The threat of bioterrorism

Tournier, Jean‐Nicolas; Peyrefitte, Christophe N.; Biot, Fabrice; Mérens, Audrey; Simon, Fabrice

doi:10.1016/s1473-3099(18)30709-6

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…Moreover, there are many other types of diseases where cases occur in a spatially localized point-source outbreak. These include non-communicable infectious diseases, food-based illnesses, environmental hazards (chemical or biological), or even the deliberate release of a biological agent such as anthrax in the context of bioterrorism [ 17 – 22 ].…”

Section: Introductionmentioning

confidence: 99%

Finding disease outbreak locations from human mobility data

Schlosser

Brockmann

2021

EPJ Data Sci.

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Finding the origin location of an infectious disease outbreak quickly is crucial in mitigating its further dissemination. Current methods to identify outbreak locations early on rely on interviewing affected individuals and correlating their movements, which is a manual, time-consuming, and error-prone process. Other methods such as contact tracing, genomic sequencing or theoretical models of epidemic spread offer help, but they are not applicable at the onset of an outbreak as they require highly processed information or established transmission chains. Digital data sources such as mobile phones offer new ways to find outbreak sources in an automated way. Here, we propose a novel method to determine outbreak origins from geolocated movement data of individuals affected by the outbreak. Our algorithm scans movement trajectories for shared locations and identifies the outbreak origin as the most dominant among them. We test the method using various empirical and synthetic datasets, and demonstrate that it is able to single out the true outbreak location with high accuracy, requiring only data of $N=4$ N = 4 individuals. The method can be applied to scenarios with multiple outbreak locations, and is even able to estimate the number of outbreak sources if unknown, while being robust to noise. Our method is the first to offer a reliable, accurate out-of-the-box approach to identify outbreak locations in the initial phase of an outbreak. It can be easily and quickly applied in a crisis situation, improving on previous manual approaches. The method is not only applicable in the context of disease outbreaks, but can be used to find shared locations in movement data in other contexts as well.

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Section: Introductionmentioning

confidence: 99%

Finding disease outbreak locations from human mobility data

Schlosser

Brockmann

2021

EPJ Data Sci.

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“…Avec l'essor concomitant de la biologie moléculaire et du séquençage, la génétique inverse s'est développée pour les virus eucaryotes, à Voir le texte pour le détail des différentes étapes.quelques mois le cauchemar de tous les responsables politiques, économiques, sanitaires et sociaux de la planète. Même si le taux de mortalité intrinsèque du virus n'atteint pas les niveaux des virus classés dans les armes biologiques de guerre[17], et qu'il s'attaque à une frange âgée de la population, il n'y a jamais eu,…”

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Une course contre la montre

Iseni¹,

Tournier

2020

Med Sci (Paris)

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Le SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2), qui a émergé à la fin de l’année 2019 en République populaire de Chine, est responsable d’une crise sanitaire mondiale qui a entraîné le confinement de plus de 3 milliards d’individus et l’arrêt brutal de l’économie planétaire. Dans ce contexte, une course contre la montre est lancée afin de développer, dans les plus brefs délais, un traitement permettant d’enrayer la pandémie. Une étude de l’équipe de Volker Thiel, parue dans le journal Nature, rapporte la mise au point d’une technique de génétique inverse pour le SARS-CoV-2, leur ayant permis de recréer le virus en seulement quelques semaines. Les perspectives de ces travaux sont très intéressantes puisqu’elles permettent d’envisager la manipulation génétique du virus et ainsi le développement d’outils précieux qui seront utiles pour combattre l’infection. Si la technique représente également un saut technologique qui permettra d’améliorer nos connaissances sur le virus, elle porte aussi en elle le germe d’un possible mésusage et la création d’un virus à des fins malveillantes. Les avantages et inconvénients de recréer le SARS-CoV-2 dans cette période de pandémie sont discutés dans cet article.

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Nanotheranostics Approaches in Antimicrobial Drug Resistance

Bueno¹

2019

Nanotheranostics

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The threat of bioterrorism

Cited by 7 publications

References 6 publications

Finding disease outbreak locations from human mobility data

Finding disease outbreak locations from human mobility data

Une course contre la montre

Nanotheranostics Approaches in Antimicrobial Drug Resistance

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