The transcriptional profile of adipose-derived stromal cells (ASC) mirrors the whitening of adipose tissue with age

Scambi, Ilaria; Peroni, Daniele; Nodari, Alice; Merigo, Flavia; Benati, Donatella; Boschi, Federico; Mannucci, Silvia; Andrea, Frontini; Visonà, Silvia Damiana; Sbarbati, Andrea; Krampera, Mauro; Galiè, Mirco

doi:10.1016/j.ejcb.2022.151206

Cited by 9 publications

(6 citation statements)

References 54 publications

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“…Although subcutaneous and visceral WAT supposedly comprised of beige adipocytes were enlarged, UCP1 was poorly detected in young mice and it was not detected in old mice, suggesting that there was a complete loss of thermogenic capacity upon aging. A switch from brown/beige- to white-like adipocytes was observed in FVB mice after 12- months of age ( 128 ). Moreover, the transcriptional profile of adipose-derived stromal cells mirrors these changes both at mRNA and microRNA transcriptional levels through E2F transcription factor 1 (E2F1) and nuclear factor kappa B (NFkβ) ( 128 ).…”

Section: Factors Inducing Bat/beige Adipose Tissue Whitening or Inact...mentioning

confidence: 99%

“…A switch from brown/beige- to white-like adipocytes was observed in FVB mice after 12- months of age ( 128 ). Moreover, the transcriptional profile of adipose-derived stromal cells mirrors these changes both at mRNA and microRNA transcriptional levels through E2F transcription factor 1 (E2F1) and nuclear factor kappa B (NFkβ) ( 128 ).…”

Section: Factors Inducing Bat/beige Adipose Tissue Whitening or Inact...mentioning

confidence: 99%

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An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin

et al. 2023

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Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy expenditure, has been extensively studied as a potential avenue to combat obesity. Although BAT is the opposite of white adipose tissue (WAT) which is responsible for energy storage, BAT shares thermogenic capacity with beige adipose tissue that emerges from WAT depots. This is unsurprising as both BAT and beige adipose tissue display a huge difference from WAT in terms of their secretory profile and physiological role. In obesity, the content of BAT and beige adipose tissue declines as these tissues acquire the WAT characteristics via the process called “whitening”. This process has been rarely explored for its implication in obesity, whether it contributes to or exacerbates obesity. Emerging research has demonstrated that BAT/beige adipose tissue whitening is a sophisticated metabolic complication of obesity that is linked to multiple factors. The current review provides clarification on the influence of various factors such as diet, age, genetics, thermoneutrality, and chemical exposure on BAT/beige adipose tissue whitening. Moreover, the defects and mechanisms that underpin the whitening are described. Notably, the BAT/beige adipose tissue whitening can be marked by the accumulation of large unilocular lipid droplets, mitochondrial degeneration, and collapsed thermogenic capacity, by the virtue of mitochondrial dysfunction, devascularization, autophagy, and inflammation.

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Section: Factors Inducing Bat/beige Adipose Tissue Whitening or Inact...mentioning

confidence: 99%

Section: Factors Inducing Bat/beige Adipose Tissue Whitening or Inact...mentioning

confidence: 99%

An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin

et al. 2023

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“…By comparison, UCP1 protein expression in ingWAT was not detected at any time point by western analysis ( Figure 1f ). However, multilocular UCP1 positive cells in rabbit ingWAT are detected when immunohistochemical analysis was conducted, which is similar to that of the inguinal adipose tissue of young mice [ 22 , 23 ]. The ingWAT has multilocular UCP1 positive cells on day 1 rabbits and these cells essentially disappeared by day 14 ( Figure 1g ).…”

Section: Resultsmentioning

confidence: 99%

Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions

Wan

Long

et al. 2022

Adipocyte

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Interscapular brown adipose tissue (iBAT) of both rabbits and humans exhibits a similar whitening phenomenon under physiological conditions. However, a detailed characterization of iBAT whitening in them is still lacking. Here, we chose rabbits as a model to gain a better understanding of the molecular signature changes during the whitening process of iBAT by transcriptomic analysis of rabbit iBAT at day 1, day 14, 1 month and 4 months after birth. We applied non-invasive MRI imaging to monitor the whitening process and correlated these changes with analysis of morphological, histological and molecular features. Principal component analysis (PCA) of differentially expressed genes delineated three major phases for the whitening process as Brown, Transition and Whitened BAT phases. RNA-sequencing data revealed that whitening of iBAT was an orchestrated process where multiple types of cells and tissues participated in a variety of physiological processes including neovascularization, formation of new nervous networks and immune regulation. Several key metabolic and signalling pathways contributed to whitening of iBAT, and immune cells and immune regulation appeared to play an overarching role.

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“…Nevertheless, a newfound understanding of the cellular and functional remodeling of white adipose tissue (WAT) and brown adipose tissue (BAT) during aging has surfaced in recent years. Adipose plasticity becomes compromised with age, as indicated by heightened visceral adiposity, reduced lipolysis and thermogenesis, and an inability to maintain body temperature during cold stress [ 15 , 16 ]. Current endeavors focus on investigating the potential underlying mechanisms behind age-related alterations in AT, including hypertrophy, adipogenesis, hypoxia, angiogenesis, fibrosis, inflammation, mitochondrial biogenesis, and function [ 17 ] ( Figure 1 ).…”

Section: Morphological Changes In Aged Adipose Tissuementioning

confidence: 99%

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

Jia,

Zhang,

Liu

et al. 2024

Metabolites

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Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis. This review comprehensively summarizes the benefits of regular exercise in addressing the age-related decline in adipose tissue function. Utilizing relevant examples of this approach, we address the possibility of designing therapeutic interventions based on these molecular mechanisms.

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The transcriptional profile of adipose-derived stromal cells (ASC) mirrors the whitening of adipose tissue with age

Cited by 9 publications

References 54 publications

An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin

An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin

Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions

Exercise Alleviates Aging of Adipose Tissue through Adipokine Regulation

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