2021
DOI: 10.1530/raf-20-0076
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The transformative impact of extracellular vesicles on developing sperm

Abstract: Objective To review the role of extracellular vesicles (EVs) released from the male reproductive tract and their impact on developing sperm. We discuss how sperm exiting the seminiferous tubules, although developmentally mature, require further modification. Acquisition of various functions including increased motility, transfer of cargoes and ability to undertake the acrosome reaction are mediated through the interaction between sperm and EVs. Methods A review of the literature identified that EVs are r… Show more

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Cited by 13 publications
(7 citation statements)
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References 124 publications
(175 reference statements)
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“…Exosomes mediate numerous modifications and gains when sperm leave the testes and get into the epididymis [ [26] , [27] , [28] , [29] ]. The cargo of epididymosomes derives from epididymal fluid, caudal and distal have differential cargo loading [ 30 ]. Epididymal caput, corpus and cauda derived exosomal proteins are related to motility (cSrc and MIF), fertilization (SPAM1, GliPr1L1 and Metalloproteases) and acrosome reaction (Liri α3) [ 31 ].…”
Section: The Role Of Exosomes In Gametogenesis and Maturationmentioning
confidence: 99%
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“…Exosomes mediate numerous modifications and gains when sperm leave the testes and get into the epididymis [ [26] , [27] , [28] , [29] ]. The cargo of epididymosomes derives from epididymal fluid, caudal and distal have differential cargo loading [ 30 ]. Epididymal caput, corpus and cauda derived exosomal proteins are related to motility (cSrc and MIF), fertilization (SPAM1, GliPr1L1 and Metalloproteases) and acrosome reaction (Liri α3) [ 31 ].…”
Section: The Role Of Exosomes In Gametogenesis and Maturationmentioning
confidence: 99%
“…Exosomes mediate numerous modifications and gains when sperm leave the testes and enter the epididymis [ [26] , [27] , [28] , [29] ]. In human, bovine and mouse models, the cargo of epididymosomes derives from epididymal fluid, epididymal cauda and caput have differential cargo loading respectively [ 30 ]. In a cat model, epididymal caput, corpus and cauda derived exosomal proteins are related to motility, zona pellucida binding and acrosome reaction, and have been linked to teratospermia [ 31 ].…”
Section: The Role Of Exosomes In Gametogenesis and Maturationmentioning
confidence: 99%
“…Inside the seminal plasma there are extracellular vesicles (EVs) that could be important vehicles of endogenous molecules that, with exogenous factors (chemicals, environmental stressor, ect. ), can modify the constitution and biological function of sperm (Lane et al 2014, Schjenken et al 2020, Rimmer et al 2021.…”
Section: Introductionmentioning
confidence: 99%
“…In the male reproductive tract, EVs have been isolated from testes, epididymis, vas deferens, and accessory glands (Manin et al 1995, Sahlen et al 2010, Stewart et al 2019, Rimmer et al 2021. All these EVs contribute to the complex pool of EVs isolated from seminal plasma that is the body fluid that contains the most abundant amount of EV populations (Höög et al 2015).…”
Section: Introductionmentioning
confidence: 99%
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