The swollen polymer network hypothesis: Quantitative models of hydrogel swelling, stiffness, and solute transport

Richbourg, Nathan R.; Peppas, Nicholas A.

doi:10.1016/j.progpolymsci.2020.101243

Cited by 210 publications

(212 citation statements)

References 62 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…It follows from eqn (33) that P is close to unity (which implies that the model (16), (19), (28) and (30) coincides with the conventional relations for swelling of a TR gel in a binary solvent) when the equilibrium degree of swelling Q is sufficiently large, that is below the volume phase transition temperature T c .…”

mentioning

confidence: 64%

“…Eqn (19) means that G 2 vanishes when a gel is in the swollen state, and the modulus grows (due to aggregation of hydrophobic segments) with h when the gel is in the collapsed state.…”

Section: Swelling Of Tr Gels In Solutions Of Additivesmentioning

confidence: 99%

“…As the analysis focuses on a narrow interval of temperatures near T c , the actual temperature T is replaced with a xed temperature T 0 in the thermodynamic factor k B T. When the FH parameter c is treated as a function of temperature T only, this approach results in rather poor agreement with experimental swelling diagrams. 19 To improve the quality of tting, this coefficient is traditionally replaced with an effective FH parameter c eff , which is presumed to depend on two arguments, T and f n . Adopting an analytical expression for c eff (as a polynomial 20 or rational 21 function of f n with temperature-dependent coefficients), an acceptable agreement can be reached between experimental data and results of simulation.…”

Section: Introductionmentioning

confidence: 99%

“…The governing eqn (16), (19), (28), (30) together with eqn (32) for the critical temperature T c express the unknown parameters Q and T c in terms of the volume fraction of additives in the bath f 2 bath . These relations are based on the assumption (24) that volume fractions of additives in the bath and in the uid phase of the gel coincide.…”

mentioning

confidence: 99%

See 3 more Smart Citations

The effect of saccharides on equilibrium swelling of thermo-responsive gels

Drozdov

Christiansen

2020

RSC Adv.

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 64%

“…Eqn (19) means that G 2 vanishes when a gel is in the swollen state, and the modulus grows (due to aggregation of hydrophobic segments) with h when the gel is in the collapsed state.…”

Section: Swelling Of Tr Gels In Solutions Of Additivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The effect of saccharides on equilibrium swelling of thermo-responsive gels

Drozdov

Christiansen

2020

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…The area inside the loop is proportional to the energy dissipated in one field cycle swollen sate, thermodynamics of solute transport is coupled with the elasticity and swelling behavior of the polymer chain network. 42 In particular, for magnetic drug delivery, the convective transport plays a dominant role in the processes of magnetically actuated drug release kinetics.…”

Section: Stimuli-responsive Hydrogelsmentioning

confidence: 99%

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Sung

Kim

Abelmann

2020

Bioengineering & Transla Med

View full text Add to dashboard Cite

Soft micro-and nanostructures have been extensively developed for biomedical applications. The main focus has been on multifunctional composite materials that combine the advantages of hydrogels and colloidal particles. Magnetic microgels and nanogels can be realized by hybridizing stimuli-sensitive gels and magnetic nanoparticles. They are of particular interest since they can be controlled in a wide range of biological environments by using magnetic fields. In this review, we elucidate physical principles underlying the design of magnetic microgels and nanogels for biomedical applications. Particularly, this article provides a comprehensive and conceptual overview on the correlative structural design and physical functionality of the magnetic gel systems under the concept of colloidal biodevices. To this end, we begin with an overview of physicochemical mechanisms related to stimuli-responsive hydrogels and transport phenomena and summarize the magnetic properties of inorganic nanoparticles. On the basis of the engineering principles, we categorize and summarize recent advances in magnetic hybrid microgels and nanogels, with emphasis on the biomedical applications of these materials. Potential applications of these hybrid microgels and nanogels in anticancer treatment, protein therapeutics, gene therapy, bioseparation, biocatalysis, and regenerative medicine are highlighted. Finally, current challenges and future opportunities in the design of smart colloidal biodevices are discussed.

show abstract

Nanoparticle Transport Through Polymers and Along Interfaces

Boyle

Maguire

Rose

et al. 2022

Macromolecular Engineering

View full text Add to dashboard Cite

Transport of nanoparticles has received increasing attention for both fundamental interest to test prevailing models as well as practical interest in separations and self‐healing applications. Methods for measuring particle dynamics are briefly reviewed to orient the reader to different methodologies. The transport of nanoparticles through polymer melts, solutions, and cross‐linked networks is described with emphasis on systems where the nanoparticle is on the length scale of the defining structure including the tube size, correlation length, and mesh size, respectively. Because nanoparticles can interact with the different mediums, the interactions between nanoparticles and polymer and the subsequent impacts on dynamics are described. The transport of particles at liquid–solid (polymer brush) interfaces is addressed due to growing interest in applications ranging from understanding dynamics in porous media to the translocation of DNA. Both hard particles and polymer grafted particles (soft particles) are described. The objective of this article is to provide the reader with fundamental descriptions of phenomena while reviewing the current state of understanding. Further directions will leverage advances in inorganic chemistry to prepare monodisperse, functional nanoparticles as well as polymer chemistry to create novel media, such as networks with monodisperse mesh size.

show abstract

The swollen polymer network hypothesis: Quantitative models of hydrogel swelling, stiffness, and solute transport

Cited by 210 publications

References 62 publications

The effect of saccharides on equilibrium swelling of thermo-responsive gels

The effect of saccharides on equilibrium swelling of thermo-responsive gels

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Nanoparticle Transport Through Polymers and Along Interfaces

Contact Info

Product

Resources

About