The trend of hepatitis B surface antigenimia among teaching hospital patients in Kano

Nwokedi, EE; Emokpae, Mathias Abiodun; Taura, AA; Dutse, AI

doi:10.4314/ajcem.v7i3.7445

Cited by 7 publications

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“…[2,7,23] Seropositivity for HBsAg was high in this study; at 30%, it is comparable to the 25.3% prevalence among children attending all clinics in a previous study from this center. [30] It is also comparable to the 24% reported in a much earlier study from northern Nigeria. [3] However, it was much higher than the 6.5% documented in Pakistan, [4] and zero percent documented by Safaei and Maleknejad [5] in Iran and Anochie et al, [21] in Port Harcourt (Nigeria), although a more recent study from the same center in Port Harcourt has documented a seroprevalence rate of 12.4% among all children attending clinics in the center.…”

Section: Discussionsupporting

confidence: 88%

Nephrotic syndrome among children in Kano: A clinicopathological study

2014

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Section: Discussionsupporting

confidence: 88%

Nephrotic syndrome among children in Kano: A clinicopathological study

2014

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“…[11] A seroprevalence of 23.3% was reported among patients attending all clinics at the Aminu Kano Teaching Hospital (AKTH). [12] When a pregnant woman is infected with HBV, there is a chance she may infect her fetus; 10-20% of women seropositive for HBsAg transmit the virus to their neonates. [13] In women who are seropositive for both HBsAg and HBeAg, mother-to-child transmission is approximately 90%.…”

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confidence: 99%

Sero-prevalence of hepatitis B virus infection and its risk factors among pregnant women attending antenatal clinic at Aminu Kano teaching hospital, Kano, Nigeria

Yakasai

Rabiu

Abubakar

et al. 2012

J Basic Clin Reprod Sci

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Infections due to viral hepatitis are systemic diseases caused by viruses A-E that mostly involve the liver. [1] It is a DNA virus which belongs to the family Hepadnaviridae. The virus was first discovered as 'Australian antigen' and later named hepatitis B surface antigen (HBsAg) in the blood of patients. Hepatitis B e antigen (HBeAg) was discovered later as a marker for patients at a high risk for transmission of the disease. [2] Infection caused by hepatitis B virus (HBV) is a serious public health problem causing about two billion infections worldwide. [3] Transmission is commonly through blood transfusion, blood products, body fluids (urine, semen, sweat, saliva, and tears), use of contaminated needles, vertical transmission (mother to child through infected birth canal), and sexual contact. [1] Neonates born of chronically infected mothers have a 70-90% risk of the infection progressing to a chronic phase. [3] Most countries in Africa have a high HBV endemicity, with the exception of Morocco and Tunisia, which have intermediate endemicity. [4] A prevalence rate of 10% of HBV was found among pregnant women in Hong Kong, [3] 12% in Taiwan, [5] and17.3% in Burkina Faso. [6] A b s t r A c t Background: Pregnant women infected with hepatitis B virus (HBV) can transmit the infection to their fetuses and newborns. Neonates who contract the HBV have about 90% risk of developing chronic HBsAg carriage (HBsAg: hepatitis B surface antigen) and chronic liver disease. Neonatal immunization interrupts this vertical and perinatal transmission. Objectives: To determine the seroprevalence of HBsAg among pregnant women attending the antenatal clinic at Aminu Kano Teaching Hospital (AKTH) and to identify potential risk factors associated with HBV infection. Materials and Methods: A case control study was conducted involving a total of 303 pregnant women attending the antenatal clinic at AKTH and 303 nonpregnant women of childbearing age. Blood sample was collected from each woman and the serum tested for the presence of HBsAg using latex rapid agglutination slide test kit (Cal-Tech Diagnostic Inc., USA) in the laboratory of the hospital. Reactive samples were stored at-20ºC and further confirmed for HBsAg using enzyme-linked immunosorbent assay (ELISA) kits (Bio-Rad, France). HBsAg-positive samples were tested for hepatitis B e antigen (HBeAg) using ELISA kits (Orgenics, Israel). A pretested, structured questionnaire was used for the collection of sociodemographic data and possible risk factors. Results: The prevalence of HBsAg among pregnant women and nonpregnant women were 7.9 and 7.6%, respectively. There was no statistically significant difference in the prevalence of HBsAg in pregnant and nonpregnant women. The presence of HBeAg was statistically significant among both pregnant and nonpregnant women who tested positive for HBsAg. The risk factors associated with HBV infection were blood transfusion, ear piercing, history of an affected sibling with HBV infection, tattooing, and abortion among pregnant women. Conclusion: ...

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“…It is one of the most common infectious diseases globally (8). World health organization (WHO) estimates that HBV results in two million deaths each year worldwide and 230,000 of these occur in Africa (9). The HCV is a single-stranded RNA virus with a propensity for causing chronic and debilitating illness that may result in significant morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B and C Infections Among Pediatric Patients with Sickle Cell Disease at a Tertiary Hospital in Nigeria

Babatola

Olatunya

Faboya

et al. 2020

Arch Pediatr Infect Dis

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Background: The frequent use of blood products for patients with sickle cell disease (SCD) may put them at risk of infecting with hepatitis virus infections, especially if such blood products are not properly screened. Hepatitis B and C infections (HBV and HCV, respectively) may result in cirrhosis and liver cell cancer. Objectives: This study determined the prevalence of HBV and HCV infections among pediatric patients with sickle cell disease in comparison to matched controls at the Ekiti State University Teaching Hospitals (EKSUTH), Ado-Ekiti. Methods: This was a descriptive cross-sectional study that comprised of 116 patients with SCD and their aged and sex-matched controls who referred to the pediatric clinics at EKSUTH. The hemoglobin (Hb) genotypes of the participants were confirmed by Hb electrophoresis and high-performance liquid chromatography (HPLC), Biorad, USA Variant II, using the Beta thalassemia short program. Moreover, HBV and HCV antigens were assessed by the Enzyme-linked Immunosorbent Assay method (Kits were manufactured by Biotech Laboratories USA). Results: The mean ages of the patients with SCD and controls were 8.35 ± 4.50 and 8.92 ± 3.25 years, respectively. The seroprevalence of HBV infection among the children with sickle cell disease and controls was 1% each (P =1.00). The seroprevalence of hepatitis C virus infection was 0% among the two groups. Most (98.3%) of the patients with SCD and controls were fully vaccinated against HBV infection. The two children (100%) that were seropositive for hepatitis B were never vaccinated against HBV infection. Conclusions: The seroprevalence of HBV infection is low among patients with SCD and controls. This may be due to the protective effect of high hepatitis B vaccination rate and high quality of care among our study population.

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The trend of hepatitis B surface antigenimia among teaching hospital patients in Kano

Cited by 7 publications

References 0 publications

Nephrotic syndrome among children in Kano: A clinicopathological study

Nephrotic syndrome among children in Kano: A clinicopathological study

Sero-prevalence of hepatitis B virus infection and its risk factors among pregnant women attending antenatal clinic at Aminu Kano teaching hospital, Kano, Nigeria

Hepatitis B and C Infections Among Pediatric Patients with Sickle Cell Disease at a Tertiary Hospital in Nigeria

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