The study of routine laboratory factors in children with mycoplasma pneumoniae pneumonia: serum uric acid may have anti‐inflammatory effect

Chen, Pan; Chen, Yanjie; Wang, Shaosheng; Li, Ming; Qu, Shen

doi:10.1002/jcla.24026

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…According to the results, children with bronchitis and pneumonia have a higher level of WBC and higher expression of inflammatory factors such as CRP, IL-6, and TNF-α. After the proper treatment, the four indicators have significantly decreased [16,17]. Moreover, the treatment with ambroxol hydrochloride combined with amoxicillin potassium clavulanate combination resulted in lower WBC and inflammatory factors as compared with amoxicillin potassium clavulanate combination, suggesting a prominent efficacy of ambroxol hydrochloride combined with amoxicillin potassium clavulanate combination in the treatment of bronchitis pneumonia in children.…”

Section: Discussionmentioning

confidence: 96%

Efficacy of Ambroxol Hydrochloride Combined with Amoxicillin Potassium Clavulanate Combination on Children with Bronchopneumonia and Its Impact on the Level of Inflammatory Factors

Zhu

Wei

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The goal of the present study was to examine the effect of ambroxol hydrochloride combined with amoxicillin potassium clavulanate combination on children with bronchopneumonia and its influence on the level of inflammatory factors. Methods. From January 2018 to June 2019, 100 children with bronchopneumonia admitted to the Pediatric Department of Nanjing Pukou District Hospital of Traditional Chinese Medicine were enrolled as the study subjects. The children were assigned either to an observation group or a control group in a ratio of 1:1 using the random alphabet method. The observation group was treated with ambroxol hydrochloride plus amoxicillin potassium clavulanate combination, and the control group was treated with amoxicillin potassium clavulanate combination. The therapeutic efficiency and serum white blood cells (WBC), C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-a (TNF-α) were compared between the two groups. Results. Regarding the effective rate of treatment, the observation group (94%) was observed to be notably higher as compared to the control group (84%). The levels of WBC, CRP, IL-6, and TNF-α were reported to be significantly lower in the two groups after treatment. The WBC, CRP, IL-6, and TNF-α after treatment in the observation group were lower than those in the control group. The time for clinical symptoms to disappear of fever, cough, asthma, and pulmonary rales was all shorter in the observation group. Conclusion. The findings of the present study demonstrate that ambroxol hydrochloride combined with amoxicillin potassium clavulanate combination might be a reliable approach for the treatment of bronchopneumonia in children. It can synergistically relieve inflammation with high safety profiles.

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Section: Discussionmentioning

confidence: 96%

Efficacy of Ambroxol Hydrochloride Combined with Amoxicillin Potassium Clavulanate Combination on Children with Bronchopneumonia and Its Impact on the Level of Inflammatory Factors

Zhu

Wei

Liu

2022

Evidence-Based Complementary and Alternative Medicine

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“…The mechanism of the reduced serum uric acid levels in RMPP patients is unknown.The study found that the concentration of uric acid in respiratory epithelial tissue uid was high, and the uric acid of respiratory epithelial lining uid played the antioxidant effect of together with other endogenous antioxidants and ascorbic acid (22).Uric acid was found to act as an endogenous modulator of innate immunity, so it is tempting to speculate that low levels of serum uric acid may exacerbate the cytokine storm during COVID-19 (23,24).Recent evidence suggests that acute and severe hypouricaemia induced in healthy individuals causes endothelial cell dysfunction (25). Recently, researchers have focused on serum uric acid levels in COVID-19, believing that hyperuricemia in COVID-19 patients may lead to acute kidney injury and adverse outcome(26).A most recent clinical study showed that serum uric acid exhibits protective effects in the pediatric MPP process, with an anti-in ammatory effect on (27). All the above suggest that reduced serum uric acid level is a risk factor for disease, but the speci c mechanism needs further study.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a nomogram to predict refractory Mycoplasma pneumoniae pneumonia

Shen

Sun

2023

Preprint

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Background: This study aims to construct a risk prediction model based on clinical manifestations, laboratory blood indicators and radiological fndings to help clinicians identify patients who are at high risk of refractory mycoplasma pneumoniae pneumonia. Materials and methods: We retrospectively analyzed the medical records of 369 children with MPP.The data collected included demographics, clinical data ,laboratory findings and imaging data. Descriptive statistical analysis, involving numerous variables, was followed by univariate and multivariate logistic regression analysis.Subsequently,the clinical prediction model was constructed and underwent internal validation. Results: The clinical prediction model was constructed from these eight variables included fever duration,Pleural effussion,WBC,NEP,CRP, LDH,NLR and SUA.The developed nomogram, which has a satisfactory level of accuracy and good calibration, can be utilized to predict RMPP patients. Conclusion: Fever duration more than 10.5 days,Pleural effussion,WBC＞10.13×109/L,NEP＞6.43×109/L,CRP＞29.45mg/L,LDH＞370.50U/L,NLR＞3.47 and SUA＜170.5 umol/ml was early predictive model of RMPP.The developed nomogram, which has a satisfactory level of accuracy and good calibration, can be utilized to predict RMPP patients.

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“… 47 , 48 Another study demonstrated serum UA exerted anti-inflammation and protective effects on the mycoplasma pneumoniae pneumonia in children. 49 The ability of UA to reduce oxidative stress and inflammation is well established in pneumonia. In an earlier study, we found that serum UA was a protective factor for in-hospital pneumonia after ICH in a large population.…”

Section: Discussionmentioning

confidence: 99%

Uric Acid and Clinical Outcomes in Young Patients with Ischemic Stroke

Liu¹,

Liu²,

Jia³

et al. 2022

NDT

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Background and Purpose There is limited available evidence for the relationship between uric acid (UA) levels and ischemic stroke in young adults. We aimed to explore the association between UA levels and acute ischemic stroke (AIS) in young patients. Materials and Methods This was a prospective and observational study. We recruited young patients aged 18–45 years with AIS at our tertiary hospital. Patients were categorized into four groups according to quartiles of UA levels. The primary outcome was functional outcome at 3 months. The secondary outcomes included stroke severity, in-hospital complications, and functional outcome at discharge. Modified Rankin Scale (mRS) scores were used to assess functional outcome as poor (mRS=2-6) or favorable(mRS=0-1). Results A total of 636 patients were enrolled in the current analysis. The four groups were defined as follows: Q1≤289.8 µmol/L, 289.8 µmol/ L421 µmol/L. Multiple logistic regression analysis showed that UA levels were not significantly predictive of functional outcome either at discharge or at 3 months after AIS. However, compared to Q1, higher UA levels were significantly negatively associated with the rate of moderate-severe stroke (NIHSS≥5) at admission (p for trend =0.016). Furthermore, a reduction in the risk for in-hospital pneumonia was significantly associated with higher UA levels compared to Q1 ( P for trend < 0.0001). Conclusion Serum UA was a protective factor for stroke severity and in-hospital pneumonia after AIS in young patients. However, we were unable to identify the predictive significance of UA for functional outcome either at discharge or at 3 months after AIS.

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The study of routine laboratory factors in children with mycoplasma pneumoniae pneumonia: serum uric acid may have anti‐inflammatory effect

Cited by 6 publications

References 35 publications

Efficacy of Ambroxol Hydrochloride Combined with Amoxicillin Potassium Clavulanate Combination on Children with Bronchopneumonia and Its Impact on the Level of Inflammatory Factors

Efficacy of Ambroxol Hydrochloride Combined with Amoxicillin Potassium Clavulanate Combination on Children with Bronchopneumonia and Its Impact on the Level of Inflammatory Factors

Development and validation of a nomogram to predict refractory Mycoplasma pneumoniae pneumonia

Uric Acid and Clinical Outcomes in Young Patients with Ischemic Stroke

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