The Use of Anti-IgE Therapy Beyond Allergic Asthma

Assessment of the Mechanistic Role of Cinnarizine in Modulating Experimentally-Induced Bronchial Asthma in Rats

“…Cytokines, particularly TNF-α, are involved in the initiation and progression of airway inflammation [38,39], with IL-5 particularly reported to have a central role in the initiation of eosinophilic airway inflammation [40], strongly agreeing with our results (table 2). IgE plays a key role in the pathogenesis of extrinsic asthma, as in our model (table 3), through stimulating mast cell degranulation [41]. We also showed that OVA-induced bronchial asthma was associated with oxidative and nitrosative stress (table 4), which was also supported by the results of previous investigators [42,43].…”

Role of Regulatory T cells in Airway Inflammation in Asthma

“…ICS as anti-inflammatory agents are the first choice for management of asthma, but they are just controllers. Curing asthma is still difficult, although anti-IgE and anti-IL-5 therapies have shown results in severe asthma that are as good as other anti-allergic inflammatory agents [47][48][49]. Development of new treatment strategies utilizing Tregs could be useful in attenuating allergic reactions and achieving a cure for asthma.…”

New insights into basophil heterogeneity

“…Strikingly, elevated esophageal TSLP expression levels correlate with increased numbers of infiltrating basophils in the biopsy during active disease in comparison to inactive disease periods [90]. Although EoE is often associated with elevated IgE levels [115,116], omalizumab treatment appears to have limited efficacy in the induction of EoE remission with regard to both histologic features of tissue eosinophil infiltration and clinical disease activity [87,117,118]. One possible explanation could be that the TSLP-basophil axis is particularly potent in the setting of EoE, such that IgE-independent processes drive disease pathogenesis.…”