The synthesis and characterization of the polyurethanes with antimicrobial properties

Abstract

In this experimental research, thin polyurethane films containing reactive functional groups (hydroxyl and amino groups) were synthesized. The raw materials used in the synthesis are: a hydroxyl component (Elastoflex W5516/115) and an isocyanate component (semiprepolimer type) based on 4,4'- diphenylmethane-diisocyanate (MDI) or toluene-2,4-diisocyanate (TDI). Two different antibiotics were adsorbed on these films: amikacin and ceftazidime which formed physical bonds with the polyurethane matrix. The films were characterized by SEM, DMA and a culture of Escherichia coli and a counting room was used in order to determine the antimicrobial efficiency.

Formulation and Characterization of Antibacterial Hydrogels Based on Polyurethane Microstructures and 1,2,4-Triazole Derivatives

“…[30]. The decrease of cells number is not a linear one because the cellular rests become a nutritive layer for the other cells [14].…”

“…The efficacy against Escherichia coli was evaluated using a protocol described in e-Polymers five years ago [14]: every sample was treated with meat broth containing 0.1 ml of E. coli culture and was thermostated at 37°C. The number of cells was determined using a Thoma counting chamber by counting of the cells from 5 big squares and usage of the following formula:…”

A Temperature and pH Dual‐Sensitive Multifunctional Polyurethane with Bacteria‐Triggered Antibacterial Activity

“…The films were then immersed in deionized water at 4 °C, 37 °C, or 70 °C until reaching water uptake equilibrium. The water uptake capacity of the samples was calculated according to Equation (1).…”

“…By controlling the type and proportion of soft segments (oligomeric polyols) and hard segments (diisocyanates and chain extenders), researchers have used polyurethane to create a diverse range of materials with a wide span of properties and product forms. [1] The microphase separation caused by the soft and DOI: 10.1002/marc.202300453 hard segments may lead to good biocompatibility, [2] which has attracted considerable attention and recognition for use in medical applications, such as artificial blood vessels, [3] catheters, [4] heart valves, [5] and wound dressing. [6] However, bacterial infection, which has caused higher economic burdens and pain to patients, [7,8] is a hidden danger that medical materials must address.…”

Temperature‐ and pH‐sensitive IPNs grafted onto polyurethane by gamma radiation for antimicrobial drug‐eluting insertable devices

“…Polyurethanes can be functionalized at the surface or in the bulk with other molecules/polymers that possess certain functional groups, such as amides, amines, carboxylic acids or epoxy to improve the blood contacting reactions and the resistance to infection, by applying different methods . Condensation with hydroxyl‐ or amino‐bearing monomers has been shown suitable for promoting physical adsorption of antimicrobial agents, such as amikacin and ceftazidime . Derivatization with one or more nitrogen–halogen‐containing molecules, such as N‐halamine, endowed polyurethane surfaces with bactericidal properties, while with quaternary ammonium groups allowed antiviral features .…”