The therapeutic voyage of pyrazole and its analogs: A review

Recent Reports on Pyrazole-Based Bioactive Compounds as Candidate for Anticancer Agents

“…It is caused by miss-regulation or mutation of the cell cycle that regulate genes and proteins. Cancer is a group of various diseases, i.e., lung cancer, cervical cancer, prostate cancer, and breast cancer, and all of them are characterized by an abnormal control of cell growth [19]. Despite many clinically successful anticancer drugs have been developed either natural products or synthetic derivatives of naturally occurring lead compounds, there are still limitations in the treatment of cancer including the effectiveness of drugs and serious side effects [20].…”

The crystal structure of ethyl 1-(4-nitrophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, C13H10F3N3O4

“…Pyrazole derivatives have broad applications in medicinal [3,4] and agricultural chemistry [5,6]. The pharmacological activity of these compounds is very diverse.…”

“…The pharmacological activity of these compounds is very diverse. A number of substituted pyrazoles are reported as anti-inflammatory, analgesic, anti-bacterial and anti-cancer agents [3,4]. It has been found that the presence of a fluoroalkyl substituent on the pyrazole core can significantly increase the lipophilicity and solubility of the compounds and thus improve their biological activity [7][8][9].…”

N-{2-[2-(5-Methyl-1H-pyrazol-3-yl)acetamido]phenyl}benzamide monohydrate

“…Pyrazole derivatives have pharmacologically attractive biological applications (Havrylyuk et al, 2016) and interesting therapeutic properties (Khan et al, 2016). These compounds have been synthesized as target structures by many researchers and have been evaluated for their beneficial bioactivity and for the rational design of a new generation of small molecule drugs (Kü çü kgü zel & Ş enkardeş, 2015).…”