The significance of water metabolism in general pathology as demonstrated by experiments on the ear

Mygind, S. H.; Dederding, Dida

doi:10.3109/00016483209134883

Cited by 49 publications

(4 citation statements)

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“…Although Mygind and Dederding [37] indicated the importance of salt and water homeostasis in the treatment of MD even 6 years before Yamakawa [1] and Hallpike and Cairns [2] made their fundamental discovery of the distension of the endolymphatic compartment, histopathological characteristics of EH lead to the concept that malregulation of endolymph homeostasis is an underlying overaccumulation of the endolymph. Masuda [38] suggested that an increase in hormones of the posterior pituitary played a crucial role in the attack of MD.…”

Section: Commentmentioning

confidence: 99%

Hormonal Aspects of Ménière’s Disease on the Basis of Clinical and Experimental Studies

Takeda

Kakigi

et al. 2009

ORL

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Conclusions: Endolymph homeostasis is thought to be mediated by the vasopressin-aquaporin-2 (VP-AQP2) system in the inner ear. Endolymphatic hydrops, the morphological characteristics of Ménière’s disease (MD), seems to reflect the malregulation of the VP-AQP2 system in inner ear fluid. The elevation of plasma vasopressin (p-VP) level, which is often observed in MD and its related diseases, might be one of the causative factors underlying these diseases. Purpose of Review: Review of the role of the VP-AQP2 system in the inner ear fluid homeostasis and in the formation and development of endolymphatic hydrops. Recent Clinical and Experimental Findings: A clinical survey has revealed that the p-VP level is often elevated in MD and its related diseases and that the increase in the p-VP level was closely linked to vertigo attacks in MD. Experimental studies have revealed that proteins and mRNAs of aquaporin-2 and vasopressin type 2 receptor were expressed in the stria vascularis of the cochlea and the epithelium of the endolymphatic sac, and that the volume of the endolymphatic compartment was mediated by the activity of the VP-AQP2 system in the inner ear.

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Section: Commentmentioning

confidence: 99%

Hormonal Aspects of Ménière’s Disease on the Basis of Clinical and Experimental Studies

Takeda

Kakigi

et al. 2009

ORL

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“…The unanswered question of whether Meniere's disease is a disease in its own right, or simply a symptom-complex, has puzzled and frustrated surgeons for many years. Mygind and Dederding (1932) stated tbat 'Meniere's disease is not a disease sui generis, but a typical reaction of a predisposed labyrinth to an almost infinite series of exo-and endo-genic influences, which have, however, this in common, that they express themselves through the vessels, especially the capillaries'. Many modern otologists concur with this view, believing that metabolic, allergic and psychosomatic factors can produce endolymphatic hydrops and, that when all of these entities have been discovered, Meniere's 'disease' will cease to exist.…”

Section: Discussionmentioning

confidence: 99%

Metabolic investigations in Menière's disease

1979

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“…This has again brought to light the unanswered question of whether Meniere's disease is a disease in its own right or simply a symptom complex. Mygind and Dederding (1932) stated that 'Meniere's disease is not a disease suigeneris, but a typical reaction of a predisposed labyrinth to an almost infinite series of exo-and endo-genic influences, which have, however, this in common, that they express themselves through the vessels, especially the capillaries'. Many modern otologists concur with this view, believing that metabolic factors can produce endolymphatic hydrops and that when all of these entities have been discovered, Meniere's disease will cease to exist.…”

Section: Metabolic Investigations In Meniere's Diseasementioning

confidence: 99%