The use of (S)-(−)-1-(1-naphthyl)ethylamine as a resolving agent for α-methoxy fatty acids

Chiral reagents for the determination of enantiomeric excess and absolute configuration using NMR spectroscopy

“…For the two enantiomers, caution is needed when interpreting the data and a similar anthryl derivative [1-(10-bromo-1-anthryl)-2naphthoic acid] provided more reliable results. 27 Derivatives with 1-(1-naphthyl)ethylamine can also be used to assign the AC of ␤-substituted carboxylic acids that have substituents other than a methyl group. In these cases, the distribution of ap and sp conformers changes from compound to compound, thereby influencing the degree of distinction.…”

Chiral Reagents for the Determination of Enantiomeric Excess and Absolute Configuration Using NMR Spectroscopy

“…For example, derivatization of ␣-methoxy fatty acids with 1-(1-naphthyl)ethylamine results in a distinction of the methoxy resonances of the diastereo- meric amides that can be used to determine optical purity. 27 Derivatives with 1-(1-naphthyl)ethylamine can also be used to assign the AC of ␤-substituted carboxylic acids that have substituents other than a methyl group. 28 Acids of known configurations with a variety of ␤-substituents were tested to validate the method.…”