The Synthesis of Some Organic Compounds of Gold

Denko, Charles W.; Anderson, Arthur K.

doi:10.1021/ja01228a058

Cited by 10 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pattern of toxicity of gold compounds in rats has previously been described (Cortell and Richards, 1942 a, b;Denko and Anderson, 1944). These authors noted the development of transient renal damage, mainly tubular, and raised blood urea, followed by recovery despite continued gold injections.…”

Section: Discussionmentioning

confidence: 78%

Influence of gold salts on adjuvant arthritis in the rat.

Jessop¹,

Currey²

1968

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 78%

Influence of gold salts on adjuvant arthritis in the rat.

Jessop¹,

Currey²

1968

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

“…Some gold(I) xanthate derivatives were described previously. 22 Gold cyclohexylxanthate has not been previously published. All (O-alkyl-dithiocarbonato)gold(I) complexes were synthesized by reaction of the corresponding potassium O-alkyl-dithiocarbonates (KS2COR) with potassium tetrachloroaurate(III) (KAuCl4) by the following general procedure.…”

Section: Methodsmentioning

confidence: 99%

“…All (O-alkyl-dithiocarbonato)gold(I) complexes were synthesized by reaction of the corresponding potassium O-alkyl-dithiocarbonates (KS2COR) with potassium tetrachloroaurate(III) (KAuCl4) by the following general procedure. 22 Potassium O-alkyl-dithiocarbonate (3.97 mmol; KS2COR) was dissolved in 4 mL of distilled H2O. KAuCl4 (0.87 mmol) dissolved in 3 mL of distilled H2O was added quickly and with vigorous stirring.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Antitumoral Activity of Non-Platinum Xanthate Complexes

et al. 2005

View full text Add to dashboard Cite

To establish structure-activity relationships, derivatives of bis(O-alkyldithiocarbonato)platinum(II) complexes were analyzed. Eighteen bis(O-alkyldithiocarbonato) metal complexes were synthesized, and their cytotoxic activity on two human cancer cell lines was compared with the corresponding platinum bis(O-alkyldithiocarbonato) complexes and cisplatin. Complexes were synthesized with palladium, gold, nickel, copper, rhodium, and bismuth. Palladium and bismuth complexes were found to display significant cytotoxic activity. Palladium complexes were most active with up to 10-fold lower IC50 values as compared with the corresponding platinum complexes. The other complexes were only poorly active. Palladium, bismuth, and nickel complexes were more active at pH 6.8 than at pH 7.4. This difference in activity was most pronounced with palladium complexes. A pH of 6.8 and lower has been frequently found in solid tumors. Drugs with such pH dependent activity are supposed to have an improved therapeutic index as compared to drugs that are active irrespective of pH.

show abstract

“…Coucouvanis, 1979). The Au(I) xanthates, AuS 2 COR (Denko and Anderson, 1945), and their triphenylphosphine adducts (Kowala and Swan, 1966;Cariati et al, 1979) have been characterized by spectroscopic techniques, however, thus far no structure determination has been reported. The Au(I) xanthates, AuS 2 COR (Denko and Anderson, 1945), and their triphenylphosphine adducts (Kowala and Swan, 1966;Cariati et al, 1979) have been characterized by spectroscopic techniques, however, thus far no structure determination has been reported.…”

Section: Introductionmentioning

confidence: 99%

Triphenylphosphine- (O -methy Idithiocarbonato)gold(I)

Tiekink¹

1985

Zeitschrift Für Kristallographie - Crystalline Materials

View full text Add to dashboard Cite

The crystal structure of the title compound, (C 6 H 5 ) 3 PAuS 2 -COCH3, has been determined at room temperature. Crystals are triclinic, Pi, a = 10.887(2), b = 11.074(2), c = 8.862(1)Â, a = 104.08(1), β = 95.97(1), y = 99.88(2)°, Z = 2,D m = 1.85; D x = 1.865 Mgm" 3 . The structure was refined by a full-matrix least-squares procedure to final R 0.025 for 3112 unique reflections measured on a CAD-4 diffractometer. The gold atom is linearly coordinated by the Ρ atom and a S atom of the monodentate xanthate ligand. The angle subtended at the gold atom is 174.1(1)° and the associated Au-Ρ and Au-S distances are 2.261(1) and 2.310(1)Â respectively. The deviation from ideal linear geometry has been rationalized in terms of a weak intermolecular Au.. .O interaction.

show abstract

The Synthesis of Some Organic Compounds of Gold

Cited by 10 publications

References 0 publications

Influence of gold salts on adjuvant arthritis in the rat.

Influence of gold salts on adjuvant arthritis in the rat.

Antitumoral Activity of Non-Platinum Xanthate Complexes

Triphenylphosphine- (O -methy Idithiocarbonato)gold(I)

Contact Info

Product

Resources

About