The Stability of Blood Gas Parameters Depends on Leukocyte Counts

Vaudran, Lucie; Pekar, Jean‐David; Grzych, Guillaume; Maboudou, Patrice

doi:10.3343/alm.2021.41.5.502

Ann Lab Med

2021

DOI: 10.3343/alm.2021.41.5.502

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The Stability of Blood Gas Parameters Depends on Leukocyte Counts

Lucie Vaudran¹,

Jean‐David Pekar²,

Guillaume Grzych³

et al.

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Cited by 2 publications

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“…The flow chart proposed by the Vaudran, et al . [ 1 ] seems very consistent and useful in daily clinical practice. Nevertheless, when leukocyte count cannot be determined, we still recommend storing samples at 0–3.9°C for a maximum of 45 minutes.…”

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confidence: 96%

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Reply to the Letter “The Stability of Blood Gas Parameters Depends on Leukocyte Count”

Arbiol‐Roca

Imperiali

2021

Ann Lab Med

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confidence: 96%

“…We would like to thank Vaudran, et al . [ 1 ] for their letter in response to our article “Stability of pH, blood gas partial pressure, hemoglobin oxygen saturation fraction, and lactate concentration” [ 2 ]. We agree with the issues raised by the authors.…”

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Reply to the Letter “The Stability of Blood Gas Parameters Depends on Leukocyte Count”

Arbiol‐Roca

Imperiali

2021

Ann Lab Med

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Impact of storage temperature and time before analysis on electrolytes (Na⁺, K⁺, Ca²⁺), lactate, glucose, blood gases (pH, pO₂, pCO₂), tHb, O₂Hb, COHb and MetHb results

Puravet

Rieu

Phere

et al. 2023

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives The objective of our study is to evaluate the effect of storage temperature and time to analysis on arterial blood gas parameters in order to extend the CLSI recommendations. Methods Stability of 12 parameters (pH, pCO₂, pO₂, Na+, K+, Ca2+, glucose, lactate, hemoglobin, oxyhemoglobin, carboxyhemoglobin, methemoglobin) measured by GEM PREMIER™ 5000 blood gas analyzer was studied at room temperature and at +4 °C (52 patients). The storage times were 30, 45, 60, 90 and 120 min. Stability was evaluated on the difference from baseline, the difference from the analyte-specific measurement uncertainty applied to the baseline value, and the impact of the variation on the clinical interpretation. Results At room temperature, all parameters except the lactate remained stable for at least 60 min. A statistically significant difference was observed for pH at T45 and T60 and for pCO2 at T60 without modification of clinical interpretation. For lactate, clinical interpretation was modified from T45 and values were outside the range of acceptability defined by the measurement uncertainty. All parameters except pO2 remained stable for at least 120 min at +4 °C. Conclusions A one-hour transport at room temperature is compatible with the performance of all the analyses studied except lactate. If the delay exceeds 30 min, the sample should be placed at +4 °C for lactate measurement. If the samples are stored in ice, it is important to note that the pO2 cannot be interpreted.

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The Stability of Blood Gas Parameters Depends on Leukocyte Counts

Cited by 2 publications

References 7 publications

Reply to the Letter “The Stability of Blood Gas Parameters Depends on Leukocyte Count”

Reply to the Letter “The Stability of Blood Gas Parameters Depends on Leukocyte Count”

Impact of storage temperature and time before analysis on electrolytes (Na⁺, K⁺, Ca²⁺), lactate, glucose, blood gases (pH, pO₂, pCO₂), tHb, O₂Hb, COHb and MetHb results

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The Stability of Blood Gas Parameters Depends on Leukocyte Counts

Cited by 2 publications

References 7 publications

Reply to the Letter “The Stability of Blood Gas Parameters Depends on Leukocyte Count”

Reply to the Letter “The Stability of Blood Gas Parameters Depends on Leukocyte Count”

Impact of storage temperature and time before analysis on electrolytes (Na+, K+, Ca2+), lactate, glucose, blood gases (pH, pO2, pCO2), tHb, O2Hb, COHb and MetHb results

Contact Info

Product

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Impact of storage temperature and time before analysis on electrolytes (Na⁺, K⁺, Ca²⁺), lactate, glucose, blood gases (pH, pO₂, pCO₂), tHb, O₂Hb, COHb and MetHb results