The use of a restricted access volatile supramolecular solvent for the LC/MS-MS assay of bisphenol A in urine with a significant reduction of phospholipid-based matrix effects

Salatti-Dorado, José Ángel; Caballero-Casero, Noelia; Sicilia, María Dolores; Lunar, María Loreto; Rubio, Soledad

doi:10.1016/j.aca.2016.11.026

Cited by 65 publications

(43 citation statements)

References 31 publications

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“…Recently, a new and effective approach to removing both proteins and phospholipids was proposed by Salatti-Dorado et al [171]. It is based on the dual precipitation of both species by using restricted access, volatile supramolecular solvents (RAM-VOL-SUPRAS), nanostructured liquids produced by colloidal solution of amphiphiles by spontaneous processes of self-assembly and coacervation.…”

Section: Removal Of Proteinsmentioning

confidence: 99%

Compensate for or Minimize Matrix Effects? Strategies for Overcoming Matrix Effects in Liquid Chromatography-Mass Spectrometry Technique: A Tutorial Review

et al. 2020

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In recent decades, mass spectrometry techniques, particularly when combined with separation methods such as high-performance liquid chromatography, have become increasingly important in pharmaceutical, bio-analytical, environmental, and food science applications because they afford high selectivity and sensitivity. However, mass spectrometry has limitations due to the matrix effects (ME), which can be particularly marked in complex mixes, when the analyte co-elutes together with other molecules, altering analysis results quantitatively. This may be detrimental during method validation, negatively affecting reproducibility, linearity, selectivity, accuracy, and sensitivity. Starting from literature and own experience, this review intends to provide a simple guideline for selecting the best operative conditions to overcome matrix effects in LC-MS techniques, to obtain the best result in the shortest time. The proposed methodology can be of benefit in different sectors, such as pharmaceutical, bio-analytical, environmental, and food sciences. Depending on the required sensitivity, analysts may minimize or compensate for ME. When sensitivity is crucial, analysis must try to minimize ME by adjusting MS parameters, chromatographic conditions, or optimizing clean-up. On the contrary, to compensate for ME analysts should have recourse to calibration approaches depending on the availability of blank matrix. When blank matrices are available, calibration can occur through isotope labeled internal standards and matrix matched calibration standards; conversely, when blank matrices are not available, calibration can be performed through isotope labeled internal standards, background subtraction, or surrogate matrices. In any case, an adjusting of MS parameters, chromatographic conditions, or a clean-up are necessary.

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Section: Removal Of Proteinsmentioning

confidence: 99%

Compensate for or Minimize Matrix Effects? Strategies for Overcoming Matrix Effects in Liquid Chromatography-Mass Spectrometry Technique: A Tutorial Review

et al. 2020

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“…This characteristic is due to the presence of supramolecular aggregates, promoting a solvent with different degrees of polarity [77][78][79]. Supramolecular solvents have already been used in the determination of several classes of compounds such as parabens, pesticides, polycyclic aromatic hydrocarbons and bisphenols [80][81][82][83].…”

Section: Supramolecular Solvent (Supras) As Extraction Phasementioning

confidence: 99%

Alternative Green Extraction Phases Applied to Microextraction Techniques for Organic Compound Determination

et al. 2019

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The use of green extraction phases has gained much attention in different fields of study, including in sample preparation for the determination of organic compounds by chromatography techniques. Green extraction phases are considered as an alternative to conventional phases due to several advantages such as non-toxicity, biodegradability, low cost and ease of preparation. In addition, the use of greener extraction phases reinforces the environmentally-friendly features of microextraction techniques. Thus, this work presents a review about new materials that have been used in extraction phases applied to liquid and sorbent-based microextractions of organic compounds in different matrices.

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“…As the most widely used SUPRASs, water-insoluble reverse micelles are aggregated by mixing alkyl alcohols or alkyl acids with tetrahydrofuran (THF) and water ( Accioni et al, 2020 ; Yonny et al, 2020 ; Caleb and Alshana, 2021 ). The SUPRASs can extract analytes from aqueous samples effectively ( Jinlei et al, 2021 ) and are particularly suitable for complex samples, such as biofluids with high extraction yields ( Salatti-Dorado et al, 2017 ; Accioni et al, 2020 ; Lian et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Synergistic Combination of Facile Thiol-Maleimide Derivatization and Supramolecular Solvent-Based Microextraction for UHPLC–HRMS Analysis of Glutathione in Biofluids

et al. 2021

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Glutathione (GSH) is the most abundant non-protein thiol in biofluids, enabling diverse physiological functions. Among the proposed methods for GSH detection, ultra-high-performance liquid chromatography (UHPLC) coupled with high-resolution mass spectrometry (HRMS) has the advantages of high sensitivity and efficiency. In this study, a novel analytical method was developed for the determination of GSH using supramolecular solvent (SUPRAS)-based dispersive liquid–liquid microextraction (DLLME) and UHPLC–HRMS. N-Laurylmaleimide was dissolved in tetrahydrofuran, which served three functions: 1) precipitate the proteins present in the biofluid sample, 2) provide a reaction environment for derivatization, and 3) enable the use of SUPRAS as the dispersing agent. Critical parameters were optimized based on single factor testing and response surface methodology. The established method was validated in terms of linearity, accuracy, precision, and successful quantitative analysis of GSH in saliva, urine, and plasma samples. Experimental results showed that SUPRAS as an extraction solvent was particularly suitable for the extraction of GSH from complex matrices. The current study provides a useful tool for accurate measurements of GSH concentrations, which could potentially be used for clinical diagnostics.

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The use of a restricted access volatile supramolecular solvent for the LC/MS-MS assay of bisphenol A in urine with a significant reduction of phospholipid-based matrix effects

Cited by 65 publications

References 31 publications

Compensate for or Minimize Matrix Effects? Strategies for Overcoming Matrix Effects in Liquid Chromatography-Mass Spectrometry Technique: A Tutorial Review

Compensate for or Minimize Matrix Effects? Strategies for Overcoming Matrix Effects in Liquid Chromatography-Mass Spectrometry Technique: A Tutorial Review

Alternative Green Extraction Phases Applied to Microextraction Techniques for Organic Compound Determination

Synergistic Combination of Facile Thiol-Maleimide Derivatization and Supramolecular Solvent-Based Microextraction for UHPLC–HRMS Analysis of Glutathione in Biofluids

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