The surface energy of various biomaterials coated with adhesion molecules used in cell culture

Harnett, Elaine M.; Alderman, J.; Wood, Terri

doi:10.1016/j.colsurfb.2006.11.021

Cited by 260 publications

(201 citation statements)

References 19 publications

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“…Early Cell and bacteria adhesion behavior is linked to wettabililty and SFE, too [27][28][29]. This influence is mainly due to the presence of hydrophilic or hydrophobic chemical groups of the surface.…”

Section: Discussionmentioning

confidence: 99%

Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation

Godoy-Gallardo

Guillem-Marti

Sevilla

et al. 2016

Materials Science and Engineering: C

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Bacterial infection in dental implants along with osseointegration failure usually leads to loss of the device. Bioactive molecules with antibacterial properties can be attached to titanium surfaces with anchoring molecules such as silanes, preventing biofilm formation and improving osseointegration. Properties of silanes as molecular binders have been thoroughly studied, but research on the biological effects of these coatings is scarce. The aim of the present study was to determine the in vitro cell response and antibacterial effects of triethoxysilypropyl succinic anhydride (TESPSA) silane anchored on titanium surfaces. X-ray photoelectron spectroscopy confirmed a successful silanization. The silanized surfaces showed no cytotoxic effects. Gene expression analyses of Sarcoma Osteogenic (SaOS-2) osteoblast-like cells cultured on TESPSA silanized surfaces reported a remarkable increase of biochemical markers related to induction of osteoblastic cell differentiation. A manifest decrease of bacterial adhesion and biofilm formation at early stages was observed on treated substrates, while favoring cell adhesion and spreading in bacteria-cell co-cultures.Surfaces treated with TESPSA could enhance a biological sealing on implant surfaces against bacteria colonization of underlying tissues. Furthermore, it can be an effective anchoring platform of biomolecules on titanium surfaces with improved osteoblastic differentiation and antibacterial properties.

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Section: Discussionmentioning

confidence: 99%

Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation

Godoy-Gallardo

Guillem-Marti

Sevilla

et al. 2016

Materials Science and Engineering: C

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“…The number of cells differs significantly between Petri dishes and silicon chips. This can be explained by the difference in surface properties [27]. On the other hand, no significant effect on cell adhesion was noticed between uncoated and fibronectin-coated silicon chips.…”

Section: Biological Experimentsmentioning

confidence: 82%

Capillary-valve-based platform towards cell-on-chip mechanotransduction assays

Hausherr

Majd

Joss

et al. 2013

Sensors and Actuators B: Chemical

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a b s t r a c tReliable in vitro models are required to understand the ability of cells to respond and adapt to mechanical stimuli. To mimic and interface with the microenvironment, lab-on-a-chip devices and microelectromechanical systems (MEMS) provide excellent options. However, little effort has been done in combining them. To address this shortcoming, we have developed a versatile microengineered platform which consists of two parts: an electrostatically actuated MEMS device used for mechanobiology assays, and a fluidic system for cell culture. A capillary valve allows inserting a silicon chip horizontally in the culture medium without leakage and without wetting of the electrostatic microactuators. The platform is designed for mechanotransduction assay on cells and aims specifically human mesenchymal stem cells. The proof of principle of the platform was performed by stable and long-term cultures of rat fibroblasts. We could also study the effect of periodic stress at various excitation frequencies.

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“…This is due to the multicomponent nature of adhesion and the way in which surface thermodynamics enables such a multi-component system to be efficiently and sufficiently analysed. When accounting for adhesion it is also usually necessary to consider the wettability characteristics of the material and it has been shown that this factor can aid as a potential prediction mechanism for biological adhesion [1,3,6,42]. From this, the surface free energy of a material, along with the characteristic resulting contact angle evaluated with a liquid, can be directly related to the determination of bioactivity and cell adhesion.…”

Section: The Role Of Wettability In Biological and Microbiological Admentioning

confidence: 99%

“…This being said, there is an increasing interest in surface treatment/engineering of materials specifically regarding manipulating tissue engineering [1][2][3][4][5][6][7][8][9] and bacterial adhesion [10][11][12][13][14]. In a generalized sense, the development of technologies for the manipulation of biological and microbiological adhesion can be viewed in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

Surface Treatments to Modulate Bioadhesion: A Critical Review

Waugh¹,

Toccaceli²,

Gillett³

et al. 2016

rev adhes adhesives

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On account of the recent increase in importance of biological and microbiological adhesion in industries such as healthcare and food manufacturing many researchers are now turning to the study of materials, wettability and adhesion to develop the technology within these industries further. This is highly significant as the stem cell industry alone, for example, is currently worth £3.5 million in the United Kingdom (UK) alone. This paper reviews the current state-of-the-art techniques used for surface treatment with regards to modulating biological adhesion including laser surface treatment, plasma treatment, micro/nano printing and lithography, specifically highlighting areas of interest for further consideration by the scientific community. What is more, this review discusses the advantages and disadvantages of the current techniques enabling the assessment of the most attractive means for modulating biological adhesion, taking in to account cost effectiveness, complexity of equipment and capabilities for processing and analysis.

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The surface energy of various biomaterials coated with adhesion molecules used in cell culture

Cited by 260 publications

References 19 publications

Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation

Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation

Capillary-valve-based platform towards cell-on-chip mechanotransduction assays

Surface Treatments to Modulate Bioadhesion: A Critical Review

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