The Study of Airborne Particulate Matter in Dalnegorsk Town

Холодов, А. С.; Tarasenko, Irina A.; Zinkova, E.; Teodoro, Michele; Docea, Anca Oana; Calina, Daniela; Tsatsakis, Aristidis; Golokhvast, Kirill S.

doi:10.3390/ijerph18179234

Cited by 10 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Heavy metals include naturally occurring chemicals with high atomic weight and density. Typically, these chemicals can be conveyed with particulate matter especially in urban areas and then reach the water and the soil (91). Several studies on humans or in vitro models suggest that HMs exposure can alter the composition and integrity of the GM (92)(93)(94)(95).…”

Section: Metalsmentioning

confidence: 99%

Role-Playing Between Environmental Pollutants and Human Gut Microbiota: A Complex Bidirectional Interaction

et al. 2022

Self Cite

View full text Add to dashboard Cite

There is a growing interest in the characterization of the involvement of toxicant and pollutant exposures in the development and the progression of several diseases such as obesity, diabetes, cancer, as well as in the disruption of the immune and reproductive homeostasis. The gut microbiota is considered a pivotal player against the toxic properties of chemicals with the establishment of a dynamic bidirectional relationship, underlining the toxicological significance of this mutual interplay. In fact, several environmental chemicals have been demonstrated to affect the composition, the biodiversity of the intestinal microbiota together with the underlining modulated metabolic pathways, which may play an important role in tailoring the microbiotype of an individual. In this review, we aimed to discuss the latest updates concerning the environmental chemicals–microbiota dual interaction, toward the identification of a distinctiveness of the gut microbial community, which, in turn, may allow to adopt personalized preventive strategies to improve risk assessment for more susceptible workers.

show abstract

Section: Metalsmentioning

confidence: 99%

Role-Playing Between Environmental Pollutants and Human Gut Microbiota: A Complex Bidirectional Interaction

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Other cigarettes smoke constituents are present in either a gas phase or particulate phase: Particulate-phase components include 4-aminobiphenyl, carbazole (tumour accelerators), indole, nicotine (ganglion stimulator and depressor), trace elements (carcinogens), catechol, cresol, phenol, polynuclear hydrocarbons, and tar [ 11 , 14 ] ( Figure 1 ) gas phase contains vinyl chloride (carcinogens), hydrazine, oxides of nitrogen, nitrosamines, formaldehyde, ammonia, acrolein, acetaldehyde, hydrocyanic acid, and carbon monoxide (impairs oxygen utilization and transport) [ 11 , 14 ] ( Figure 1 ). …”

Section: Nicotine and Other Cigarette Smoke Constituentsmentioning

confidence: 99%

“…Particulate-phase components include 4-aminobiphenyl, carbazole (tumour accelerators), indole, nicotine (ganglion stimulator and depressor), trace elements (carcinogens), catechol, cresol, phenol, polynuclear hydrocarbons, and tar [ 11 , 14 ] ( Figure 1 )…”

Section: Nicotine and Other Cigarette Smoke Constituentsmentioning

confidence: 99%

See 1 more Smart Citation

Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis

Jain

Chaudhary

Varshney

et al. 2021

Journal of Oncology

Self Cite

View full text Add to dashboard Cite

Smoking a cigarette generates over 4000 chemicals that have a deleterious impact on each part of the human body. It produces three main severe effects on the liver organ: oncogenic, immunological, and indirect or direct toxic effects. It results in the production of cytotoxic substances, which raises fibrosis and necro-inflammation. Additionally, it also directs the production of pro-inflammatory cytokines tumour necrosis factor alfa (TNF-α) and interleukins (IL-1β, IL-6) that will be responsible for the chronic liver injury. Furthermore, it gives rise to secondary polycythemia and successively raises the turnover and mass of red cells, which might be a common factor responsible for the development of oxidative stress in the liver due to iron overload. It also produces chemicals that are having oncogenic properties and raises the risk of liver cancer especially in sufferers of chronic hepatitis C. Smoking modulates both humoral and cell-mediated responses by restricting the proliferation of lymphocytes and inducing their apoptosis and ultimately decreasing the surveillance of cancer cells. Moreover, it has been determined that heavy smoking impacts the response of hepatitis C patients to interferon (IFN) therapy through different mechanisms, which can be improved by phlebotomy. Efforts are being made in different nations in decreasing the prevalence of smoking to improve premature death and ill effects of their nation’s individuals.

show abstract

“…Some of the inheritably received genetic flaws (such as mutations in BRCA1 or BRCA2) and infectious diseases may raise the risks of cancer. Environmental pollution, irradiation or poor lifestyle, for example, smoking can enhance DNA damage and thus can lead to cancer [ 4 , 49 , 51 , 94 , 104 ]. Damaged DNA can be repaired by cellular DNA repair machinery, and in case of severe DNA insult, if the repair mechanism fails, cells are led to death by apoptosis [ 24 , 29 , 47 , 92 ].…”

Section: Introductionmentioning

confidence: 99%

Recent advances and limitations of mTOR inhibitors in the treatment of cancer

et al. 2022

Self Cite

View full text Add to dashboard Cite

The PI3K-Akt-mechanistic (formerly mammalian) target of the rapamycin (mTOR) signaling pathway is important in a variety of biological activities, including cellular proliferation, survival, metabolism, autophagy, and immunity. Abnormal PI3K-Akt-mTOR signalling activation can promote transformation by creating a cellular environment conducive to it. Deregulation of such a system in terms of genetic mutations and amplification has been related to several human cancers. Consequently, mTOR has been recognized as a key target for the treatment of cancer, especially for treating cancers with elevated mTOR signaling due to genetic or metabolic disorders. In vitro and in vivo, rapamycin which is an immunosuppressant agent actively suppresses the activity of mTOR and reduces cancer cell growth. As a result, various sirolimus-derived compounds have now been established as therapies for cancer, and now these medications are being investigated in clinical studies. In this updated review, we discuss the usage of sirolimus-derived compounds and other drugs in several preclinical or clinical studies as well as explain some of the challenges involved in targeting mTOR for treating various human cancers.

show abstract

The Study of Airborne Particulate Matter in Dalnegorsk Town

Cited by 10 publications

References 27 publications

Role-Playing Between Environmental Pollutants and Human Gut Microbiota: A Complex Bidirectional Interaction

Role-Playing Between Environmental Pollutants and Human Gut Microbiota: A Complex Bidirectional Interaction

Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis

Recent advances and limitations of mTOR inhibitors in the treatment of cancer

Contact Info

Product

Resources

About