The use of ammonium hydroxide as an additive in supercritical fluid chromatography for achiral and chiral separations and purifications of small, basic medicinal molecules

Hamman, Chris; Schmidt, Donald E.; Wong, Mengling; Hayes, M.

doi:10.1016/j.chroma.2011.08.064

Cited by 78 publications

(28 citation statements)

References 40 publications

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“…Trifluoracetic acid is the most widely used acidic additive, while diethylamine and triethylamine are commonly used to improve peak shapes of basic analytes [144]. There is also a recent trend toward the use of volatile additives or salts, including formic acid, ammonium hydroxide, ammonium acetate or ammonium formate [145]. These additives are MS-friendly and this detection mode can be useful to differentiate between the enantiomers of interest and other achiral impurities that may be difficult to separate on a CSP [146].…”

Section: Application Of Chiral Sfc In Pharmaceutical Analysismentioning

confidence: 99%

Supercritical fluid chromatography in pharmaceutical analysis

Desfontaine

Guillarme

Francotte

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

208

102

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Section: Application Of Chiral Sfc In Pharmaceutical Analysismentioning

confidence: 99%

Supercritical fluid chromatography in pharmaceutical analysis

Desfontaine

Guillarme

Francotte

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

208

102

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“…[20][21][22][23][24] This indicates that SFC can separate compounds that are difficult to separate by GC and LC. The most important feature is that SFC is environmentally friendly because SFC uses CO 2 and the total amount of harmful organic solvent consumed by the analysis is lower than for LC.…”

Section: Introductionmentioning

confidence: 96%

Differentiation of ring‐substituted regioisomers of amphetamine and methamphetamine by supercritical fluid chromatography

Segawa

Iwata

Yamamuro

et al. 2016

Drug Testing and Analysis

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Chromatographic differentiation of the ring-substituted regioisomers of amphetamine (AMP) and methamphetamine (MA) was performed by supercritical fluid chromatography (SFC). The behaviour of the retention against the changes of column temperature and co-solvent proportion was studied. The obtained information facilitated the optimization of the each regioisomer. As a result, 2-, 3-, and 4-ring-substituted analogues of AMP and MA with methyl, methoxy, fluoro, chloro, and bromo groups were separated, generally within 6 min. In addition, we found that the separation pattern of the examined regioisomers was classified into two, which depended on the electron donating/withdrawing effect of the substituent. Our results indicate that SFC could be used in forensic drug analysis for fast, reliable identification of structurally similar drugs of abuse. Copyright © 2016 John Wiley & Sons, Ltd.

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“…improving the peak shapes of basic drugs, by disrupting the interactions between silanols and basic solutes under SFC conditions [6,51,56]. Therefore, the use of a relatively strong base will likely modify the surface chemistry of the silica, which usually results in improved peak shapes.…”

Section: IIImentioning

confidence: 97%