The use of scanning contactless conductivity detection for the characterisation of stationary phases in micro-fluidic chips

Walsh, Zarah; Vázquez, Mercedes; Benito‐Lopez, Fernando; Paull, Brett; Macka, Mirek; Švec, František; Diamond, Dermot

doi:10.1039/c003584j

Cited by 12 publications

(4 citation statements)

References 13 publications

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“…C 4 D continues to be used as a diagnostic tool in the characterization of monolithic chromatographic columns for IC and HPLC . The homogeneity of the stationary phase in a microfluidic chromatography chip has also been determined . A recent review article by Connolly et al gives a comprehensive overview of the applications of scanning C 4 D in the characterization of various capillary columns.…”

Section: C4d In Other Flow‐through Methodsmentioning

confidence: 99%

Contactless conductivity detection for analytical techniques: Developments from 2010 to 2012

Kubáň

Hauser

2012

Electrophoresis

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The developments in the field of capacitively coupled contactless conductivity detection in the approximate period from July 2010 to June 2012 are traced. Few reports concerning fundamental studies or new detector designs have appeared. On the other hand, applications in standard CZE are flourishing and contactless conductivity measurements are increasingly being employed as part of novel or more sophisticated experimental systems. Work on the lab-on-chip devices integrating contactless conductivity detection is continuing. A range of reports on the use of the simple yet powerful detection technique of contactless conductivity measurements in chromatographic separation as well as for analytical methods not including a separation step have also appeared.

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Section: C4d In Other Flow‐through Methodsmentioning

confidence: 99%

Contactless conductivity detection for analytical techniques: Developments from 2010 to 2012

Kubáň

Hauser

2012

Electrophoresis

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“…Walsh et al reported the use of scanning C 4 D (sC 4 D) for the evaluation of the structural homogeneity and density of both packed and monolithic stationary phases in microfluidic chips. 84 The chip was placed on top of the substrate containing the copper electrodes and, by sliding the chip through the microchannel, the packed columns were sequentially scanned along their whole length, from the beginning to the end as illustrated in Fig. 7(A).…”

Section: Other Applicationsmentioning

confidence: 99%

Capacitively coupled contactless conductivity detection on microfluidic systems—ten years of development

et al. 2012

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The use of capacitively coupled contactless conductivity detection (C 4 D) on miniaturized systems has increased considerably over the last few years. Since the first report, 10 years ago, several advances on the detection cell geometry, strategies for increasing the sensitivity and a wide range of applications have been reported. This review intends to cover the main features related to the instrumental setup of this detection method for analytical and bioanalytical assays on microfluidic chips.

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“…In the recent years, progresses in micro and nanofabrication techniques enabled a better control of the positioning of microscale electrodes and especially of the thickness of the insulating layer that can be deposited on them. These technical innovations in microelectrode network design and fabrication allowed new insights in contactless application fields such as scanning conductivity, [1], [2] dielectrophoresis actuation, [3], [4], [5], [6] microfluidic pumps, [7], [8] droplets generator, [9] particle sorting [10], [11] and biosensors. [12], [13], [14], [15], [16], [17] Furthermore, an important research topic in the last decade is the development of flexible polymer microdevices for bioanalytical applications integrating electrodes for biodetection.…”

Section: Introductionmentioning

confidence: 99%

Finite element modelling of non-faradic electric impedance spectroscopy through flexible polymer microchip

Kechadi

Chaal

Vivier

et al. 2017

Journal of Electroanalytical Chemistry

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Numerical simulations using finite element method were performed for a better understanding of nonfaradic electric impedance response of microfluidic device with two insulated planar-microband electrodes i.e. electrodes without direct contact with electrolyte flowing in the microchannel. The results showed that calculated electric impedance depends not only on the microchannel geometry and dielectric properties of electrolyte flowing in microchannel, but also on the dielectric response of the insulated PET layer. It was pointed out that a microfluidic device with insulated microelectrodes behaves as a dielectric device, in which a strong capacitive coupling effect takes place in the high-frequency domain. An analytical expression that allows predicting the optimal frequency range to be used for measuring real-time contactless microchannel resistance changes was proposed. This non-faradic impedance spectroscopy appears to be a promising approach for the new generation of sensors and biosensors in miniaturized flexible or patch polymer devices.

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The use of scanning contactless conductivity detection for the characterisation of stationary phases in micro-fluidic chips

Abstract: The use of scanning capacitively coupled contactless conductivity detection for the evaluation of the structural homogeneity and density of both packed and monolithic stationary phases in microfluidic chips is presented here for the first time.

Cited by 12 publications

References 13 publications

Contactless conductivity detection for analytical techniques: Developments from 2010 to 2012

Contactless conductivity detection for analytical techniques: Developments from 2010 to 2012

Capacitively coupled contactless conductivity detection on microfluidic systems—ten years of development

Finite element modelling of non-faradic electric impedance spectroscopy through flexible polymer microchip

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