The educational landscape, notably the whole-person movement, continues to evolve, with experts and policymakers from various fronts espousing the integration of information and communication technology in pedagogy, the development of life and work skills, and the nurture of the mind and spirit via project-based instruction. A prior examination of the Media and Information Literacy (MIL) for senior high school in the Philippines, however, showed a tendency to teach knowledge transfer and a lack of emphasis on interpersonal and intrapersonal skills development. This research attempted to measure the manifestations of the development of cognitive, interpersonal, and intrapersonal potentials of respondents using a reinvented and project-based 21CC paradigm in teaching MIL, as well as determine any correlation between respondents' demonstration of these potentials in the implementation of the output-based curriculum with their class performance. A 42-item Likert Scale online self-assessment questionnaire was administered to 138 out of the 150 Grade 11 students from five sections between May 19 and 22, 2019, with items pertaining to assessment, group presentations, publication, visual design, audio production, interview, media fasting, and responsible media use. Analysis of quantitative data was done using inferential statistics. Results showed furtherance of cognitive skills development and strong acquisition in the metacognitive skillsets. Furthermore, the Pearson r test revealed strongly significant correlations for cognitive (r(100) = .307, p < .002), interpersonal (r(100) = .288, p < .003), and intrapersonal competencies (r(100) = .313, p < .001), indicating that the newly designed MIL curriculum can enhance cognitive, interpersonal, and intrapersonal skills.