The Uterus Smooth Muscular Tissue in Early Puerperium: Involution Mechanisms

Abstract

We have studied transformation of smooth muscular tissue (SMT) of the uterus wall of rats after delivery and used the light and electronic microscopy and the immunohistochemical method. The study of different parts of the uterus in the process of involution has shown different levels of SMT structure functional reorganization. It can be explained by different speed of the involutive processes and peculiarities of the loading functions. The complete involution of the myometrium of the rats’ horns was reached in 7 days after delivery. The same process in the cervix took more time, and correlated increased small cells population. We found that disappearance of large cells became the main factor of SMT reconstruction in all the parts of the uterus during the period after the delivery, the large cells were characterized by a low level of adaptation to the changing factors. The mechanism of the cells disappearance and reconstruction of the population structure depended on apoptosis and proliferation of smooth muscular cells.

Послеродовая Инволюция Миометрия Мышей В Условиях Острого Токсического Гепатоза

“…Основными механизмами, реализующие процессы послеродовой инволюции миометрия, являются клазмацитоз, апоптоз, аутофагия и некроз, причем ведущая роль, по данным некоторых авторов, отдается апоптозу [1,7,12], а в других исследованиях -клазмацитозу [4,10,11]. Исходя из полученных нами данных, преобладающим механизмом инволюции миометрия явился клазмацитоз, поскольку доля ИЦК по сравнению с апоптотически измененными миоцитами была большей.…”