The Use of Type I and Type III Injectable Human Collagen for Dermal Fill: 10 Years of Clinical Experience in China

Liu, Bingci; Xu, Zhen-Peng; Yu, Ruirao; Wang, Jiabi; Wang, Zengfang; Harrell, Carl Randall

doi:10.1055/s-2005-919719

Cited by 7 publications

(4 citation statements)

References 13 publications

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“…However, there is a very high interspecies homology of collagens so that the results can be transferred very well [ 58 ]. In addition, no adverse or immune reactions have been reported in human clinical trials with injected collagen I and III [ 59 ]. Only an unspecific background reaction with rather low MFI-values without significant immunization patterns were found in both untreated and treated animals, when the sera of the rats were tested for anti-human HLA antibodies.…”

Section: Discussionmentioning

confidence: 99%

First Human Leucocyte Antigen (HLA) Response and Safety Evaluation of Fibrous Demineralized Bone Matrix in a Critical Size Femoral Defect Model of the Sprague-Dawley Rat

et al. 2020

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Treatment of large bone defects is one of the great challenges in contemporary orthopedic and traumatic surgery. Grafts are necessary to support bone healing. A well-established allograft is demineralized bone matrix (DBM) prepared from donated human bone tissue. In this study, a fibrous demineralized bone matrix (f-DBM) with a high surface-to-volume ratio has been analyzed for toxicity and immunogenicity. f-DBM was transplanted to a 5-mm, plate-stabilized, femoral critical-size-bone-defect in Sprague-Dawley (SD)-rats. Healthy animals were used as controls. After two months histology, hematological analyses, immunogenicity as well as serum biochemistry were performed. Evaluation of free radical release and hematological and biochemical analyses showed no significant differences between the control group and recipients of f-DBM. Histologically, there was no evidence of damage to liver and kidney and good bone healing was observed in the f-DBM group. Reactivity against human HLA class I and class II antigens was detected with mostly low fluorescence values both in the serum of untreated and treated animals, reflecting rather a background reaction. Taken together, these results provide evidence for no systemic toxicity and the first proof of no basic immunogenic reaction to bone allograft and no sensitization of the recipient.

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Section: Discussionmentioning

confidence: 99%

First Human Leucocyte Antigen (HLA) Response and Safety Evaluation of Fibrous Demineralized Bone Matrix in a Critical Size Femoral Defect Model of the Sprague-Dawley Rat

et al. 2020

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“…These allergic reactions are believed to be an immunological response to bovine collagen. 39 Additionally, the Centers for Disease Control and Prevention and the FDA both concluded that a significant statistical association exists between bovine collagen used in dermal fillers and dermatomyositis. 40 Autologous and cadaveric human collagens have a lower risk of hypersensitivity, but possess the risk of disease transmission.…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Human Collagen Scaffolds for Skin Tissue Engineering

Willard

Drexler²,

Das³

et al. 2013

Tissue Engineering Part A

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Tissue engineering scaffolds are commonly formed using proteins extracted from animal tissues, such as bovine hide. Risks associated with the use of these materials include hypersensitivity and pathogenic contamination. Human-derived proteins lower the risk of hypersensitivity, but possess the risk of disease transmission. Methods engineering recombinant human proteins using plant material provide an alternate source of these materials without the risk of disease transmission or concerns regarding variability. To investigate the utility of plant-derived human collagen (PDHC) in the development of engineered skin (ES), PDHC and bovine hide collagen were formed into tissue engineering scaffolds using electrospinning or freeze-drying. Both raw materials were easily formed into two common scaffold types, electrospun nonwoven scaffolds and lyophilized sponges, with similar architectures. The processing time, however, was significantly lower with PDHC. PDHC scaffolds supported primary human cell attachment and proliferation at an equivalent or higher level than the bovine material. Interleukin-1 beta production was significantly lower when activated THP-1 macrophages where exposed to PDHC electrospun scaffolds compared to bovine collagen. Both materials promoted proper maturation and differentiation of ES. These data suggest that PDHC may provide a novel source of raw material for tissue engineering with low risk of allergic response or disease transmission.

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“…Immediate correction of dermal defects and stimulation of new tissue generation by slowly degradable soft tissue fillers is ideal for dermal fillers. 37 In this study, DiHMs (pH 5 and 7) induced a gradual increase in collagen deposition and neovascularization. The thickness of fibroconnective tissue, the degree of neovascularization and infiltration of macrophages, and giant cells, increased gradually with time in the DiHM implants.…”

Section: Discussionmentioning

confidence: 52%

“…Immediate correction of dermal defects and stimulation of new tissue generation by slowly degradable soft tissue fillers is ideal for dermal fillers . In this study, DiHMs (pH 5 and 7) induced a gradual increase in collagen deposition and neovascularization.…”

Section: Discussionmentioning

confidence: 99%

Effects of crosslinked dextran in hydroxylpropyl methylcellulose on soft tissue augmentation in rats

et al. 2013

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This study compared crosslinked dextrans in hydroxylpropyl methycellulose (DiHMs, pH 5 or 7) with polymethylmethacrylate in bovine collagen (PMMA) and hyaluronic acid (HA) fillers on soft tissue augmentation and safety in rats. HA tended to maintain its size throughout the experimental period but was moveable and friable because of a lack of thick fibroconnective tissue formation. Although, PMMA induced moderately thick fibroconnective tissue formation, its size was decreased markedly from 3-week postimplantation (PI) and became the smallest at 24-month PI. DiHM (pH 7) elicited strong fibrous encapsulation around the filler. Its size decreased slowly but was still considerably maintained at 24-month PI. In contrast, the rate of the DiHM (pH 5) size decrease was slower than that of PMMA, faster DiHM (pH 7), but comparable to HA. Immunohistochemically, types I and III collagens were deposited inside and outside DiHMs (pH 5 and 7). DiHMs (pH 5 and 7), PMMA, and HA showed no adverse reactions. These results suggest that DiHM (pH 7) assures efficacy and safety and is a good candidate for soft tissue augmentation in both humans and animals.

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The Use of Type I and Type III Injectable Human Collagen for Dermal Fill: 10 Years of Clinical Experience in China

Cited by 7 publications

References 13 publications

First Human Leucocyte Antigen (HLA) Response and Safety Evaluation of Fibrous Demineralized Bone Matrix in a Critical Size Femoral Defect Model of the Sprague-Dawley Rat

First Human Leucocyte Antigen (HLA) Response and Safety Evaluation of Fibrous Demineralized Bone Matrix in a Critical Size Femoral Defect Model of the Sprague-Dawley Rat

Plant-Derived Human Collagen Scaffolds for Skin Tissue Engineering

Effects of crosslinked dextran in hydroxylpropyl methylcellulose on soft tissue augmentation in rats

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