Splenic infarct (SI) is a rare clinical diagnosis typically characterized by symptoms of abdominal pain, nausea, and vomiting. Here we provide a unique case of SI, presenting as acute left-sided chest pain. This unusual presentation led us to incorrectly focus the initial investigation on diseases of cardiac origin. The resultant delay in correct diagnosis of Splenic Infarct and adequate treatment is described. This case highlights the need to consider SI in patients with acute chest pain, particularly in the presence of predisposing factors, such as hematological malignancy or autoimmune rheumatic diseases.