The Susceptibility of Staphylococcus aureus and Klebsiella pneumoniae to Naturally Derived Selected Classes of Flavonoids

Bodenstein, Johannes; Toit, Karen du

doi:10.5772/47948

Cited by 7 publications

(6 citation statements)

References 18 publications

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“…Both of these bacteria commonly colonise the upper respiratory tract, which is a part of the body notable for significance in pathogenesis of infections and epidemiology. This is in line with a report from Bodenstein and Du Toit [13] on the evaluation of the susceptibility of these microorganisms to selected classes of flavonoids.…”

Section: Discussionsupporting

confidence: 73%

Evaluation of the Types of Bacteria in the Blood of HIV-1 Patients Attending ART Clinic at the FMC Owo, Nigeria and their Antibiogram Profile

Oladosu¹,

Adebolu²,

Oladunmoye³

2016

HIV Curr Res

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In this investigation, the types of bacteria present in the blood of HIV-1 positive individuals attending the Antiretroviral Therapy clinic at a tertiary healthcare centre in Southwest, Nigeria and their antibiogram profile were assessed. A total number of Five Hundred confirmed HIV-1 Positive Patients were recruited for this study. Their blood was collected and subjected to standard microbiological techniques to isolate and identify the types of bacteria present and also determine the antibiogram profile of the isolates.

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Section: Discussionsupporting

confidence: 73%

Evaluation of the Types of Bacteria in the Blood of HIV-1 Patients Attending ART Clinic at the FMC Owo, Nigeria and their Antibiogram Profile

Oladosu¹,

Adebolu²,

Oladunmoye³

2016

HIV Curr Res

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“…The role of phytochemicals in wound healing is also supported by different studies. For instance, tannins are seen to be active detoxifying agents and inhibit bacterial growth [ 35 ]; terpenoids promote the wound healing process mainly due to their astringent and antimicrobial property [ 36 ]; flavonoids are potent antioxidants, free radical scavengers [ 28 , 32 ]. Polyphenols and flavonoids (prevent the synthesis of prostaglandins) possess anti-inflammatory properties and have antimicrobial activities [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae)

Demilew

Adinew

Asrade

2018

Evidence-Based Complementary and Alternative Medicine

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Background Medicinal plants play indispensable roles to treat various ailments. Acanthus polystachyus is one of the medicinal plants used traditionally for treatment of wounds. However, there were no scientific reports documented so far on the wound healing activities of this plant. Thus, the present study provides a scientific evaluation for the wound healing potential of the crude extract of A. polystachyus leaves. Methods The crude extraction was carried out using 80% methanol. The crude extract was prepared in 5% (w/w) and 10% (w/w) ointment and evaluated for wound healing activity using excision, infected, and incision wound models in Swiss albino mice. Results Both 5% and 10% (w/w) ointments significantly reduced period of epithelialization and increased wound contraction rate and tensile strength compared to the negative control group (P < 0.05). The wound healing activity of 10% (w/w) ointment treated group was greater than 5% (w/w) and nitrofurazone ointment treated groups in S. aureus infected wound model. Conclusion These results demonstrate that the crude extract of A. polystachyus leaves possesses wound healing activities. This justifies the traditional claimed use of the plant for treating uninfected and infected wounds caused by S. aureus.

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“…For example, tannins have been shown as an active detoxifying agent and also inhibit bacterial growth [24]. Also the astringent and antimicrobial property of terpenoids have been said to promote the wound healing process [25] and flavonoids are said to be potent antioxidants, free radical scavengers [14,26,27]. Polyphenols and flavonoids which prevent the synthesis of prostaglandins are said to possess anti-inflammatory properties and have antimicrobial activities [28].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and wound healing properties of the methanol extract of Ficus platyphylla Del. (Moraceae) stem bark

Sheidu¹,

Zezi²,

Ahmed³

et al. 2021

J. Pharm Bio.

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Ficus platyphylla (Fp) has been used in Nigerian traditional medicine for the management of pain, ulcer, wound, epilepsy and inflammation. The efficacy of its gum from the stem bark for the management of wound has been widely acclaimed among the Hausa communities of Northern Nigeria and therefore, this study was aimed at examining the antimicrobial and wound healing potential of methanol extract of F. platyphylla stem bark (MEFpSB) in order to provide scientific basis for its antimicrobial and wound healing properties. Preliminary phytochemical screening was done and antimicrobial activity using some pathogenic micro-organisms were evaluated following its wound healing effectiveness in Wistar rats using the model of superficial skin excision wound. Data were analysed using one-way analysis of variance (ANOVA) followed by Dunnet’s t-test. The results of preliminary phytochemical screeningrevealed the presence of carbohydrate, cardiac glycosides, saponins, flavonoids, triterpenes, tannins, alkaloids with anthraquinones absent. The extract showed antimicrobial activity on Staphylococcus aureus, Corynebacterium ulcerans, Escherichia coli, Klebsiella pneumonia and Salmonella typhi and significant (p< 0.05, p< 0.001) decrease in wound measurement for 11 days. This study demonstrated that MEFpSB possesses antimicrobial activity with wound healing properties that justifies the ethno-medicinal use of the plant in wound/ulcer healings. Keywords: Wound healing; Antimicrobial; Ficus platyphylla; Formulation; Topical

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The Susceptibility of Staphylococcus aureus and Klebsiella pneumoniae to Naturally Derived Selected Classes of Flavonoids

Cited by 7 publications

References 18 publications

Evaluation of the Types of Bacteria in the Blood of HIV-1 Patients Attending ART Clinic at the FMC Owo, Nigeria and their Antibiogram Profile

Evaluation of the Types of Bacteria in the Blood of HIV-1 Patients Attending ART Clinic at the FMC Owo, Nigeria and their Antibiogram Profile

Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae)

Antimicrobial and wound healing properties of the methanol extract of Ficus platyphylla Del. (Moraceae) stem bark

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