2022
DOI: 10.1016/j.bcp.2022.115161
|View full text |Cite
|
Sign up to set email alerts
|

The SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl) isonicotinamide (SRPIN340) increases the immune response against metastatic melanoma in mice

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
7
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 7 publications
(7 citation statements)
references
References 52 publications
0
7
0
Order By: Relevance
“…Several SRPK1/2-related roles in cancer have been reported, such as angiogenesis (Gammons et al, 2014), proliferation (Jang et al, 2008), cell migration and EMT (Wang et al, 2017), metastasis (van Roosmalen et al, 2015Zhuo et al, 2018), lipid biosynthesis (Lee et al, 2017), genome stability maintenance (Sridhara et al, 2017), and drug resistance mediation (Wang et al, 2019). We previously demonstrated the anti-metastatic effect of pharmacological inhibitors targeting the SRPK1/2 family in melanoma (Gammons et al, 2014;Moreira et al, 2018;Moreira et al, 2022). As selective SRPK pharmacological inhibitors are still unknown, the role of SRPK1 or SRPK2 activity in melanoma remains obscure.…”
Section: Discussionmentioning
confidence: 97%
See 3 more Smart Citations
“…Several SRPK1/2-related roles in cancer have been reported, such as angiogenesis (Gammons et al, 2014), proliferation (Jang et al, 2008), cell migration and EMT (Wang et al, 2017), metastasis (van Roosmalen et al, 2015Zhuo et al, 2018), lipid biosynthesis (Lee et al, 2017), genome stability maintenance (Sridhara et al, 2017), and drug resistance mediation (Wang et al, 2019). We previously demonstrated the anti-metastatic effect of pharmacological inhibitors targeting the SRPK1/2 family in melanoma (Gammons et al, 2014;Moreira et al, 2018;Moreira et al, 2022). As selective SRPK pharmacological inhibitors are still unknown, the role of SRPK1 or SRPK2 activity in melanoma remains obscure.…”
Section: Discussionmentioning
confidence: 97%
“…We downloaded clinical and pre-processed single-cell RNA sequencing (scRNA-Seq) public data (Jerby-Arnon et al, 2018) of patients with melanoma and processed it according to the scripts available in the GitHub repository "SRPK at single-cell resolution" (Rapozo and Santos, 2022a). We used the previous annotation of the Seurat object (Butler et al, 2018) to identify all the cells of the tumor microenvironment (TME) (Moreira et al, 2022). Melanoma is largely related to DNA copy number changes (Shain et al, 2015).…”
Section: Single-cell Analysismentioning
confidence: 99%
See 2 more Smart Citations
“…Its phosphorylated isoform, SRPK1, controls pre-mRNA splicing by regulating pro-angiogenic isoforms [ 31 ]. In addition, an increased number of immune cells were observed in biopsies of mice treated with SRPK1/2 pharmacological inhibitors of metastatic melanoma [ 32 34 ]. In vitro assays indicated that inhibitors increase immunological sensitivity by intensifying the expression of antigen-presenting major histocompatibility complex (MHC) I and MHC II molecules and splenocyte recruitment [ 34 ].…”
Section: Introductionmentioning
confidence: 99%