The systemic application of diazepam facilitates the reacquisition of a well-balanced vestibular function in a unilateral vestibular re-input model with intracochlear tetrodotoxin infusion using an osmotic pump

Takeno, Kenji; Shimogori, Hiroaki; Takemoto, Tsuyoshi; Tanaka, Kuniyoshi; Mikuriya, Takefumi; Orita, Hiroshi; Yamashita, Hiroshi

doi:10.1016/j.brainres.2006.04.030

Cited by 11 publications

(4 citation statements)

References 41 publications

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“…BZDs enhance the role of GABA in the central nervous system and effective in relieving vertigo and associated anxiety and panic disorders. 27,28 They also cause muscle relaxation, anterograde amnesia and have muscle relaxant property.…”

Section: Pharmacotherapy Of Vertigomentioning

confidence: 99%

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Current Perspectives in the Pharmacotherapy of Vertigo

Singh¹,

Singh²

2012

An International Journal of Otorhinolaryngology Clinics

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Vertigo is a symptom encountered very commonly in clinical practice due to a disorder in the vestibular system. In addition to dizziness it is very often accompanied by nausea and vomiting. Pharmacotherapy plays an important role in the management of vertigo. Vestibular suppressants and drugs to control nausea and vomiting constitute the mainstay of the pharmacotherapy of vertigo. Specific drug therapy can be given in patients where the underlying disease process causing the vertigo has been identified. Despite the availability of many classes of drugs, there are no definitive, universally accepted guidelines for the treatment of vertigo which makes it even more difficult to follow first-, second-and third-line therapies when treating patients. It is difficult to establish guidelines or a generally acceptable consensus in the treatment of vertigo due to the complexity of vertigo and lack of adequate randomized clinical studies.

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Section: Pharmacotherapy Of Vertigomentioning

confidence: 99%

“…27,28 Calcium antagonists: Cinnarizine which features as a antihistaminic above and flunarizine have been used as antivertigo drugs. 29,30 Both these drugs prevent motion sickness and are vestibular depressants since the vestibular hair cells have calcium channels.…”

Section: Pharmacotherapy Of Vertigomentioning

confidence: 99%

Current Perspectives in the Pharmacotherapy of Vertigo

Singh¹,

Singh²

2012

An International Journal of Otorhinolaryngology Clinics

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“…BZDs activate the effect of GABA in central nervous system and so helpful in relieving vertigo along with anxiety and panic disorders. 30 It has also muscle relaxant property and cause anterograde amnesia. The common BZDs used in medical practice are diazepam, lorazepam, clonazepam and alprazolam.…”

Section: Benzodiazepinesmentioning

confidence: 99%

Pharmacotherapy for vertigo: a current perspective

Swain

2020

Int J Otorhinolaryngol Head Neck Surg

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<p>Vertigo is a symptom often encountered in routine clinical practice. Pharmacotherapy plays a vital role for treating the vertigo. Vestibular sedatives and drugs controlling nausea and vomiting constitute the important part of the pharmacotherapy for vertigo. Although there are several drugs available for controlling the vertigo, there are no definitive and universally accepted drugs available for treatment of vertigo. On the basis of the etiology, drugs with specific mechanism of action may be used to control this disabling symptom. Symptomatic treatment is often priority by many clinicians during the treatment of the vertigo. The pharmacological treatment of the vertigo is often decided after correct etiological evaluation of the symptom. Common drugs which are beneficial for treating vertigo are anticholinergics, antihistamines, benzodiazepines, calcium channel blockers and dopamine receptor antagonists. This review article exclusively focuses on pharmacotherapy of vertigo.</p>

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“…11 Based on the available literature, most commonly used therapeutic drugs are presented in Table 2. 1,12,15,[20][21][22][23][24][25][26][27][28][29][30][31] Surgical intervention for vertigo is very rarely required. Specific exceptions to this rule include complications of chronic middle ear disease, neoplasia involving otological structures, and trauma to the middle/inner ear.…”

mentioning

confidence: 99%

Therapeutic interventions in vertigo management

Kameshwaran

Sarda

2017

Int J Otorhinolaryngol Head Neck Surg

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<p>Vertigo is a condition associated with a spectrum of symptoms and ~30% of general population experience vertigo in their life time. In spite of being of high clinical importance, the management of vertigo is quite challenging. Though the literature supports the availability of various therapeutic interventions used in vertigo treatment, their effectiveness depends on accurate diagnosis, appropriate use of intervention, and physician’s awareness of the overlap between vestibular, autonomic, and psychological aspects of vestibular pathology. Unfortunately, several drugs act as tranquilizers and impede the process of vestibular compensation. Betahistine, a histamine analogue, is one of the most commonly used anti-vertigo drugs worldwide and has been supported by many clinical trials. There have been several oral communications in international conferences on the efficacy of using betahistine in several clinical vertiginous syndromes. The current review assesses the use of betahistine 48 mg twice daily for three months as an efficient and well-tolerated treatment for vertigo. Additionally, it highlights the low incidence of side effects even at high doses of betahistine and suggests that it may be considered as the first-line of treatment for vestibular dysfunction.</p>

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The systemic application of diazepam facilitates the reacquisition of a well-balanced vestibular function in a unilateral vestibular re-input model with intracochlear tetrodotoxin infusion using an osmotic pump

Cited by 11 publications

References 41 publications

Current Perspectives in the Pharmacotherapy of Vertigo

Current Perspectives in the Pharmacotherapy of Vertigo

Pharmacotherapy for vertigo: a current perspective

Therapeutic interventions in vertigo management

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