The site of action of aβ 2-receptor stimulating drug (Fenoterol) on antigen-induced bronchoconstriction

Zimmermann, I.; Almeida, A. A. Bugalho de; Ulmer, W. T.

doi:10.1007/bf02713698

Cited by 16 publications

(9 citation statements)

References 21 publications

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“…Die pro 100 ml AZV gemessene ösophageale Druckdifferenz entspricht der dynamischen Elastance (Edy"), die unter unseren Versuchsbedingungen mit den Strömungswiderständen in den Atemwegen kor reliert [Zimmermann et al, 1980b] wenn Edyn schon wieder abgesunken war. Der PGF2 a-Met-Wert zeigte ein weniger konstantes Verhalten, wenn auch doch ein relativ geringgradiger Anstieg der Plasma konzentrationen zu beobachten war.…”

Section: Methodikunclassified

Bedeutung des Nervus vagus, des Histamins, der Prostaglandine und der Katecholamine f ür die Atemwegsobstruktion

Zimmermann¹,

Peskar²,

Rasche³

et al. 1984

Respiration

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In three series of experiments, aerosols of acetylcholine, histamine, and Ascaris were administered in a maximal concentration before and after bilateral vagus transection. Vagotomy induced a clear reduction of the dynamic elastance increase by maintaining a constant breath volume. The persisting reaction of the dynamic elastance after vagotomy depends on the intensity of the reaction before vagus transection. Acetylcholine induced the largest reaction. Changes in epinephrine and norepinephrine were found to be variable, but an increase related to dynamic elastance increase could be assumed. Acetylcholine induced a maximal increase in thromboxane B₂, and Ascaris induced preferentially a maximal increase in the prostaglandin F₂α metabolite 15-Keto-13, 14-dihydro-PGF₂α. Vagotomy showed no influence on changes of thromboxane B₂, prostaglandin F₂α metabolite, or histamine in arterial plasma. The variability in changes of these metabolites may be the cause of the clinical differences in obstructive airway diseases.

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Section: Methodikunclassified

Bedeutung des Nervus vagus, des Histamins, der Prostaglandine und der Katecholamine f ür die Atemwegsobstruktion

Zimmermann¹,

Peskar²,

Rasche³

et al. 1984

Respiration

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“…Heart frequency (HF) was obtained from signals given by this intra-arterial catheter. APoes per 100 ml TV (APoes/100 ml TV) was used as an expression of dynamic elastance (Zimmermann et al 1980). The parameters were taken from a continuous recording immediately before, during, and immediately after substance administration.…”

Section: Methodsmentioning

confidence: 99%

The role of vagus nerve on histamine- and acetylcholine-induced bronchoconstriction (experiments on cats)

Zimmermann

Ulmer

1986

Res. Exp. Med.

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During administration of highly concentrated acetyclcholine and histamine aerosol (20-40 min), different effects on tidal volume, respiratory rate, and bronchial tone could be demonstrated. Inhalation after vagotomy neither showed changes in respiratory rate nor in tidal volume. These results point out the importance of the nervus vagus in case of bronchoconstriction caused by mediators. It is discussed to which degree vagus activity is required for the direct effect of different mediators in living animals.

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“…AP^j/100 ml tidal volume (AP^/lOO ml TV) was used as an expression of dynamic elasticity. This pa rameter was considered a reflection of changes in air way resistance [Zimmermann et al, 1980). After the animals were prepared, about 30-40 min were al lowed to reach a steady state.…”

Section: Methodsmentioning

confidence: 99%

Partial Sensory Denervation of the Upper Respiratory Tract on Allergen- and Histamine-Induced Bronchoconstriction

Zimmermann¹,

Almeida²,

Ulmer³

1984

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The influence of partial denervation of the upper part of the respiratory tract on histamine- and antigen-induced bronchoconstriction was investigated in a series of 12 boxer dogs. To achieve this purpose, the superior laryngeal, hypoglossal and glossopharyngeal nerves were sectioned. The prophylactic effect of unilateral transection of these nerves on antigen-induced bronchoconstriction originating in the upper respiratory tract could be demonstrated.

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The site of action of aβ 2-receptor stimulating drug (Fenoterol) on antigen-induced bronchoconstriction

Cited by 16 publications

References 21 publications

Bedeutung des Nervus vagus, des Histamins, der Prostaglandine und der Katecholamine f ür die Atemwegsobstruktion

Bedeutung des Nervus vagus, des Histamins, der Prostaglandine und der Katecholamine f ür die Atemwegsobstruktion

The role of vagus nerve on histamine- and acetylcholine-induced bronchoconstriction (experiments on cats)

Partial Sensory Denervation of the Upper Respiratory Tract on Allergen- and Histamine-Induced Bronchoconstriction

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