The use of shear rate–diameter dose–response curves as an alternative to the flow-mediated dilation test

Wu, Brian; Credeur, Daniel P.; Fryer, Simon M; Stoner, Lee

doi:10.1016/j.mehy.2014.12.014

Cited by 6 publications

(3 citation statements)

References 52 publications

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“…According to Stoner et al, there are a few main limitations associated with the standard FMD methodology: first, inappropriate expression of FMD, second, measurement variance associated with a short-lived FMD response, third, most studies fail to account for the FMD stimulus, and lastly, poor reproducibility [ 122 , 123 ].…”

Section: Current Limitations Of Fmd Procedures and Future Trendsmentioning

confidence: 99%

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Endothelial Function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the Evaluation of the Cardiovascular System

Mućka

Miodońska

Jakubiak

et al. 2022

IJERPH

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Cardiovascular diseases (CVDs) in the course of atherosclerosis are one of the most critical public health problems in the world. Endothelial cells synthesize numerous biologically active substances involved in regulating the functions of the cardiovascular system. Endothelial dysfunction is an essential element in the pathogenesis of atherosclerosis. Thus, the assessment of endothelial function in people without overt CVD allows for a more accurate estimate of the risk of developing CVD and cardiovascular events. The assessment of endothelial function is primarily used in scientific research, and to a lesser extent in clinical practice. Among the tools for assessing endothelial function, we can distinguish biochemical and physical methods, while physical methods can be divided into invasive and non-invasive methods. Flow-mediated dilation (FMD) is based on the ultrasound assessment of changes in the diameter of the brachial artery as a result of increased blood flow. FMD is a non-invasive, safe, and repeatable test, but it must be performed by qualified and experienced medical staff. The purpose of this paper is to present the literature review results on the assessment of endothelial function using the FMD method, including its methodology, applications in clinical practice and research, limitations, and future perspectives.

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Section: Current Limitations Of Fmd Procedures and Future Trendsmentioning

confidence: 99%

“…It has been shown that shear rate-diameter dose–response curves could improve the traditional FMD measurement and serve as a superior clinical and research tool for assessing cardiovascular disease risk in various populations [ 123 ].…”

Section: Current Limitations Of Fmd Procedures and Future Trendsmentioning

confidence: 99%

Endothelial Function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the Evaluation of the Cardiovascular System

Mućka

Miodońska

Jakubiak

et al. 2022

IJERPH

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“…Modeling of the shear-dilatory, dose-response ( 23) or exposure-response (24) relationship has been previously suggested as an alternative means to evaluate FMD; however, these prior models would require clinically prohibitive changes in how FMD is measured (23) and face parameter identifiability issues (24). In the present study, we developed an exposure-response modeling approach to derive parameters from the FMD test that describe both the shear exposure and diameter response.…”

mentioning

confidence: 99%

Exposure-response modeling of flow-mediated dilation provides an unbiased and informative measure of endothelial function

Brackle

Harris

Hallow

2017

Journal of Applied Physiology

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The brachial artery flow-mediated dilation (FMD) test is the most widely utilized method to evaluate endothelial function noninvasively in humans by calculating the percent change in diameter (FMD%). However, the underutilized velocity and diameter time course data, coupled with confounding influences in shear exposure, noise, and upward bias, make the FMD test less desirable. In this study, we developed an exposure-response, model-based approach that not only quantifies FMD based on the rich velocity and diameter data, it overcomes previously acknowledged challenges. FMD data were obtained from 15 apparently healthy participants, each exposed to four different cuff occlusion durations. The velocity response following cuff release was described by an exponential model with two parameters defining peak velocity and rate of decay. Shear exposure derived from velocity was used to drive the diameter response model, which consists of additive constriction and dilation terms. Three parameters describing distinct aspects of the vascular response to shear (magnitude of the initial constriction response, and magnitude and time constant of the dilation response) were estimated for both the individuals and population. These parameters are independent of shear exposure. Thus this approach produces identifiable and physiologically meaningful parameters that may provide additional information for comparing differences between experimental groups or over time, and provides a means to completely account for shear exposure. While flow-mediated dilation (FMD) is a valuable tool for evaluating endothelial function, analytical challenges include confounding influences of shear exposure, upward bias, and underutilization of rich time course data collected during FMD testing. We have developed an exposure-response, model-based approach that quantifies endothelial function based on the velocity and diameter data and fully accounts for shear exposure. It produces physiologically meaningful parameters that may provide useful information for comparing differences between experimental groups or over time.

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Influence of aerobic fitness on vasoreactivity in young men

et al. 2017

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The use of shear rate–diameter dose–response curves as an alternative to the flow-mediated dilation test

Abstract: Lee (2015) The use of shear rate-diameter dose-response curves as an alternative to the flow-mediated dilation test. Medical Hypotheses, 84 (2). pp. 85-90. ISSN 0306-9877 Official URL: http://dx.

Cited by 6 publications

References 52 publications

Endothelial Function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the Evaluation of the Cardiovascular System

Endothelial Function Assessment by Flow-Mediated Dilation Method: A Valuable Tool in the Evaluation of the Cardiovascular System

Exposure-response modeling of flow-mediated dilation provides an unbiased and informative measure of endothelial function

Influence of aerobic fitness on vasoreactivity in young men

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