The trend towards in vivo bioprinting

Wang, Manyi; He, Jiankang; Liu, Yaxiong; Li, Meng; Li, Dichen; Zhang, Jin

doi:10.18063/ijb.2015.01.001

Cited by 82 publications

(67 citation statements)

References 62 publications

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“…Therefore, tests should be carried out on cells or recipient tissue for in situ and in vivo bioprinting. The fine printing resolution of LAB also means a slow printing speed which may not be suitable in some cases where rapid fabrication is required because of dehydration …”

Section: D Bioprinting Techniquesmentioning

confidence: 99%

“… Printability: current 3D bioprinting systems generally have a limitation over the choice of materials because of printability, as the use of nozzles and/or energy to expel the bioink with cells limits the viscosity and surface tension . To keep viscosity low during the bioprinting process and to ensure structural integrity after, various crosslinking methods, such as polymer crosslinking, photo‐crosslinking, and thermal crosslinking, are used Biocompatibility: Bioink should not cause inflammatory or immune response.…”

Section: Bioink In 3d Cell‐bioprintingmentioning

confidence: 99%

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3D bioprinting and itsin vivoapplications

et al. 2017

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The purpose of 3D bioprinting technology is to design and create functional 3D tissues or organs in situ for in vivo applications. 3D cell-printing, or additive biomanufacturing, allows the selection of biomaterials and cells (bioink), and the fabrication of cell-laden structures in high resolution. 3D cell-printed structures have also been used for applications such as research models, drug delivery and discovery, and toxicology. Recently, numerous attempts have been made to fabricate tissues and organs by using various 3D printing techniques. However, challenges such as vascularization are yet to be solved. This article reviews the most commonly used 3D cell-printing techniques with their advantages and drawbacks. Furthermore, up-to-date achievements of 3D bioprinting in in vivo applications are introduced, and prospects for the future of 3D cell-printing technology are discussed.

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Section: D Bioprinting Techniquesmentioning

confidence: 99%

Section: Bioink In 3d Cell‐bioprintingmentioning

confidence: 99%

3D bioprinting and itsin vivoapplications

et al. 2017

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“…These characteristics can provide an appropriate environment for cells and play an important role as a physical substrate for cell attachment, proliferation, and differentiation, as well as integration to the host tissue in order to regenerate the defect [4,5,6]. Although some new methods using shape memory materials, such as bioprinting and 4D printing, are under development [7,8,9,10], they are very much at infancy and less mature than scaffold technology.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Hydrophilicity and Cell Attachment of 3D Printed PCL/Graphene Scaffolds for Bone Tissue Engineering

et al. 2016

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Scaffolds are physical substrates for cell attachment, proliferation, and differentiation, ultimately leading to the regeneration of tissues. They must be designed according to specific biomechanical requirements, i.e., certain standards in terms of mechanical properties, surface characteristics, porosity, degradability, and biocompatibility. The optimal design of a scaffold for a specific tissue strongly depends on both materials and manufacturing processes, as well as surface treatment. Polymeric scaffolds reinforced with electro-active particles could play a key role in tissue engineering by modulating cell proliferation and differentiation. This paper investigates the use of an extrusion-based additive manufacturing system to produce poly(ε-caprolactone) (PCL)/pristine graphene scaffolds for bone tissue applications and the influence of chemical surface modification on their biological behaviour. Scaffolds with the same architecture but different concentrations of pristine graphene were evaluated from surface property and biological points of view. Results show that the addition of pristine graphene had a positive impact on cell viability and proliferation, and that surface modification leads to improved cell response.

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“…In vivo bioprinting is another emerging and promising technology that may bring improvements in the field of regenerative medicine. In vivo bioprinting is thought to be an alternative to the existing in vitro bioprinting methods [115,116] . In vivo bioprinting technology is a medical intervention to directly print new tissue constructs at the defect site.…”

Section: Emerging Strategies In Bioprintingmentioning

confidence: 99%

3D bioprinting technology for regenerative medicine applications

Sundaramurthi¹,

Rauf²,

Hauser³

2016

IJB

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Alternative strategies that overcome existing organ transplantation methods are of increasing importance because of ongoing demands and lack of adequate organ donors. Recent improvements in tissue engineering techniques offer improved solutions to this problem and will influence engineering and medicinal applications. Tissue engineering employs the synergy of cells, growth factors and scaffolds besides others with the aim to mimic the native extracellular matrix for tissue regeneration. Three-dimensional (3D) bioprinting has been explored to create organs for transplantation, medical implants, prosthetics, in vitro models and 3D tissue models for drug testing. In addition, it is emerging as a powerful technology to provide patients with severe disease conditions with personalized treatments. Challenges in tissue engineering include the development of 3D scaffolds that closely resemble native tissues. In this review, existing printing methods such as extrusion-based, robotic dispensing, cellular inkjet, laser-assisted printing and integrated tissue organ printing (ITOP) are examined. Also, natural and synthetic polymers and their blends as well as peptides that are exploited as bioinks are discussed with emphasis on regenerative medicine applications. Furthermore, applications of 3D bioprinting in regenerative medicine, evolving strategies and future perspectives are summarized.

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The trend towards in vivo bioprinting

Cited by 82 publications

References 62 publications

3D bioprinting and itsin vivoapplications

3D bioprinting and itsin vivoapplications

Enhancing the Hydrophilicity and Cell Attachment of 3D Printed PCL/Graphene Scaffolds for Bone Tissue Engineering

3D bioprinting technology for regenerative medicine applications

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