value in the control group. We can conclude that a single oral dose (LD50) of aluminum causes the changes in the brain acetylcholinesterase activity. The changes are still present when the aluminum concentration in plasma is normalized.

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The significance of the activity of CSF cholinesterases in dementias

Cited by 14 publications

References 89 publications

Age-Dependent Decline in Erythrocyte Acetylcholinesterase Activity: Correlation With Oxidative Stress

Age-Dependent Decline in Erythrocyte Acetylcholinesterase Activity: Correlation With Oxidative Stress

Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system

Acetylcholinesterase Activity in the Mongolian Gerbil Brain after Acute Poisoning with Aluminum

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