1995
DOI: 10.1016/0960-894x(95)00112-7
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The synthesis and antibacterial activity of 2-carbolinyl-carbapenems: potent anti-MRSA/MRCNS agents

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Cited by 25 publications
(7 citation statements)
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“…L-695,256 ( 22 ), the first member of a new class of 2-arylcarbapenems, possesses high affinity for the PBP2a and is highly active against MRSA and penicillin-resistant pneumococci . A series of 2-carbolinylcarbapenems ( 23 ) was recently reported to be active against MRSA And MRCNS . Other anti-MRSA carbapenems belong to 1-β-methylcarbapenems series.…”
Section: Novel Analogs/novel Compoundsmentioning
confidence: 99%
See 1 more Smart Citation
“…L-695,256 ( 22 ), the first member of a new class of 2-arylcarbapenems, possesses high affinity for the PBP2a and is highly active against MRSA and penicillin-resistant pneumococci . A series of 2-carbolinylcarbapenems ( 23 ) was recently reported to be active against MRSA And MRCNS . Other anti-MRSA carbapenems belong to 1-β-methylcarbapenems series.…”
Section: Novel Analogs/novel Compoundsmentioning
confidence: 99%
“…64 A series of 2-carbolinylcarbapenems (23) was recently reported to be active against MRSA And MRCNS. 65 Other anti-MRSA carbapenems belong to 1-β-methylcarbapenems series. 1-β-Methylcarbapenems having good activity against MRSA include 24, 66 SM-17466 (25), 67 and 26.…”
Section: Novel Analogs/novel Compoundsmentioning
confidence: 99%
“…Naturally occurring β-carboline alkaloids and synthetic analogues containing β-carboline subunit are endowed with diverse pharmacological properties including antimalarial, anti-HIV, antibacterial, antitumor, and anticancer activities . Among these derivatives, the naturally occurring β-carboline alkaloids such as harmicine, fascaplysin, and callophycin A (Figure ) are reported to display antiproliferative effect against many cancer cell lines .…”
Section: Introductionmentioning
confidence: 99%
“…Although they do not have a compound in the clinic, their significant contributions in this area are worth mentioning in this review. Their initial work focused on introduction of lipophilic aryl groups to the C-2 position of the carbapenem ring in order to increase in vitro MRSA potency [101,102]. A cationic substituent was introduced on the C-2 side-chain in order to reduce protein binding and achieve in vivo efficacy.…”
Section: L-786392 (Merck)mentioning
confidence: 99%