The Use of Cryosurgery for Breast Cancer

Ablin, Richard J.

doi:10.1001/archsurg.133.1.106

Cited by 16 publications

(5 citation statements)

References 2 publications

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“…35 In the literature there are very few data about this technique, some of them with the use of an ex vivo, animal model, and US-guided procedure. [36][37][38][39] Morin et al 40 carried out a study to assess the feasibility, safety, and efficacy of MRI-guided cryosurgery in 25 breast cancer patients, using a 0.5T open-configuration MR system. Cryosurgery was followed by mastectomy after 4 weeks, and no serious complications were reported.…”

Section: Rfamentioning

confidence: 99%

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MRI‐guided treatment in the breast

Pediconi

Marzocca

Marincola

et al. 2018

Magnetic Resonance Imaging

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In the last decades, an increasing interest has developed towards non‐invasive breast lesion treatments, which offer advantages such as the lack of surgery‐related complications, better cosmetic outcomes, and less psychological distress. In addition, these treatments could be an option for patients with poor health who are not candidates for surgery. Non‐surgical ablation can be performed under magnetic resonance (MR) or ultrasound (US) guidance. US is cheaper and easily available, while contrast‐enhanced MR is more accurate, ensuring better safety and efficacy for the patient. Overall results of studies about MRI‐guided tumor ablation reported complete ablation rates ranging between 20% and 100%. High‐intensity focused ultrasound (HIFU or FUS) is the most studied ablative technique and it is already established as a valid technique for ablation of benign and malignant tumors in various organs. Ultrasound‐guided FUS is very useful for young patients who refuse surgery or with multiple nodules; however, MR‐guided FUS is more sensitive and allows a better evaluation of thermal accumulation within the ablated tissue or the adjacent structures. Most MR‐guided FUS studies used a dedicated high‐field MR scanner and complete tumor ablation was reported in 17–90% of cases. Other techniques using thermal tissue destruction are radiofrequency ablation (RFA) and laser interstitial thermal therapy (LITT). Only a few studies assessed the efficacy of these treatments, all were performed with open MR devices. RFA showed complete tumor ablation in 30–96% of patients, while LITT in 10–71%, but all the studies had a small number of patients. Cryoablation obtains tissue ablation by a rapid decrease of temperature, with a complete tumor removal reported in 18–52% of cases with MR guidance. No serious complications were reported with these techniques. Currently, breast conservative surgery replaced radical surgery when possible. Therefore, future research should focus on these treatments to shift towards an even less invasive approach to breast neoplasms. Level of Evidence: 5 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2018;48:1479–1488

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Section: Rfamentioning

confidence: 99%

“…In the literature there are very few data about this technique, some of them with the use of an ex vivo, animal model, and US‐guided procedure …”

Section: Cryoablationmentioning

confidence: 99%

MRI‐guided treatment in the breast

Pediconi

Marzocca

Marincola

et al. 2018

Magnetic Resonance Imaging

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“…Breast cancer cryoablation is a minimally invasive outpatient procedure that achieves treatment objectives without significant complications and may be performed in selected patients for palliative and locoregional disease control. Although there is a significant current interest in breast cancer cryoablation for curative intent with the elimination of surgery, palliative breast cryoablation has had a longer history of clinical application for the treatment of recurrent and advanced breast cancer, including multicentric as well as breast cancer with regional nodal or distant metastatic disease 3–10. However, cryoablation of TNBC has been rarely reported,7 11 and there has been no report of multiple breast cryoablation treatments of multicentric TNBC, with pretreatment objectives of breast or nipple pain control and prevention of skin or nipple erosion caused by tumour growth.…”

Section: Discussionmentioning

confidence: 99%

“…There was a resurgence of interest in breast cryoablation after the 2021 publication of the interim results of the prospective, multicenter ICE3 (Cryoablation of Low Risk Small Breast Cancer) trial (NCT02200705), which showed a success rate similar to that of breast-conserving surgery for curative-intent cryoablation of unifocal, ultrasound-visible, 1.5 cm or smaller, low-grade to intermediate-grade, hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer 1 2. However, breast cryoablation has been performed since the 1960s for palliative treatment of breast tumours in patients with other known tumour foci within the body with the goal of complete or partial ablation of the breast malignancy to achieve symptom relief or tumour volume reduction, demonstrating clinical efficacy and improvement of symptoms 3–9…”

Section: Introductionmentioning

confidence: 99%

Breast cryoablation for the palliative treatment of indolent subtype of multicentric triple-negative breast cancer

Huang,

Lane,

Bomar

et al. 2024

BMJ Case Rep

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Breast cryoablation for palliative and curative treatment of breast cancer has been performed for decades. Although there is a recent resurgence of interest in breast cryoablation with curative intent for unifocal, hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer, this report highlights the essential role that cryoablation can play in the palliative treatment of multicentric oestrogen and progesterone receptor-negative and human epidermal growth factor receptor 2-negative (triple-negative) breast cancer, meeting the select pretreatment objectives such as breast or nipple pain relief and prevention of tumour erosion through the skin or nipple in patients who have failed or cannot tolerate the standard of care treatment.

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“…Ablin [1998] further reported the experience of breast cryoablation in the same year. After this, there are several specialists, such as Pfleiderer (Germany) [2002], Kaufman (USA) [2004], Sabel (USA) [2005], and Littrup (USA) [2005], who showed that percutaneous cryoablation is a feasible and promising treatment protocol.…”

Section: Cryosurgery For Breast Cancermentioning

confidence: 99%

History of Cryosurgery

Xu¹

2012

Modern Cryosurgery for Cancer

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Cryosurgery is an old as well as new technique, and has gone through a long-term process of development. The history of "modern" cryosurgery is relatively short and is closely intertwined with developments in low-temperature physics, engineering, and instrumentation that were made during the last century.• The cryosurgical probes developed in the 1960s allow precise application of cryosurgical treatment deep in the body. This unique ability makes cryosurgery very promising and has resulted in the expansion of the method during this era. Cryosurgery had mainly been applied to uterine tumors and neurologic, orthopedic, and skin diseases. • From the end of the 20th century, the development of imaging techniques and new freezing equipment has culminated in the creation of modern cryosurgery. The liquid nitrogen operative system and the argon-helium surgical system represent two important stages of modern cryosurgery. • Now cryosurgery has been successfully used for treatment of a variety of tumors, which include benign and malignant neoplasms of the prostate, lung, liver, pancreas, kidney, breast, uterus, ovary, bone, and soft tissue.

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The Use of Cryosurgery for Breast Cancer

Cited by 16 publications

References 2 publications

MRI‐guided treatment in the breast

MRI‐guided treatment in the breast

Breast cryoablation for the palliative treatment of indolent subtype of multicentric triple-negative breast cancer

History of Cryosurgery

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