International audienceWe report the processes and results of statistical analysis on the ionospheric electron densitydata measured by the Detection of Electro-Magnetic Emissions Transmitted from Earthquake Regions(DEMETER) satellite over a period of 6 years (2005–2010), in order to investigate the correlation betweenseismic activity and equatorial plasma density variations. To simplify the analysis, three equatorial regionswith frequent earthquakes were selected and then one-dimensional time series analysis between thedaily seismic activity indices and the equatorial ionization anomaly (EIA) intensity indices, which representrelative equatorial electron density increase, were performed for each region. The statistically significantvalues of the lagged cross-correlation function, particularly in the region with minimal effects oflongitudinal asymmetry, indicate that some of the very large earthquakes with M > 5.0 in the low-latituderegion can accompany observable precursory and concurrent EIA enhancements, even though the seismicactivity is not the most significant driver of the equatorial ionospheric evolution. The physical mechanismsof the seismo-ionospheric coupling is consistent with our observation, and the possibility of earthquakeprediction using the EIA intensity variation is discussed