The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline

Fadhel, Sahar Rihan; Abdulla, Najwa I.; Sulaiman, Intidhar D.

doi:10.31351/vol25iss1pp42-49

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…The absorbance was measured, at 586 nm against the blank reagent. The results as it Figure (10) show that the ratio is 1:1. In the molar ratio approach, 2.25 mL of the standard drug solution in a series of volumetric flasks (10 ml) was transferred, and various volumes of (0.25-0.25) mL of 2.4-DNPH reagent solution, 2.25 mL of potassium Iodate (4.6×10 -3 M) and 0.25 mL of sodium hydroxide solution were added.…”

Section: Table (2): Accuracy and Precision Formentioning

confidence: 76%

Spectrophotometric Determination Of Anti-Ulcer Drug (Cimetidine) By 2.4-Dinitrophenylhydrazine Reagent

Hassoni¹,

Mashkour²

2022

Journal of Pharmaceutical Negative Results

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An innovative, simple, and sensitive spectrophotometric method was described for the determination of cimetidine in both its pureform and in pharmaceutical formulations. By oxidizing 2.4-dinitrophenylhydrazine (2.4-DNPH) and mixing it with cimetidine in analkaline solution, a brightly colored chromogen with a maximum absorption wavelength of 586 nm is created. After that,spectrophotometry was used to quantify the amount of cimetidine. Other analytical criteria, such as the ideal reaction circumstances,were evaluated. These criteria included variables like the volumes of 2.4-DNPH and potassium iodate, the amount of base, thecoupling reaction time, temperature, and the order in which the constituents of the final product are added. Beer's law is applied toconcentrations of (25–250) µg/mL-1 with correlation coefficient (R2) = 0.9964, molar absorptivity 353.276 (L.mol-1.cm-1), andSandell's law. The recommended method for locating cimetidine in pharmaceutical formulations worked well.

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Section: Table (2): Accuracy and Precision Formentioning

confidence: 76%

Spectrophotometric Determination Of Anti-Ulcer Drug (Cimetidine) By 2.4-Dinitrophenylhydrazine Reagent

Hassoni¹,

Mashkour²

2022

Journal of Pharmaceutical Negative Results

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“…OLZ shows some drug interactions when used with some combi- Spectrophotometric methods using UV-Vis. spectra have been developed for OLZ analysis with and without combinations (Ali & Elbashir, 2012;Fadhel et al, 2016;Ghanchivhora et al, 2017;Moura & Moita, 2012;Pradhan et al, 2014;Revanasiddappa & Deepakumari, 2014;Silva et al, 2017;Vekaria & Parmar, 2021). The literature work is presented in Table 1.…”

Section: Pharmacokineticsmentioning

confidence: 99%

A review of various analytical methods for the estimation of olanzapine: An antipsychotic drug

Reka

Sheikh

Almalki

et al. 2023

Biomedical Chromatography

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Olanzapine (OLZ) is an antipsychotic agent and is a thienobenzodiazepine derivative. It is used either in combination with other drugs like carbamazepine, simvastatin, and clozapine or as a single drug. The present work is mainly focused on various approaches for OLZ analysis in bulk drugs as well as on their pharmaceutical formulations. It is also focused on various bioanalytical methods used for analysis. Our survey showed that many analytical techniques were carried out using UV spectrophotometry, MS, LC–MS/MS techniques, and chromatographic techniques like HPLC and high‐performance thin layer chromatography in both bulk and solid dosage forms. Bioanalytical techniques were also performed using human plasma or serum. The analysis was carried out either for a single drug or for a combination of drugs. This review shows the rate of use of the different methodologies for OLZ analysis. A considerable amount of information was collected and utilized for the strategies.

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“…Salah satunya adalah komposit serat kulit pohon waru [5]. Komposit ini menggunakan serat kulit pohon waru sebagai reinforcement yang dikombinasikan dengan resin sintetis sebagai matriks [6].…”

Section: Pendahuluanunclassified

Analisa Tensile Strength Komposit Serat Kulit Pohon Waru dengan Kombinasi Serat Karbon Kevlar Sebagai Material Reinforcement

Stefan Enus,

Soebiyakto,

Rizki Fadhillah

et al. 2023

infotekmesin

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In increasing the tensile strength of the waru tree bark fiber composite (Hibiscus tiliaceus), it is necessary to have a combination of reinforcement used in the composite material. One of the reinforcement materials that can be combined is carbon fiber kevlar. Kevlar carbon fiber has several advantages, including low density, absorbing vibrations well, and it is resistant to chemical solutions. The specific objectives of this study were to determine the maximum strain stress, modulus of elasticity, and fracture analysis of hibiscus bark fiber composites with a combination of kevlar carbon fiber as a reinforcement material. The independent variable in the study was comparing the composite with the different reinforcement materials used, including 100% hibiscus (Hibiscus tiliaceus) bark fiber, 100% kevlar carbon fiber, 50% combination fiber of hibiscus (Hibiscus tiliaceus) bark, and 50% kevlar carbon. The process of making composites uses the vacuum infusion resin method with specimens referring to the ASTM D638-03 type I standard. The results of this study are that combining kevlar carbon fiber as a reinforcement material can improve the mechanical properties in terms of the tensile strength of the hibiscus tree bark fiber composite.

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The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline

Cited by 4 publications

References 5 publications

Spectrophotometric Determination Of Anti-Ulcer Drug (Cimetidine) By 2.4-Dinitrophenylhydrazine Reagent

Spectrophotometric Determination Of Anti-Ulcer Drug (Cimetidine) By 2.4-Dinitrophenylhydrazine Reagent

A review of various analytical methods for the estimation of olanzapine: An antipsychotic drug

Analisa Tensile Strength Komposit Serat Kulit Pohon Waru dengan Kombinasi Serat Karbon Kevlar Sebagai Material Reinforcement

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