The Task of Desferrioxamine and Iron in the Immune Interplay between mononuclears and Colon Cancer Cells

Bessler, Hanna; Internationals, Ommega

doi:10.15436/2471-5891.17.1277

Cited by 1 publication

(1 citation statement)

References 28 publications

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“…In the current study, the biosynthetic gene clusters related to production of desferrioxamine B was detected in MUSC 1J T . Even though desferrioxamine has long been used clinically to treat iron toxicity, various studies suggested the potential use of this compound to manage other diseases including osteoporosis 89 , neurodegenerative diseases 90,91 and cancer 92,93 . Nonetheless, the genome potential of MUSC 1J T genome prompts application of advanced techniques like genome editing with CRISPR-Cas9 systems to accentuate its ability in producing these bioactive metabolites.…”

Section: Discussionmentioning

confidence: 99%

Streptomyces monashensis sp. nov., a novel mangrove soil actinobacterium from East Malaysia with antioxidative potential

Law

Ser

Mutalib

et al. 2019

Sci Rep

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A new Streptomyces species discovered from Sarawak mangrove soil is described, with the proposed name – Streptomyces monashensis sp. nov. (strain MUSC 1J T ). Taxonomy status of MUSC 1J T was determined via polyphasic approach. Phylogenetic and chemotaxonomic properties of strain MUSC 1J T were in accordance with those known for genus Streptomyces . Based on phylogenetic analyses, the strains closely related to MUSC 1J T were Streptomyces corchorusii DSM 40340 T (98.7%), Streptomyces olivaceoviridis NBRC 13066 T (98.7%), Streptomyces canarius NBRC 13431 T (98.6%) and Streptomyces coacervatus AS-0823 T (98.4%). Outcomes of DNA–DNA relatedness between strain MUSC 1J T and its closely related type strains covered from 19.7 ± 2.8% to 49.1 ± 4.3%. Strain MUSC 1J T has genome size of 10,254,857 bp with DNA G + C content of 71 mol%. MUSC 1J T extract exhibited strong antioxidative activity up to 83.80 ± 4.80% in the SOD assay, with significant cytotoxic effect against colon cancer cell lines HCT-116 and SW480. Streptomyces monashensis MUSC 1J T (=DSM 103626 T = MCCC 1K03219 T ) could potentially be a producer of novel bioactive metabolites; hence discovery of this new species may be highly significant to the biopharmaceutical industry as it could lead to development of new and useful chemo-preventive drugs.

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