The use of genetic markers in predicting of oral lichen planus development and recurrence

Akmalova, Guzel'; Чуйкин, С. В.; Chuykin, Sergey; Ронь, Г. И.; Чернышева, Н.; Chernyshova, Nina; Галимова, Е. С.; Гилязова, И. Р.; Gilyazova, I. R.; Хуснутдинова, Э К; Хуснутдинова, Э. К.

doi:10.18481/2077-7566-2016-12-1-62-69

Cited by 6 publications

(1 citation statement)

References 1 publication

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“…В литературе обсуждаются различные концепции патогенеза КПЛ, среди которых ведущими являются иммуноаллерги-ческая, вирусная, наследственная и мембранодеструктивная [2,3,5,9]. Кроме того, представлены также отечественные работы по изучению генетических факторов в механизме развития КПЛ слизистой оболочки рта [1]. Ряд исследователей считает, что в основе патогенеза КПЛ СОР лежат антигенспецифические механизмы, не исключаются при этом и неспецифические механизмы.…”

Section: Abstract: Lichen Planus Oral Mucosa Dermatosis Pathogeneunclassified

Features of immune status in patients with various clinical forms of oral lichen planus

Чуйкин

Akmalova

Мирсаяпова

et al. 2019

Russian Journal of Infection and Immunity

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Oral mucosal lesions hold one of the lead places in the structure of dental diseases. Oral lichen planus (OLP) considered as a multifactorial disease is of top priority among dermatoses of oral mucosa and red lip border. Diverse putative concepts behind developing lichen planus pathogenesis are discussed including immunoallergic, viral, genetic and membrane-destructive theories. However, an immune theory is thought to play a crucial role in developing lichen planus. Despite documented induction of immune mechanisms, complex interaction between pathological process and normal defense response as well as stirred interest to it, multiple aspects of immunological conflict in lichen planus remain unclear. Few data describing altered immune parameters depending on clinical picture of lichen planus are currently available that suggested to perform the study aimed at examining immune status in patients with various forms of oral lichen planus. There were enrolled 286 oral lichen planus patients (248 females and 38 males), aged 2784 years. Based on clinical picture, all OLP patients were divided into 6 groups: a typical type, exudative-congestive, erosive-ulcerous, hyperkeratotic, atypical, bullous type. An immune status in peripheral blood samples was evaluated by analyzing innate defense mechanisms as well as humoral and cellular immunity. Multiple altered immune parameters characterized by impaired phagocytic capture and metabolic activity, disimmunoglobulinemia, altered ratio of major immunocompetent cell types and subsets were documented during the study. Moreover, OLP patients with typical, hyperkeratotic, exudative hyperemic, atypical and erosive ulcerous forms were found to have increased amount of CD4+ helper T cells associated with a self-sustained immune response due to suppressed elimination of pathogenic agents consequently resulting in developing autoimmune process. While analyzing immune status in OLP patients, it allowed to find a relationship between dysphagocytosis signs, impaired humoral and cellular immunity as well as various clinical forms of the disease. Thus, it suggests imbalanced mechanisms responsible for pathogen elimination might play a role in OLP pathogenesis, including infectious agents being involved in its development.

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Section: Abstract: Lichen Planus Oral Mucosa Dermatosis Pathogeneunclassified

Features of immune status in patients with various clinical forms of oral lichen planus

Чуйкин

Akmalova

Мирсаяпова

et al. 2019

Russian Journal of Infection and Immunity

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Clinical Manifestations of Oral Mucosal Lesions in Verious Dermatosis

Guryevskaya

Usmanova

Hismatullina

et al. 2020

Actual Problems in Dentistry

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Subject. This review presents a modern literature review on the clinical manifestations of severe autoimmune disease — pemphigus vulgaris, chronic genetic determinate dermatosis — by the example of epidermolysis bullosa, dermatosis — lichen planus, acute immuno-mediated disease — multiforme exudative erythema. The goal is to conduct a systematic analysis of modern domestic and foreign literature to determine some features of the clinical manifestations of chronic dermatoses with lesions of the oral mucosa. Methodology. A review of the studies allows us to consider the etiology and pathogenesis of the development of these nosologies, approaches to modern classification, as well as an analysis of their clinical features with an emphasis on differential diagnosis. Results. It was noted that with combined damage to the skin and oral mucosa, the diagnosis of these dermatoses in patients does not present any particular difficulties. However, the significance of determining pathognomonic signs of damage to the oral mucosa with a particular dermatosis increases significantly with an isolated lesion of the oral mucosa, and when it is the primary and only manifestation of skin disease. Conclusions. Undoubtedly, the principle of continuity of the interested specialties among which are undoubted - dermatovenerologists, dentists, gastroenterologists, gynecologists, neuropsychiatrists, has great prospects in both diagnosis and complex treatment. Nevertheless, for their widespread use, the local and general treatment of these patients needs to be verified, solving urgent problems of introducing and adapting modern technologies for rapid prototyping them into practical healthcare, which together will allow significant progress in their diagnosis and prevention.

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Modern Aspects of the Pathogenesis of Lichen Planus of the Oral Mucosa

Akmalova

Chuykin

Chernyshova

et al. 2021

Actual Problems in Dentistry

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Between the blood and the organs, between the blood and tissues there are special barriers (blood-tissue barriers), which represent the multilevel security system of the organism, aimed at providing general and local homeostasis. The protective function of organs and tissues that are protected by blood-tissue barriers is realized by the changes of the permeability barrier for certain substances and is quantitatively estimated by the permeability coefficient (PC). In-depth studies of the functioning of blood-tissue barriers in lichen planus of the oral mucosa (LP OM) are relevant today. But they have not been conducted yet. In this study were involved 191 patients with various forms of lichen planus of the oral mucosa ( typical — 43 patients, exudative — hyperemic — 43 people, erosive-ulcerative — 47 patients, hyperkeratotic — 24 people, atypical — 28 patients, bullous — 6 people) a violation of a permeability condition of the blood-tissue barriers for some mineral elements (zinc, copper, iron, magnesium), which is of importance in the pathogenesis of the disease was found. This manifests itself in multidirectional changes in mineral composition of blood serum and oral fluid, which correlate to the severity of the clinical course of the disease. Thus, the definition of pathogenetic importance of the detected changes will allow solving the issue of a possible correction of the mineral content, resulting in a deficit, by assigning mineral supplements. The expected effects can be a relief of the clinical course of the process, a more rapid healing of erosions and ulcers in the mouth, improvement of the general condition of patients and improving their quality of life.

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The use of genetic markers in predicting of oral lichen planus development and recurrence

Cited by 6 publications

References 1 publication

Features of immune status in patients with various clinical forms of oral lichen planus

Features of immune status in patients with various clinical forms of oral lichen planus

Clinical Manifestations of Oral Mucosal Lesions in Verious Dermatosis

Modern Aspects of the Pathogenesis of Lichen Planus of the Oral Mucosa

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