The use of benzedrine and dexedrine sulfatein the treatment of epilepsy

Livingston, Samuel; Kajdi, Laslo; Bridge, Edward M.

doi:10.1016/s0022-3476(48)80169-1

Cited by 42 publications

(9 citation statements)

References 6 publications

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“…AMPH has been reported to prolong electrically kindled seizures (Babington and Wedeking, 1973) and increase severity of PTZ-induced seizures (Turner and Spencer, 1968) in rats. Alternatively, AMPH has been reported to have anticonvulsant activity in controlling petit ma1 epilepsy (Livingston et al, 1948) as well as to have activity in the flash-evoked afterdischarge rat model of petit ma1 epilepsy (King and Burnham, 1980). The present experiment was carried out to verify the phenomenon and to determine the contribution of repeated AMPH treatment.…”

mentioning

confidence: 76%

A Kindling‐like Effect Induced by Repeated Exposure to Heated Water in Rats

Klauenberg

Sparber

1984

Epilepsia

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Hyperthermia was induced in mature rats by immersing them in 20 cm of 45 degrees C water for 4 min. Rats were made hyperthermic once every 4 days for six exposures. A significant number had at least one convulsion by the third exposure. During the seventh exposure, 2 weeks after the sixth exposure, twice as many rats experienced convulsions. Two weeks later, four rats that had convulsed following exposure to heated water at an earlier time convulsed on exposure to a strobe light flashing at 25 Hz. The percentage of rats having experienced at least one convulsion increased dramatically when tested 2 and then an additional 3 months later. Spontaneous (handling-induced) convulsions also occurred in a few rats that had been exposed to heated water previously. The data indicate that repeated exposure to this type of hyperthermia can result in an increase in convulsive susceptibility in mature rats and may be a useful, noninvasive model for studying kindling, febrile convulsions, and epilepsy in rodents.

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confidence: 76%

A Kindling‐like Effect Induced by Repeated Exposure to Heated Water in Rats

Klauenberg

Sparber

1984

Epilepsia

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“…Similar symptoms in patients with dementia, closed head injury, attention-deficit disorder (ADD), AIDS, cerebral infarction, and metastatic disease have been successfully treated with neurostimulants such as methylphenidate (MPH) (1)(2)(3)(4)(5). In fact, neurostimulants such as d-amphetamines have been proven effective in the treatment of seizures (6,7).…”

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confidence: 99%

An Evaluation of the Effects of Methylphenidate on Outcomes in Adult Epilepsy Patients

Moore

McAuley

Long

et al. 2002

Epilepsy & Behavior

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“…Dopamine is an endogenous neuromodulator in cortical circuits and in the basal ganglia, and is known to be important for normal brain function. As early as the 1940s the role played by dopamine in the pathophysiology of epilepsy was recognized (Strauss, 1944; Livingston et al, 1948). Traditionally, dopamine has been regarded as an anticonvulsant; clinical and experimental evidence, however, clearly indicates that this is an oversimplification (Starr, 1996).…”

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confidence: 99%

Alteration of dopamine D2/D3 receptor binding in patients with juvenile myoclonic epilepsy

Landvogt¹,

Buchholz²,

Bernedo

et al. 2010

Epilepsia

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SUMMARYPurpose: To quantify extrastriatal and striatal D2/D3 receptor binding in patients with juvenile myoclonic epilepsy (JME) using the high-affinity dopamine D2/D3 receptor positron emission tomography (PET) ligand 18 F-Fallypride ([ 18 F]FP). Methods: Twelve patients with JME and 21 age-matched control subjects were studied. Dynamic images (180 min) were acquired after injection of [18 F]FP. Patients had been seizure-free of all seizure types for at least 10 days before scanning. Parametric images of binding potential (BP) were created using the simplified reference tissue model. The images were stereotactically normalized using a ligand-specific template. We performed a voxelbased analysis with statistical parametric mapping (SPM2). Region of interest (ROI) analysis was done comparing the BP of the thalamus, caudate nucleus, anterior (ventral) and posterior (dorsal) putamen, ventral striatum, and temporal lobe.Results: Compared to controls, patients with JME showed a significant decrease in [18 F]FP BP (SPM analysis corr. p < 0.001 at cluster level) restricted to the bilateral posterior putamen. There was no significant alteration of [18 F]FP binding in other brains regions. ROI analysis revealed a significant (p < 0.05) decrease of [ 18 F]FP BP in the left (mean )14.8%) and right (mean )16.9%) posterior putamen, but not in the anterior putamen, caudate, ventral striatum, thalamus, or temporal lobe. Discussion: Patients with JME showed a reduction in D2/3 receptor binding restricted to the bilateral posterior putamen, suggesting a specific alteration of the dopaminergic system. Whether these changes can be regarded as merely functional or whether they relate to the pathophysiology of juvenile myoclonic epilepsy still remains unclear.

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The use of benzedrine and dexedrine sulfatein the treatment of epilepsy

Cited by 42 publications

References 6 publications

A Kindling‐like Effect Induced by Repeated Exposure to Heated Water in Rats

A Kindling‐like Effect Induced by Repeated Exposure to Heated Water in Rats

An Evaluation of the Effects of Methylphenidate on Outcomes in Adult Epilepsy Patients

Alteration of dopamine D2/D3 receptor binding in patients with juvenile myoclonic epilepsy

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