Journal of Sex Research

1967

DOI: 10.1080/00224496709550516

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The sympathetic‐inhibiting effects of the drug Ismelin on human male eroticism, with a note on Mellaril∗∗

Robert Yankowitz²

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Guanethidine (Ismelin®)5

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10

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1978

1978

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1988

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Cited by 16 publications

(11 citation statements)

References 12 publications

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“…14(1-2) jan-Jun, 1982 BUFFUM reactions (Veterans Administration 1977a; Bauer et a!. 197 3;Bulpitt & Dollery 197 3;Prichard et al 1968;Money & Yankowitz 1967;Seedat & Pillay 1966;Lowther & Turner 1963;Bauer et al 1961). Decreased erections have a reported incidence of four percent to 100% (Bauer eta!.…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 94%

“…Decreased erections have a reported incidence of four percent to 100% (Bauer eta!. 1973;Prichard et al 1968 ;Money & Yankowitz 1967;Vejlsgaard, Christensen & Clausen 1967;Seedat & Pillay 1966;Rosenbloom et al 1963;Schirger 1962), and is probably due to a shunting of blood away from the penis. Failure of ejaculation has been reported in two percent to 100% of the patients, and is due to the blockage of sympathetic enervation for emission (Bauer et al 197 3;Bulpitt & Dollery 197 3;Prichard et a!.…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 95%

“…These sexual side effects h ave been seen in dosages over 25 mg/day (Veterans Administration 1977a;Bauer et al 1973;Prichard eta!. 1968 ;Money & Yankowitz 1967;Seedat & Pillay 1966;Lowther & Turner 1963;Bauer et al 1961).…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 95%

“…Failure of ejaculation has been reported in two percent to 100% of the patients, and is due to the blockage of sympathetic enervation for emission (Bauer et al 197 3;Bulpitt & Dollery 197 3;Prichard et a!. 1968;Money & Yankowitz 1967 ;Vejlsgaard, Christensen & Clausen 1967;Seed at & Pillay 1966 ;Rosenbloom et al 1963;Schriger 1962). Most patients described having had dry sex.…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 95%

“…Its antihypertensive effect is due to inhibition of responses to sympathetic adrenergic nerve activation and to indirect-acting sympathomimetic amines, through its prevention of norepinephrine reuptake into intraneuronal storage granules (Nickerson & Collier 197 5) . Guanethidine has been reported to cause decreased erections, failure of ejaculation (i.e., failure of emission) and decreased libido (Veterans Administration 1977a; Kedia & Markland 197 Sa;Bauer et al 197 3;Bulpitt & Dollery 197 3;Prichard et al 1968 ;Money & Yankowitz 1967;Vejlsgaard, Christensen & Clausen 1967;Seedat & Pillay 1966;Lowther & Turner 196 3;Schirger 1962;Bauer et al 1961). In one study, mildly decreased libido was reported in 29% of the patients (Bauer eta!.…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 97%

See 4 more Smart Citations

Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

¹

1982

Journal of Psychoactive Drugs

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The literature on the sexual side effects of drugs and chemicals has been reviewed. There are many substances which alter the human sociosexual response cycle either negatively, positively or both. Many of the drugs used therapeutically have been reported to have adverse effects on sexuality, and this must be taken into account when these drugs are used clinically. Many substances which are used for recreational purposes (or sometimes abused) also have profound effects on sexual response. Many of these substances are used in such a way that they can correct underlying sexual problems. Treatment of a drug abuser may well prove unsuccessful without consideration of preexistent sociosexual problems and concerns. From the dawn of recorded history, many substances have been used for the purpose of sexual enhancement. Some of these have known success and their reputations have been passed down through the millenia. The chapter has not yet been closed on aphrodisiacs, even though none have survived the rigors of scientific scrutiny. As long as humans place value on optimal sexual functioning, there will be a demand for sex-enhancing drugs. In order for the scientific and medical community to successfully meet these challenges, more effective and relevant study designs will have to be utilized in order to separate fact from fancy. The study of pharmacosexology is in its infancy, and in order for it to grow and contribute to the world body of knowledge, more researchers and clinicians must be trained in both pharmacology and sexology.

“…14(1-2) jan-Jun, 1982 BUFFUM reactions (Veterans Administration 1977a; Bauer et a!. 197 3;Bulpitt & Dollery 197 3;Prichard et al 1968;Money & Yankowitz 1967;Seedat & Pillay 1966;Lowther & Turner 1963;Bauer et al 1961). Decreased erections have a reported incidence of four percent to 100% (Bauer eta!.…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 94%

“…Decreased erections have a reported incidence of four percent to 100% (Bauer eta!. 1973;Prichard et al 1968 ;Money & Yankowitz 1967;Vejlsgaard, Christensen & Clausen 1967;Seedat & Pillay 1966;Rosenbloom et al 1963;Schirger 1962), and is probably due to a shunting of blood away from the penis. Failure of ejaculation has been reported in two percent to 100% of the patients, and is due to the blockage of sympathetic enervation for emission (Bauer et al 197 3;Bulpitt & Dollery 197 3;Prichard et a!.…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 95%

“…These sexual side effects h ave been seen in dosages over 25 mg/day (Veterans Administration 1977a;Bauer et al 1973;Prichard eta!. 1968 ;Money & Yankowitz 1967;Seedat & Pillay 1966;Lowther & Turner 1963;Bauer et al 1961).…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 95%

“…Failure of ejaculation has been reported in two percent to 100% of the patients, and is due to the blockage of sympathetic enervation for emission (Bauer et al 197 3;Bulpitt & Dollery 197 3;Prichard et a!. 1968;Money & Yankowitz 1967 ;Vejlsgaard, Christensen & Clausen 1967;Seed at & Pillay 1966 ;Rosenbloom et al 1963;Schriger 1962). Most patients described having had dry sex.…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 95%

“…Its antihypertensive effect is due to inhibition of responses to sympathetic adrenergic nerve activation and to indirect-acting sympathomimetic amines, through its prevention of norepinephrine reuptake into intraneuronal storage granules (Nickerson & Collier 197 5) . Guanethidine has been reported to cause decreased erections, failure of ejaculation (i.e., failure of emission) and decreased libido (Veterans Administration 1977a; Kedia & Markland 197 Sa;Bauer et al 197 3;Bulpitt & Dollery 197 3;Prichard et al 1968 ;Money & Yankowitz 1967;Vejlsgaard, Christensen & Clausen 1967;Seedat & Pillay 1966;Lowther & Turner 196 3;Schirger 1962;Bauer et al 1961). In one study, mildly decreased libido was reported in 29% of the patients (Bauer eta!.…”

Section: Guanethidine (Ismelin®)mentioning

confidence: 97%

See 3 more Smart Citations

Pharmacosexology: The Effects of Drugs on Sexual Function – A Review

¹

1982

Journal of Psychoactive Drugs

View full text Add to dashboard Cite

The literature on the sexual side effects of drugs and chemicals has been reviewed. There are many substances which alter the human sociosexual response cycle either negatively, positively or both. Many of the drugs used therapeutically have been reported to have adverse effects on sexuality, and this must be taken into account when these drugs are used clinically. Many substances which are used for recreational purposes (or sometimes abused) also have profound effects on sexual response. Many of these substances are used in such a way that they can correct underlying sexual problems. Treatment of a drug abuser may well prove unsuccessful without consideration of preexistent sociosexual problems and concerns. From the dawn of recorded history, many substances have been used for the purpose of sexual enhancement. Some of these have known success and their reputations have been passed down through the millenia. The chapter has not yet been closed on aphrodisiacs, even though none have survived the rigors of scientific scrutiny. As long as humans place value on optimal sexual functioning, there will be a demand for sex-enhancing drugs. In order for the scientific and medical community to successfully meet these challenges, more effective and relevant study designs will have to be utilized in order to separate fact from fancy. The study of pharmacosexology is in its infancy, and in order for it to grow and contribute to the world body of knowledge, more researchers and clinicians must be trained in both pharmacology and sexology.

Erectile Dysfunction Associated with Pharmacological Agents

¹

,

²

,

³

et al. 1985

Diagnosis and Treatment of Erectile Disturbances

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No abstract

Alcohol, Medications, and Other Drugs

¹

1983

Treatment Interventions in Human Sexuality

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No abstract

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