2009
DOI: 10.1111/igc.0b013e31819bcff8
|View full text |Cite
|
Sign up to set email alerts
|

The Use of Cisplatin to Treat Advanced-Stage Cervical Cancer During Pregnancy Allows Fetal Development and Prevents Cancer Progression: Report of a Case and Review of the Literature

Abstract: Neoadjuvant cisplatin chemotherapy can be used in stage IIB cervical carcinoma during pregnancy to allow fetal development and prevent disease progression before delivery.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
39
0
1

Year Published

2010
2010
2022
2022

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 43 publications
(40 citation statements)
references
References 17 publications
0
39
0
1
Order By: Relevance
“…In his review, Hunter et al [5] summarize approximately 100 patients with treatment delay between 2 and 30 weeks and could find equal oncologic outcome compared with non-pregnant women with comparable stage of cervical cancer. In our study, we used neoadjuvant chemotherapy to reach fetal maturity and prevent cancer progression which was followed by radical hysterectomy ± chemoradiation [16,17,18,21,23]. The rationale for our decision to perform elective delivery between the 32nd and 35th week of gestation was based on a consensual multidisciplinary decision which took into account the probability of fetal maturity and the lowest possible cumulative cisplatin dose.…”
Section: Discussionmentioning
confidence: 99%
“…In his review, Hunter et al [5] summarize approximately 100 patients with treatment delay between 2 and 30 weeks and could find equal oncologic outcome compared with non-pregnant women with comparable stage of cervical cancer. In our study, we used neoadjuvant chemotherapy to reach fetal maturity and prevent cancer progression which was followed by radical hysterectomy ± chemoradiation [16,17,18,21,23]. The rationale for our decision to perform elective delivery between the 32nd and 35th week of gestation was based on a consensual multidisciplinary decision which took into account the probability of fetal maturity and the lowest possible cumulative cisplatin dose.…”
Section: Discussionmentioning
confidence: 99%
“…Although there are accumulating data in the literature concerning the administration of cisplatinum and carboplatinum during pregnancy, the safety of these molecules for the fetus remains uncertain. 2,[15][16][17] On the one hand, pregnancy is associated with physiological changes in plasma volume, placental passage, and hepatic and renal metabolism. These particular alterations may significantly affect pharmacokinetics of chemotherapy drugs.…”
mentioning
confidence: 99%
“…Крайне ма-лое число таких наблюдений не позволяет сделать одно-значный вывод о безопасности тактики, направленной на сохранение беременности, особенно при выявлении опухоли в I триместре. Тем не менее индивидуальный подход с учетом мнения пациентки в отношении воз-можности сохранения беременности при ГО необходим, поскольку прогноз для большинства остается благопри-ятным и доказана безопасность применения ряда цито-статиков, в том числе цисплатина в поздние сроки бере-менности [19].…”
Section: Discussionunclassified